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Director´s Message

“Futuro” was the word that I picked when I was unexpectedly asked in a live national TV program for a word representing the turning of the year. While it was a totally spontaneous answer, there was a reason behind it. The entire program was dedicated to an analysis of 2018 and at one point I ended up thinking how much time we spend talking about things that obviously have a certain importance in a particular time and space but are just, as we say in Portuguese, “a espuma dos dias” (adapted from the French novel “L’Écume des jours”/ “Froth on the daydream”).

For the past 4 years we have been restructuring iMM with the concept that our overarching mission is the promotion of scientific excellence, leveraged by top quality human resources that are supported by state-of-the-art infrastructures. We have a strong conviction that we are moving towards a solid and at the same time a genuine environment, excited with the world to discover. However, 2018 was the year that we – Bruno Silva-Santos and myself – felt the need to define a more ambitious strategy for iMM in the years to come.

We must aim to foster new and disruptive discoveries, based on AMBITION, one of iMM’s key values. While FREEDOM will continue to be another of those key values, we must create room for bold initiatives based on interdisciplinary interactions.

Furthermore, to attract and maintain a vibrant faculty, we must invest in internationalization and enforce a recruitment, evaluation and promotion path based solely on professional excellence.

The success of such a structure also requires us, as community, to be fully committed to train and educate the most promising researchers to succeed in internationally competitive environments of academia, industry and clinical medicine. We should nurture the future leaders. Our MSc, PhD and post-doctoral programs must explore the fundamentals of living systems at all levels, while providing an intensive and demanding period of development of transferable skills. Being in the campus of and belonging to the Lisbon Medical Academic Centre (CAML), which includes the largest medical school (Faculdade de Medicina da Universidade de Lisboa - FMUL) and university hospital (Hospital Santa Maria - HSM) in the country, we must play a unique role in the scientific training of MD interns to ensure a new generation of Clinician-Scientists capable of bridging basic and clinical research.

We have no doubts that outstanding science is the motor of groundbreaking applications with societal impact. In that respect, 2018 was a very special year. After 5 years of pioneering research and development, one of iMM startups – Lymphact – was acquired in June 2018 by Gamma-Delta Therapeutics, a UK-based company. Lymphact, which was started upon a discovery made by iMM PhD student Daniel Correia in the team led by Bruno Silva-Santos, created a new technology to generate autologous and heterologous cellular immune therapies targeting chemotherapy-resistant cancer cells believed to cause disease recurrence. The iMM team will continue to work now with the UK team to develop their invention – DOT-Cells® – towards clinical application.

This process made clear the need to deploy improved streamlined processes to create a favorable environment to foster innovation and speed up the development of promising ideas to improve human life. This environment will ensure a strong interaction between our scientists and key stakeholders in industry, academia and the healthcare system towards clinical translation and commercialization, but always preserving the superior public interest. With that in mind, we have established a new Technology Transfer Office (TTO) fully dedicated to the valorization of iMM research, including the protection of intellectual property, partnering with industry, the promotion of entrepreneurship and the creation of new ventures as a key strategy to drive iMM innovation to the market. Bringing iMM innovation to clinical application will greatly benefit from a close collaboration with our founder HSM, which should reinforce our capacity to promote investigator-initiated trials in our medical research campus.

Last but not the least, while we aim to continue sharing our discoveries and enthusiasm in a range of public events and activities, we now also ambition to involve the entire society, contributing constructively to the public debate about the direction, purpose and implications of biomedical research. We are reinforcing iMM’s vocation to the service of the society and the pursue of knowledge dissemination in its two distinct but complementary versions: the most visible, which captivates by the results achieved, by the discovery; with the version that precedes it, the first encounter with the question and with the curiosity that is pursued. In this context, 2018 was also very rich.

