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Immune regulation

Epithelial barrier sites such as the skin, respiratory and gastrointestinal tract, form a physical interface between our bodies and external environments. In addition to creating a physical impediment to pathogens, epithelial barriers include a diverse mix of immune cells, forming a first line of defence against invading pathogens.

Our laboratory studies the role that cells of the immune system play at the initiation, modulation and resolution of immune responses at epithelial barrier sites as well as the homeostatic control of epithelial cells. These studies provide insights into the mechanisms that control the maintenance, activation and function of immune cells located or enriched at mucosal surfaces such as the intestine, ultimately contributing to the prevention of undesirable immune responses that may result in chronic infections, allergies, autoimmunity and an increased risk of cancer.

   

Research Team

Cristina Ferreira
Senior Postdoctoral Researcher
cristina.ferreira@medicina.ulisboa.pt

Germano Teixeira Vicente
MSc Student
germano.vicente@medicina.ulisboa.pt

Gonçalo André Barata Malpica
PhD Student
goncalo.malpica@medicina.ulisboa.pt

Himadri Mukhopadhyay
Postdoctoral Researcher
himadri.mukhopadhyay@medicina.ulisboa.pt

Jean-Christophe Lone
PhD Student
jchris.lone@medicina.ulisboa.pt

João Fernandes
Postdoctoral Researcher
joao.fernandes@medicina.ulisboa.pt

Margarida Kirkby
MSc Student
margarida.kirkby@medicina.ulisboa.pt

Research Areas

  • Epithelial – immune cell interactions
  • Tissue homeostasis
  • Thelper cell differentiation
  • Environmental influences on immunity
  • Mucosal Immunology

Ongoing Research Projects

2020/2021 HighSenseCoV2 Highly sensitive immunoassay for SARS-CoV2 detection using new amplification technology. Coordinator: Marc Veldhoen. Funding Agency: Programa Operacional Regional de Lisboa, PORTUGAL 2020, Fundo Europeu de Desenvolvimento Regional.

2019/2022 Enhancing Tissue Resident Immunity. Coordinator: Marc Veldhoen. Funding Agency: Fundación Bancaria "la Caixa".

2018/2021 Regulação da rede de resposta imunológica epitelial. Coordinator: Marc Veldhoen. Funding Agency: Fundação para a Ciência e a Tecnologia.

2015/2020 EXCELLtoINNOV: Leverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (iMM) trough translational biomedical research in Immunity and Infection. Coordinator: Marc Veldhoen. Funding Agency: European Commission.

Awards

2011 EMBO Young Investigator programme

2010 ERC starting grant

Selected Publications

Leandro Barros, Daryna Piontkivska, Patrícia Figueiredo-Campos, Júlia Fanczal, Sofia Pereira Ribeiro, Marta Baptista, Silvia Ariotti, Nuno Santos, Maria João Amorim, Cristina Silva Pereira, Marc Veldhoen, Cristina Ferreira (2023). CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types. Nature Communications. doi.org/10.1038/s41467-023-41364-w

Zahra Hasan, Kiran Iqbal Masood, Shama Qaiser, Erum Khan, Areeba Hussain, Zara Ghous, Unab Khan, Maliha Yameen, Imran Hassan, Muhammad Imran Nasir, Muhammad Farrukh Qazi, Haris Ali Memon, Shiza Ali, Sadaf Baloch, Zulfiqar A Bhutta, Marc Veldhoen, J Pedro Simas, Syed Faisal Mahmood, Kulsoom Ghias, Rabia Hussain (2023). Investigating the impact of prior COVID-19 on IgG antibody and interferon γ responses after BBIBP-CorV vaccination in a disease endemic population: A prospective observational study. Health Science Reports. doi.org/10.1002/hsr2.1521

Maria Rebelo, Cong Tang, Ana R Coelho, Carlos Labão-Almeida, Matthias M Schneider, Laurie Tatalick, Pedro Ruivo, Marta Pires de Miranda, Andreia Gomes, Tânia Carvalho, Matthew J Walker, Hannes Ausserwoeger, J Pedro Simas, Marc Veldhoen, Tuomas PJ Knowles, Daniel-Adriano Silva, David Shoultz, Gonçalo JL Bernardes (2023). De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection. The Journal of Infectious Diseases. doi.org/10.1093/infdis/jiad135