First, we have created the Societal Advisory Board (SoAB), composed by distinguished members of our society, who will provide advice on public policies that adequately promote the values of iMM to the society. Second, we have launched the first campaign to introduce the iMM to the common nonscientist citizen. Under the motto “Behind a great answer, there is always the right question” we launched a series of posters in the Lisbon area (with a special focus in the surroundings of the university campus) with questions that we think might be posed by both scientists and non-scientists. Through a QR code in each poster, curious people could access a short video where an iMM scientist provided a simple but rigorous and easy to understand answer. We strongly believe this was just the beginning, as numerous contacts and questions received from the outside will certainly drive us into future adventures.

In the turning of the millennium, Melinda and Bill Gates decided they will help eradicating malaria before they die. Almost twenty years later, and just recently, another philanthropic and younger couple decided to leave an even stronger mark. Priscilla Chan and Mark Zuckerberg have provided 3 billion US dollars for the next 10 years with the ambitious goal to “cure, prevent and manage” all diseases. While such value is incredibly impressive, it is not a huge sum for such an ambitious goal. Notably, Chan and Zuckerberg know they just want to be the spark that triggers a process – to create a long-term global movement to finance science with the support of citizens around the world – that will allow them to achieve their goal. iMM wants to be part of such movement and contribute significantly to improve human health. To that end, in 2018 we have launched João Lobo Antunes Fund where we hope to engage the Portuguese society in supporting iMM scientists to address the most difficult questions, the questions that no one has yet asked or have not been answered yet. More importantly, the questions that have the potential to produce the most relevant answers.

Maria M. Mota (Executive Director)

Vibrant Scientific Environment

The iMM – Instituto de Medicina Molecular João Lobo Antunes is a leading Portuguese private non-profit research institute that offers a vibrant scientific environment, aiming to nurture innovative ideias in basic, clinical and translational biomedical research.

Created in 2002, iMM has established itself as a leading national and internationally competitive biomedical institute. Its strategy has been defined by promotion of excellence, leveraged by high-quality human resources, increasing expenditure in infrastructures and knowledge transfer to the society. iMM is an inclusive, equal opportunity employer offering attractive conditions and benefits.

Projects co-funded by FEDER through POR Lisboa 2020 - Programa Operacional Regional de Lisboa, PORTUGAL 2020 and by Fundação para a Ciência e a Tecnologia

Projects | Concurso 02/SAICT/2017

Projects | Concurso 03/SAICT/2015

Projects | Concurso ICDT2014

Vision, Mission & Values

Our Goal:

To pave the way for groundbreaking science.


Our Vision:

To improve human life through excellence in biomedical research.


Our Mission:

  • To promote basic biomedical, clinical, translational and innovation research in these areas, with the aim of contributing to a better understanding of disease mechanisms, to develop new diagnostic or predictive tests as well as new therapies.
  • To support postgraduate scientific training of young graduates, doctors and other health professionals.
  • To support scientific dissemination and the provision of services abroad in the areas of specialized diagnosis, quality control and collaboration in National and International Commissions related to Health.

Our Values:

Generation of knowledge, excellence, individual freedom and ambition.

Organization & Structure

iMM Associate Members

Universidade de Lisboa
Faculdade de Medicina da Universidade de Lisboa
Hospital Santa Maria
Associação para a Investigação e o Desenvolvimento da Faculdade de Medicina
Fundação Oriente


Boards of Trustees

The Board of Trustees is composed by representatives of the Associated Members and meets at least once per year to analyze the scientific and finance report and to approve the plan of activities and budget for the next year.


Board of Directors

The Board of Directors is responsible for the management of the Institute according to the Plans aprooved by the Trustees. The Board of Directors is elected by the Trustees.

M. Carmo-Fonseca
MD, PhD - President

Maria M. Mota
PhD - Executive Director

Bruno Silva-Santos
PhD - Vice-President

For any topic related to iMM Board of Directors or iMM President, please contact:
- Clara Artur (Assistant to the Board of Directors)
clara.artur@medicina.ulisboa.pt
- Patricia Cucio (Assistant to the President)
pcucio@medicina.ulisboa.pt


Finance and Operations Director

Fausto Lopo de Carvalho


Scientific Advisory Council

Undertake periodic evaluations to the iMM specific programes and include international experts of scientific fields.