Marc Veldhoen, Antonio Bertoletti (2023). SARS-CoV-2 clearance after breakthrough infection correlates with fit and happy T cells. Immunology and Cell Biology. doi.org/10.1111/imcb.12654

Muhammad Hasan, Bushra Moiz, Shama Qaiser, Kiran Iqbal Masood, Zara Ghous, Areeba Hussain, Natasha Ali, J Pedro Simas, Marc Veldhoen, Paula Alves, Syed Hani Abidi, Kulsoom Ghias, Erum Khan, Zahra Hasan (2022). IgG antibodies to SARS-CoV-2 in asymptomatic blood donors at two time points in Karachi. PloS One. doi.org/10.1371/journal.pone.0271259

Špela Konjar, Cristina Ferreira, Filipa Sofia Carvalho, Patrícia Figueiredo-Campos, Júlia Fanczal, Sofia Ribeiro, Vanessa Alexandra Morais, Marc Veldhoen (2022). Intestinal tissue-resident T cell activation depends on metabolite availability. Proceedings of the National Academy of Sciences. doi.org/10.1073/pnas.2202144119

Debanjan Mukherjee, Ângelo Ferreira Chora, Jean-Christophe Lone, Ricardo S Ramiro, Birte Blankenhaus, Karine Serre, Mário Ramirez, Isabel Gordo, Marc Veldhoen, Patrick Varga-Weisz, Maria M Mota (2022). Host lung microbiota promotes malaria-associated acute respiratory distress syndrome. Nature Communications. doi.org/10.1038/s41467-022-31301-8

Ana Rita Cruz-Machado, Sofia C Barreira, Matilde Bandeira, Marc Veldhoen, Andreia Gomes, Marta Serrano, Catarina Duarte, Maria Rato, Bruno Miguel Fernandes, Salomé Garcia, Filipe Pinheiro, Miguel Bernardes, Nathalie Madeira, Claúdia Miguel, Rita Torres, Ana Bento Silva, Jorge Pestana, Diogo Almeida, Carolina Mazeda, Filipe Cunha Santos, Patrícia Pinto, Marlene Sousa, Hugo Parente, Graça Sequeira, Maria José Santos, João Eurico Fonseca, Vasco C Romão (2022). Risk Factors for Infection, Predictors of Severe Disease, and Antibody Response to COVID-19 in Patients With Inflammatory Rheumatic Diseases in Portugal—A Multicenter, Nationwide Study. Frontiers in Medicine. doi.org/10.3389/fmed.2022.901817

Špela Konjar, Xenia Ficht, Matteo Iannacone, Marc Veldhoen (2022). Heterogeneity of tissue resident memory T cells. Immunology Letters. doi.org/10.1016/j.imlet.2022.02.009

Leandro Barros, Cristina Ferreira, Marc Veldhoen (2022). The fellowship of regulatory and tissue-resident memory cells. Mucosal Immunology. doi.org/10.1038/s41385-021-00456-w

Syed Hani Abidi, Kehkashan Imtiaz, Akbar Kanji, Shama Qaiser, Erum Khan, Kiran Iqbal, Marc Veldhoen, Kulsoom Ghias, J Pedro Simas, Zahra Hasan (2021). A rapid real-time polymerase chain reaction-based live virus microneutralization assay for detection of neutralizing antibodies against SARS-CoV-2 in blood/serum. PloS One. doi.org/10.1371/journal.pone.0259551

Luísa Canto e Castro, Andreia Gomes, Marta Serrano, Ana Helena Guia Pereira, Rita Ribeiro, Patrícia Napoleão, Inês Domingues, Cláudia Silva, Júlia Fanczal, Ângela Afonso, Andreia Lopes, Ionela Toader, Maria José Rego de Sousa, José Germano Rego de Sousa, Germano de Sousa, Maria M Mota, Bruno Silva‐Santos, Marc Veldhoen, Ruy M Ribeiro (2021). Longitudinal SARS‐CoV‐2 seroprevalence in Portugal and antibody maintenance 12 months after infection. European Journal of Immunology. doi.org/10.1002/eji.202149619