Carlos Caldas
MD, PhD, Chairman
Cancer Research UK Cambridge Institute
Cambridge Cancer Center, UK

Yasmine Belkaid
PhD - National Institutes of Health

Elaine Mardis
PhD - Institute for Genomic Medicine at NationWide Children's Hospital

Caetano Reis e Sousa
PhD - Francis Crick Institute
London, UK

Paul Peter Tak
MD, PhD - University of Amesterdam
Netherlands


Societal Advisory Board

António Barreto
Chairman

Graça Franco

Paula Martinho da Silva

Diogo Lucena

João Filipe Queiro

Henrique Leitão

Pedro Norton

Domítilia dos Santos


Industrial Advisory Board

Daniela Couto
Biogeneration Ventures Fund

David Malta
Vesalius Biocapital

Isabel Ferreira
Versameb

Miguel Forte
Zelluna Immunotherapy

Pascale Redig
Janssen

Quality Policy

  • Support Instituto de Medicina Molecular João Lobo Antunes (iMM) Researchers to successfully pursue their missions.
  • Identify the needs for improvement in the technical, logistics and administrative areas in order to satisfy the needs/expectations of Customers, and promote the necessary measures to solve the difficulties that arise during the course of their activity.
  • To promote interaction between the scientific community of iMM and its different social partners, including academic institutions and health and industry, to foster scientific development.
  • Comply with requirements and improve the effectiveness of the Quality Management System.

Publications 2019

Ana Espada de Sousa Lab

Blanco E, Pérez-Andrés M, Arriba-Méndez S, Serrano C, Criado I, Del Pino-Molina L, Silva S, Madruga I, Bakardjieva M, Martins C, Serra-Caetano A, Romero A, Contreras-Sanfeliciano T, Bonroy C, Sala F, Martín A, Bastida JM, Lorente F, Prieto C, Dávila I, Marcos M, Kalina T, Vlkova M, Chovancova Z, Cordeiro AI, Philippé J, Haerynck F, López-Granados E, Sousa AE, van der Burg M, van Dongen JJM, Orfao A; EuroFlow PID group (2019). Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies. The Journal of Allergy and Clinical Immunology 144(3):809-824.

Carvalho S, Marcelino J, Duarte F, Costa C, Pereira Barbosa M, Pereira Santos MC (2019). Characterization of population of patients with fish allergy and contribution of recombinant Parvalbumin Gad c 1 in diagnosis and prognosis. Journal of Investigational Allergology and Clinical Immunology.

Cosme J, Spinola Santos A, Pereira Santos MC, Pereira Barbosa M (2019). Salmon roe as an emergent allergen in western countries. Journal of Investigational Allergology and Clinical Immunology 29(2):139-141.

Cosme J, Spínola Santos A, Pereira Santos MC, Pereira Barbosa M (2019). Venom Immunotherapy: a 20-year experience with an ultra-rush protocol (210-min). European Annals of Allergy and Clinical Immunology 51(3):122-128.

Dorhoi A, Glaría E, Garcia-Tellez T, Nieuwenhuizen NE, Zelinskyy G, Favier B, Singh A, Ehrchen J, Gujer C, Münz C, Saraiva M, Sohrabi Y, Sousa AE, Delputte P, Müller-Trutwin M, Valledor AF (2019). MDSCs in infectious diseases: regulation, roles, and readjustment. Cancer Immunology Immunotherapy 68(4):673-685.

Duarte RF, Ornelas C, Silva S, Morgado R, Pereira D, Escaleira D, Moreira S, Valença J, Pedro E, Branco Ferreira M, Pereira Santos MC, Pereira Barbosa M (2019). Contribution of in vivo and in vitro testing for the diagnosis of local allergic rhinitis. Journal of Investigational Allergology and Clinical Immunology 29(1):46-48.

Fernandes M, Lourenço T, Lopes A, Spínola Santos A, Pereira Santos MC, Pereira Barbosa M (2019). Chlorhexidine: a hidden life-threatening allergen. Asia Pacific Allergy 9(4):e29.