Miguel Esperança-Martins, Lisa Gonçalves, Inês Soares-Pinho, Andreia Gomes, Marta Serrano, Birte Blankenhaus, Patrícia Figueiredo-Campos, Ana Catarina-Marques, Ana Castro-Barbosa, Ana Cardoso, Pedro Antunes-Meireles, Henrique Atalaia-Barbacena, Pedro Gaspar, Patrícia Howell-Monteiro, António Pais-de-Lacerda, Catarina Mota, Marc Veldhoen (2021). Humoral Immune Response of SARS-CoV-2–Infected Patients with Cancer: Influencing Factors and Mechanisms. The Oncologist. doi.org/10.1002/onco.13828

Cristina C Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela Skobe, Marc Veldhoen, Simone Moretti, Silvia Formenti, Sandra Demaria, Rajesh K Soni, Roberta Galarini, Roccaldo Sardella, Gregoire Lauvau, Chaim Putterman, Kari Alitalo, Ursula Grohmann, Laura Santambrogio (2021). 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine. Nature Communications. doi.org/10.1038/s41467-021-24785-3

Amelia C Trombetta, Guilherme B Farias, André MC Gomes, Ana Godinho-Santos, Pedro Rosmaninho, Carolina M Conceicao, Joel Laia, Diana F Santos, Afonso RM Almeida, Catarina Mota, Andreia Gomes, Marta Serrano, Marc Veldhoen, Ana E Sousa, Susana M Fernandes (2021). Severe COVID-19 recovery is associated with timely acquisition of a myeloid cell immune-regulatory phenotype. Frontiers in Immunology. doi.org/10.3389/fimmu.2021.691725

João Viana, Christiaan H van Dorp, Ana Nunes, Manuel C Gomes, Michiel van Boven, Mirjam E Kretzschmar, Marc Veldhoen, Ganna Rozhnova (2021). Controlling the pandemic during the SARS-CoV-2 vaccination rollout. Nature Communications. doi.org/10.1038/s41467-021-23938-8

Marc Veldhoen, Vanessa Zuzarte‐Luis (2021). Academic labs supporting COVID‐19 diagnostics. European Journal of Immunology. doi: 10.1002/eji.202170015

Marc Veldhoen, J Pedro Simas (2021). Endemic SARS-CoV-2 will maintain post-pandemic immunity. Nature Reviews Immunology. doi.org/10.1038/s41577-020-00493-9

Veloso, Vera Vicente, Dalila Alves, Inês Domingues, Cláudia Silva, Andreia Gomes, Marta Serrano, Ângela Afonso, Marc Veldhoen, Maria José Rego de Sousa, José Germano Rego de Sousa, Germano de Sousa, Maria M Mota, Bruno Silva-Santos, Ruy M Ribeiro (2021). Prevalence of SARS-CoV-2 Antibodies after First 6 Months of COVID-19 Pandemic, Portugal. Emerging Infectious Diseases. doi:10.3201/eid2711.210636

Špela Konjar, Miha Pavšič, Marc Veldhoen (2021). Regulation of Oxygen Homeostasis at the Intestinal Epithelial Barrier Site. International Journal of Molecular Sciences. doi.org/10.3390/ijms22179170

Eliseu Frank de Araújo, Nycolas Willian Preite, Marc Veldhoen, Flávio Vieira Loures, Vera Lúcia Garcia Calich (2020). Pulmonary paracoccidioidomycosis in AhR deficient hosts is severe and associated with defective Treg and Th22 responses. Scientific Reports. doi.org/10.1038/s41598-020-68322-6