Godinho-Santos A, Foxall RB, Antão AV, Tavares B, Ferreira T, Serra-Caetano A, Matoso P, Sousa AE (2019). Follicular Helper T Cells Are Major Human Immunodeficiency Virus-2 Reservoirs and Support Productive Infection. The Journal of Infectious Diseases 221(1):122-126.

McDermott DH, Pastrana DV, Calvo KR, Pittaluga S, Velez D, Cho E, Liu Q, Trout HH 3rd, Neves JF, Gardner PJ, Bianchi DA, Blair EA, Landon EM, Silva SL, Buck CB, Murphy PM (2019). Plerixafor for the Treatment of WHIM Syndrome. New England Journal of Medicine 380(2):163-170.

Miranda M, Martins AT, Carvalho S, Serra-Caetano A, Esteves I, Marques JG (2019). Vacinas Vivas em Crianças com Síndrome de DiGeorge/ Deleção 22q11.2. Acta Médica Portuguesa 32(7–8):514–19.

Pereira Santos MC, Lourenço T, Pedro E, Pereira Barbosa M, Branco Ferreira M (2019). Evolution of Api m10 specific IgE and IgG4 after one year of bee venom immunotherapy. European Annals of Allergy and Clinical Immunology.

Santos MCP, Serra-Caetano A, Pedro E, Melo A, Caramalho I, Barbosa MP, Victorino RMM, Sousa AE (2019). Expansion of FOXP3+ regulatory CD4 T-cells upon exposure to hymenoptera venom during the beekeeping season. Allergy 74(6):1182-1184.

Silva SL, Fonseca M, Pereira MLM, Silva SP, Barbosa RR, Serra-Caetano A, Blanco E, Rosmaninho P, Pérez-Andrés M, Sousa AB, Raposo AASF, Gama-Carvalho M, Victorino RMM, Hammarstrom L, Sousa AE (2019). Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden. Frontiers in Immunology 10:2503.

Smets F, Dobbelaere D, McKiernan P, Dionisi-Vici C, Broué P, Jacquemin E, Lopes AI, Gonçalves I, Mandel H, Pawlowska J, Kamińska D, Shteyer E, Torre G, Shapiro R, Eyskens F, Clapuyt P, Gissen P, Pariente D, Grunewald S, Yudkoff M, Binda MM, Najimi M, Belmonte N, Vos B, Thonnard J, Sokal E (2019). Phase I/II Trial of Liver Derived Mesenchymal Stem Cells in Pediatric Liver Based Metabolic Disorders: A Prospective, Open Label, Multicenter, Partially Randomized, Safety Study of One Cycle of Heterologous Human Adult Liver-Derived Progenitor Cells (HepaStem®) in Urea Cycle Disorders and Crigler-Najjar Syndrome patients. Transplantation 103(9):1903-1915.

van der Burg M, Kalina T, Perez-Andres M, Vlkova M, Lopez-Granados E, Blanco E, Bonroy C, Sousa AE, Kienzler AK, Wentink M, Mejstríková E, Šinkorova V, Stuchly J, van Zelm MC, Orfao A, van Dongen JJM (2019). The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System. Frontiers in Immunology 10:246.

van Dongen JJM, van der Burg M, Kalina T, Perez-Andres M, Mejstrikova E, Vlkova M, Lopez-Granados E, Wentink M, Kienzler AK, Philippé J, Sousa AE, van Zelm MC, Blanco E, Orfao A (2019). EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid System. Frontiers in Immunology 10:1271.


Ana Sebastião Lab

Branco MA, Cotovio J, Rodrigues CAV, Vaz SH, Fernandes TG, Moreira LM, Cabral JMS, Diogo MM (2019). Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Maturation Compared to 2D Culture. Scientific Reports 9:9229. Original paper.

Chern Y, Rei N, Ribeiro JA, Sebastião AM (2019). Adenosine and its receptors as potential drug targets in amyotrophic lateral sclerosis (ALS). Journal of Caffeine and Adenosine Research 9:157-166. Review.

Fonseca-Gomes J, Jerónimo-Santos A, Lesnikova A, Casarotto P, Castrén E, Sebastião AM, Diógenes MJ (2019). TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins. Frontiers Molecular Neurosciences 1:12:4. Original paper.

Gomes C, Cunha C, Nascimento F, Ribeiro JA, Vaz AR, Brites D (2019). Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model. Molecular Neurobiology 56:2137-2158.

Gonçalves-Ribeiro J, Pina CC, Sebastião AM, Vaz SH (2019). Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity. Frontiers in Cellular Neuroscience 13:357. Review.

Marcelino H, Nogueira VC, Santos CRA, Quelhas P, Carvalho TMA, Fonseca-Gomes J, Tomás J, Diógenes MJ, Sebastião AM, Cascalheira JF (2019). Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation. Journal of Neurochemistry 7:e14937. Original paper.

Marques M, Albuquerque I, Vaz SH, Bernardes G (2019). Overexpression of osmosensitive Ca2+ activated channel TMEM63B promotes migration in HEK293T cell. Biochemistry 58:2861-2866. Original paper.

Mateus JM, Ribeiro FF, Gomes MA, Rodrigues RS, Marques JM, Sebastião AM, Rodrigues RJ, Xapelli S (2019). Neurogenesis and gliogenesis: relevance of adenosine for neuroregeneration in brain disorders. Journal of Caffeine and Adenosine Research 9:129-144. Review.

Mouro FM, Köfalvi A, André LA, Baqi Y, Christa E Müller CE, Ribeiro JA, Sebastião AM (2019). Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism. Neuropharmacology 155:10-21.

Mouro FM, Miranda-Lourenço C, Sebastião AM, Diógenes MJ (2019). From Cannabinoids and Neurosteroids to Statins and the Ketogenic Diet: New Therapeutic Avenues in Rett Syndrome? Frontiers in Neurosciences 2:1.

Ribeiro M, Brigas HC, Temido-Ferreira M, Pousinha PA, Regen T, Santa C, Coelho JE, Marques-Morgado I, Valente CA, Omenetti S, Stockinger B, Waisman A, Manadas B, Lopes LV, Silva-Santos B, Ribot JC (2019). Meningeal γδ T cell–derived IL-17 controls synaptic plasticity and short-term memory. Science Immunology 4(40):eaay5199.

Rodrigues RS, Lourenço DM, Paulo SL, Mateus JM, Ferreira MF, Mouro FM, Moreira JB, Ribeiro FF, Sebastião AM, Xapelli S (2019). Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology. Molecules 24(7). Review.

Ruffolo G, Cifelli P, Miranda-Lourenço C, De Felice E, Limatola C, Sebastião AM, Diógenes MJ, Aronica E, Palma E (2019). Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome. Neuroscience pii:S0306-4522(19)30421-X. Original paper.


Bruno Silva-Santos Lab

Caiado F, Maia-Silva D, Jardim C, Schmolka N, Carvalho T, Reforço C, Faria R, Kolundzija B, Simões AE, Baubec T, Vakoc CR, da Silva MG, Manz MG, Schumacher TN, Norell H, Silva-Santos B (2019). Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection. Nature Communications 10(1):4986.

Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis E Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European Journal of Immunology 49(10):1457-1973.

Di Lorenzo B, Ravens S, Silva-Santos B (2019). High-throughput analysis of the human thymic Vδ1+ T cell receptor repertoire. Scientific Data 6(1):115.

Di Lorenzo B, Simões AE, Caiado F, Tieppo P, Correia DV, Carvalho T, da Silva MG, Déchanet-Merville J, Schumacher TN, Prinz I, Norell H, Ravens S, Vermijlen D, Silva-Santos B (2019). Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells. Cancer Immunology Research 7(4):552-558. 