Juri Kazakevych, Jérémy Denizot, Anke Liebert, Mariana Portovedo, Mia Mosavie, Payal Jain, Claudia Stellato, Claire Fraser, Renan Oliveira Corrêa, Marina Célestine, Raphaël Mattiuz, Hanneke Okkenhaug, J Ross Miller, Marco Aurélio Ramirez Vinolo, Marc Veldhoen, Patrick Varga-Weisz (2020). Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium. Genome Biology. doi.org/10.1186/s13059-020-01976-7

Patrícia Figueiredo‐Campos, Birte Blankenhaus, Catarina Mota, Andreia Gomes, Marta Serrano, Silvia Ariotti, Catarina Costa, Helena Nunes‐Cabaço, António M Mendes, Pedro Gaspar, M Conceição Pereira‐Santos, Fabiana Rodrigues, Jorge Condeço, M Antonia Escoval, Matilde Santos, Mario Ramirez, José Melo‐Cristino, J Pedro Simas, Eugenia Vasconcelos, Ângela Afonso, Marc Veldhoen (2020). Seroprevalence of anti‐SARS‐CoV‐2 antibodies in COVID‐19 patients and healthy volunteers up to 6 months post disease onset. European Journal of Immunology. doi.org/10.1002/eji.202048970

Stark AK, Davenport ECM, Patton DT, Scudamore CL, Vanhaesebroeck B, Veldhoen M, Garden OA, Okkenhaug K (2020). Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation. Journal of Immunology. doi: 10.4049/jimmunol.2000043.

Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar Š, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M (2020). Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells. Nature Immunology. doi: 10.1038/s41590-020-0674-9.

Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P, Stellato C, Fraser C, Corrêa RO, Célestine M, Mattiuz R, Okkenhaug H, Miller JR, Vinolo MAR, Veldhoen M, Varga-Weisz P (2020). Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium. Genome Biology. doi: 10.1186/s13059-020-01976-7.

Cossarizza A, Chang HD, Radbruch A, Acs A, Adam A, Adam‐Klages S, Agace W et al. (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology. doi: 10.1002/eji.201970107.

Ariotti S, Veldhoen M (2019). Immunology: Skin T Cells Switch Identity to Protect and Heal. Current Biology. doi: 10.1016/j.cub.2019.01.055.

Singh Y, Zhang S, Al-Maghout T, Cao I, Pelzl L, Salker M, Veldhoen M, Cheng A, Lang F (2019). Gut bacterial metabolite Urolithin A (UA) mitigates Ca2+ entry in T cells by regulating miR-10a-5p. Frontiers in Immunology. doi: 10.3389/fimmu.2019.01737.

Konjar S, Veldhoen M (2019). Dynamic metabolic state of tissue resident CD8 T cells. Frontiers in Immunology. doi: 10.3389/fimmu.2019.01683

Figueiredo-Campos P, Ferreira C, Blankenhaus B, Veldhoen M (2018). Eimeria vermiformis Infection Model of Murine Small Intestine. Bio-Protocols. 10.21769/BioProtoc.3122.

Veldhoen M, Blankenhaus B, Konjar Š, Ferreira C (2018). Metabolic wiring of murine T cell and intraepithelial lymphocyte maintenance and activation. European Journal of Immunology. doi: 10.1002/eji.201646745.

Konjar Š, Frising UC, Ferreira C, Hinterleitner R, Mayassi T, Zhang Q, Blankenhaus B, Haberman N, Loo Y, Guedes J, Baptista M, Innocentin S, Stange J, Strathdee D, Jabri B, Veldhoen M (2018). Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes. Science Immunology. doi: 10.1126/sciimmunol.aan2543.

Fellows R, Denizot J, Stellato C, Cuomo A, Jain P, Stoyanova E, Balázsi S, Hajnády Z, Liebert A, Kazakevych J, Blackburn H, Corrêa RO, Fachi JL, Sato FT, Ribeiro WR, Ferreira CM, Perée H, Spagnuolo M, Mattiuz R, Matolcsi C, Guedes J, Clark J, Veldhoen M, Bonaldi T, Vinolo MAR, Varga-Weisz P (2018). Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases. Nature Communications. doi: 10.1038/s41467-017-02651-5.

Š. Konjar, B. Blankenhaus, M. Veldhoen (2018). Oxygen starvation during T cell priming boosts cancer-killing potential. Translational Cancer Research.

Brucklacher-Waldert V, Ferreira C, Stebegg M, Fesneau O, Innocentin S, Marie JC, Veldhoen M (2017). Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation. Cell Rep.

Veldhoen M (2017). Interleukin 17 is a chief orchestrator of immunity. Nature Immunology.

Stubbs TM, Bonder MJ, Stark AK, Krueger F; BI Ageing Clock Team, von Meyenn F, Stegle O, Reik W (2017). Multi-tissue DNA methylation age predictor in mouse. Genome Biology.

Goverse G, Molenaar R, Macia L, Tan J, Erkelens MN, Konijn T, Knippenberg M, Cook EC, Hanekamp D, Veldhoen M, Hartog A, Roeselers G, Mackay CR, Mebius RE (2017). Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells. The Journal Immunology.

Veldhoen M (2017). Th17 Cells Require You to Chew before You Swallow. Immunity.

Konjar Š, Ferreira C, Blankenhaus B, Veldhoen M (2017). Intestinal Barrier Interactions with Specialized CD8 T Cells. Frontiers in Immunology.

Cossarizza, A., Chang, H.-D., Radbruch, A., Andrä, I., Annunziato, F., Bacher, P., Barnaba, V., Battistini, L., Bauer, W. M., Baumgart, S., Becher, B., Beisker, W., Berek, C., Blanco, A., Borsellino, G., Boulais, P. E., Brinkman, R. R., Büscher, M., Busch, D. H., Bushnell, T. P., Cao, X., Cavani, A., Chattopadhyay, P. K., Cheng, Q., Chow, S., Clerici, M., Cooke, A., Cosma, A., Cosmi, L., Cumano, A., Dang, V. D., Davies, D., De Biasi, S., Del Zotto, G., Della Bella, S., Dellabona, P., Deniz, G., Dessing, M., Diefenbach, A., Di Santo, J., Dieli, F., Dolf, A., Donnenberg, V. S., Dörner, T., Ehrhardt, G. R. A., Endl, E., Engel, P., Engelhardt, B., Esser, C., Everts, B., Falk, C. S., Fehniger, T. A., Filby, A., Fillatreau, S., Follo, M., Förster, I., Foster, J., Foulds, G. A., Frenette, P. S., Galbraith, D., Garbi, N., García-Godoy, M. D., Ghoreschi, K., Gibellini, L., Goettlinger, C., Goodyear, C. S., Gori, A., Grogan, J., Gross, M., Grützkau, A., Grummitt, D., Hahn, J., Hammer, Q., Hauser, A. E., Haviland, D. L., Hedley, D., Herrera, G., Herrmann, M., Hiepe, F., Holland, T., Hombrink, P., Houston, J. P., Hoyer, B. F., Huang, B., Hunter, C. A., Iannone, A., Jäck, H.-M., Jávega, B., Jonjic, S., Juelke, K., Jung, S., Kaiser, T., Kalina, T., Keller, B., Khan, S., Kienhöfer, D., Kroneis, T., Kunkel, D., Kurts, C., Kvistborg, P., Lannigan, J., Lantz, O., Larbi, A., LeibundGut-Landmann, S., Leipold, M. D., Levings, M. K., Litwin, V., Liu, Y., Lohoff, M., Lombardi, G., Lopez, L., Lovett-Racke, A., Lubberts, E., Ludewig, B., Lugli, E., Maecker, H. T., Martrus, G., Matarese, G., Maueröder, C., McGrath, M., McInnes, I., Mei, H. E., Melchers, F., Melzer, S., Mielenz, D., Mills, K., Mjösberg, J., Moore, J., Moran, B., Moretta, A., Moretta, L., Mosmann, T. R., Müller, S., Müller, W., Münz, C., Multhoff, G., Munoz, L. E., Murphy, K. M., Nakayama, T., Nasi, M., Neudörfl, C., Nolan, J., Nourshargh, S., O'Connor, J.-E., Ouyang, W., Oxenius, A., Palankar, R., Panse, I., Peterson, P., Peth, C., Petriz, J., Philips, D., Pickl, W., Piconese, S., Pinti, M., Pockley, A. G., Podolska, M. J., Pucillo, C., Quataert, S. A., Radstake, T. R. D. J., Rajwa, B., Rebhahn, J. A., Recktenwald, D., Remmerswaal, E. B.M., Rezvani, K., Rico, L. G., Robinson, J. P., Romagnani, C., Rubartelli, A., Ruland, J., Sakaguchi, S., Sala-de-Oyanguren, F., Samstag, Y., Sanderson, S., Sawitzki, B., Scheffold, A., Schiemann, M., Schildberg, F., Schimisky, E., Schmid, S. A., Schmitt, S., Schober, K., Schüler, T., Schulz, A. R., Schumacher, T., Scotta, C., Shankey, T. V., Shemer, A., Simon, A.-K., Spidlen, J., Stall, A. M., Stark, R., Stehle, C., Stein, M., Steinmetz, T., Stockinger, H., Takahama, Y., Tarnok, A., Tian, Z., Toldi, G., Tornack, J., Traggiai, E., Trotter, J., Ulrich, H., van der Braber, M., van Lier, R. A. W., Veldhoen, M., Vento-Asturias, S., Vieira, P., Voehringer, D., Volk, H.-D., von Volkmann, K., Waisman, A., Walker, R., Ward, M. D., Warnatz, K., Warth, S., Watson, J. V., Watzl, C., Wegener, L., Wiedemann, A., Wienands, J., Willimsky, G., Wing, J., Wurst, P., Yu, L., Yue, A., Zhang, Q., Zhao, Y., Ziegler, S. and Zimmermann, J. (2017), Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology.

Brucklacher-Waldert, V., Ferreira, C., Innocentin, S., Kamdar, S., Withers, D.R., Kullberg, C.M., and Veldhoen, M. (2016). Tbet or continued RORγt expression are not required for Th17-associated immunopathology. Journal of Immunology.

Barros-Martins, J., Schmolka, N., Fontinha, D., Pires de Miranda, M., Simas, J.P., Brok, I., Ferreira, C., Veldhoen, M., Silva-Santos, B., and Serre, K. (2016). Effector gammadelta T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors. Journal of Immunology.

Withers, D.R., Hepworth, M.R., Wang, X., Mackley, E.C., Halford, E.E., Dutton, E.E., Marriott, C.L., Brucklacher-Waldert, V., Veldhoen, M., Kelsen, J., et al. (2016). Transient inhibition of ROR-gammat therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nature Medicine 22, 319-323.

Bénézech, C., N-T. Luu, J.A. Walker, A.A Kruglov, Y. Loo, K. Nakamura, Y. Zhang, S. Nayar, L.H. Jones, A. Flores-Lanarica, A. McIntosh, J. Marshall, F. Barone, G. Besra, K. Miles, J.E. Allen, M. Gray, G. Kollias, A.F. Cunningham, D. Withers, K.M. Toellner, N.D. Jones, M. Veldhoen, S.A. Nedospasov, A.N.J. McKenzie and J.H. Caamaño. (2015) Inflammation-Induced Formation of Fat-Associated Lymphoid Clusters. Nature Immunology 16, 819-828.

Puccetti, P. , F. Fallarino, A. Italiano, I. Soubeyran, G. MacGrogan, M. Debled, V. Velasco, D. Bodet, S. Eimer, M. Veldhoen, G.C. Prendergast, M. Platten, A. Bessede and G. Guillemin. (2015) Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers. PLoS One 10, e0122046.

Stranks, A. J., A. L. Hansen, I. Panse, M. Mortensen, D. J. Ferguson, D. J. Puleston, K. Shenderov, A. S. Watson, M. Veldhoen, K. Phadwal, V. Cerundolo and A. K. Simon. (2015) Autophagy Controls Acquisition of Aging Features in Macrophages. Journal of Innate Immunology 7, no. 4 (2015): 375-391.

Linterman, M.A., Denton, A.E., Divekar, D.P., Zvetkova, I., Kane, L., Ferreira, C., Veldhoen, M., Clare, S., Dougan, G., Espeli, M., et al. (2014). CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. eLife 3.

Marriott, C.L., Mackley, E.C., Ferreira, C., Veldhoen, M., Yagita, H., and Withers, D.R. (2014). OX40 controls effector CD4(+) T-cell expansion, not follicular T helper cell generation in acute Listeria infection. European Journal of Immunology 44, 2437-2447.

Zaid, A., Mackay, L.K., Rahimpour, A., Braun, A., Veldhoen, M., Carbone, F.R., Manton, J.H., Heath, W.R., and Mueller, S.N. (2014). Persistence of skin-resident memory T cells within an epidermal niche. Proceedings of the National Academy of Sciences of the United States of America 111, 5307-5312.

Sriskantharajah, S., Guckel, E., Tsakiri, N., Kierdorf, K., Brender, C., Ben-Addi, A., Veldhoen, M., Tsichlis, P.N., Stockinger, B., O'Garra, A., et al. (2014). Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase. Journal of Immunology 192, 3518-3529.

Mastelic, B., Freitas do Rosario, A.P., Veldhoen, M., Renauld, J.-C., Jarra, W., Sponaas, A.-M., Roetynck, S., Stockinger, B., and Langhorne, J. (2012). IL-22 protects against liver pathology and lethality of an experimental blood-stage malaria infection. Frontiers in Immunology 3.

Li, Y., Innocentin, S., Withers, D.R., Roberts, N.A., Gallagher, A.R., Grigorieva, E.F., Wilhelm, C., and Veldhoen, M. (2011). Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation. Cell 147, 629-640.

Hirota, K., Duarte, J.H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D.J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011). Fate mapping of IL-17-producing T cells in inflammatory responses. Nature Immunology 12, 255-263.

Teixeira-Coelho, M., Cruz, A., Carmona, J., Sousa, C., Ramos-Pereira, D., Saraiva, A.L., Veldhoen, M., Pedrosa, J., Castro, A.G., and Saraiva, M. (2011). TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosis. International Immunology 23, 89-96

Martin, B., Hirota, K., Cua, D.J., Stockinger, B., and Veldhoen, M. (2009). Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31, 321-330.

Saraiva, M., Christensen, J.R., Veldhoen, M., Murphy, T.L., Murphy, K.M., and O'Garra, A. (2009). Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31, 209-219.

Bending, D., De La Pena, H., Veldhoen, M., Phillips, J.M., Uyttenhove, C., Stockinger, B., and Cooke, A. (2009). Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 119, 565–572.

Veldhoen, M., Hirota, K., Christensen, J., O'Garra, A., and Stockinger, B. (2009). Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. The Journal of Experimental Medicine 206, 43-49.

Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., and Stockinger, B. (2008). Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nature Immunology 9, 1341-1346.

Veldhoen, M., Hirota, K., Westendorf, A.M., Buer, J., Dumoutier, L., Renauld, J.C., and Stockinger, B. (2008). The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109.

Veldhoen, M., Hocking, R.J., Flavell, R.A., and Stockinger, B. (2006). Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nature Immunology 7, 1151-1156.

Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., and Stockinger, B. (2006). TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189.

Veldhoen, M., Moncrieffe, H., Hocking, R.J., Atkins, C.J., and Stockinger, B. (2006). Modulation of dendritic cell function by naive and regulatory CD4+ T cells. J Immunol 176, 6202-6210.

Useful Links

group leader : Marc Veldhoen
about
  • Group leader at iMM since 2016
  • Tenured Group leader, Babraham Institute, Cambridge, UK (2015-2016)
  • EMBO Young Investigator (2011)
  • Tenure track Group leader, Babraham Institute, Cambridge, UK (2010-2015)
  • Senior investigator scientist at NIMR, London, UK (2006-2010)
  • Postdoctoral research at NIMR, London, UK (2003-2006)
  • PhD Molecular Immunology, NIMR, London, UK (2003)