Mikulak J, Oriolo F, Bruni E, Roberto A, Colombo FS, Villa A, Bosticardo M, Bortolomai I, Lo Presti E, Meraviglia S, Dieli F, Vetrano S, Danese S, Della Bella S, Carvello MM, Sacchi M, Cugini G, Colombo G, Klinger M, Spaggiari P, Roncalli M, Prinz I, Ravens S, di Lorenzo B, Marcenaro E, Silva-Santos B, Spinelli A, Mavilio D (2019). NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer. Journal of Clinical Investigation Insight 4(24).

Ribeiro M, Brigas HC, Temido-Ferreira M, Pousinha PA, Regen T, Santa C, Coelho JE, Marques-Morgado I, Valente CA, Omenetti S, Stockinger B, Waisman A, Manadas B, Lopes LV, Silva-Santos B, Ribot JC (2019). Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory. Science Immunology 4(40).

Ribot JC, Neres R, Zuzarte-Luís V, Gomes AQ, Mancio-Silva L, Mensurado S, Pinto-Neves D, Santos MM, Carvalho T, Landry JJM, Rolo EA, Malik A, Silva DV, Mota MM, Silva-Santos B, Pamplona A (2019). γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection. Proceedings of the National Academy of Sciences 116(20):9979-9988.

Sebestyen Z, Prinz I, Déchanet-Merville J, Silva-Santos B, Kuball J (2019). Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies. Nature Reviews Drug Discovery 19(3):169-184. Review.

Silva-Santos B, Mensurado S, Coffelt SB (2019). γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer. Nature Reviews Cancer 19(7):392-404. Review.

Staats R, Rodrigues R, Barros A, Bacelar-Nicolau L, Aguiar M, Fernandes D, Moreira S, Simões A, Silva-Santos B, Rodrigues JV, Barbara C, de Almeida AB, Ferreira Moita LF (2019). Role of CD3+γδ-T cells in the association of obstructive sleep-disordered breathing and cancer. Sleep and Breathing April.

Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz I, Ravens S (2019). Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. Cell Reports 27(12):3657-3671.


Cláudio Franco Lab

Barbacena P, Ouarné M, Haigh JJ, Vasconcelos FF, Pezzarossa A, Franco CA (2019). GNrep mouse: A reporter mouse for front-rear cell polarity. Genesis 57(6):e23299.

Carvalho JR, Fortunato IC, Fonseca CG, Pezzarossa A, Barbacena P, Dominguez-Cejudo MA, Vasconcelos FF, Santos NC, Carvalho FA, Franco CA (2019). Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration. eLife 8:e45853.

Hendrikx S, Coso S, Prat-Luri B, Wetterwald L, Sabine A, Franco CA, Nassiri S, Zangger N, Gerhardt H, Delorenzi M, Petrova TV (2019). Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2. Cell Reports 26(5):1227-1241.e6.


Claus Azzalin Lab

Domingues-Silva B, Silva B, Azzalin CM (2019). ALTernative functions for human FANCM at telomeres. Frontiers in Molecular Biosciences 6:UNSP84. Review.

Hu Y, Bennett HW, Liu N, Moravec M, Williams JF, Azzalin CM, King MC (2019). RNA-DNA hybrids support recombination-based telomere maintenance in fission yeast. Genetics 213(2):431-447.

Silva B, Pentz R, Figueira AM, Arora R, Lee YW, Hodson C, Wischnewski H, Deans AJ, Azzalin CM (2019). FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops. Nature Communications 10:e2253.


Gonçalo Bernardes Lab

Adusumalli SR, Bernardes GJL* (2019). Ethynylbenziodoxolone reactivity in cysteine bioconjugation. Chem 5(8):1924–1937.

Akkapeddi P, Fragoso R, Hixon JÁ, Ramalho AS, Oliveira ML, Carvalho T, Gloger A, Matasci M, Corzana F, Durum SK, Neri D, Bernardes GJL*, Barata JT* (*co-senior authors) (2019). A fully human anti-IL-7Rα antibody promotes anti-tumor activity against T-cell acute lymphoblastic leukemia. Leukemia 33(9):2155–2168.

Alcock LJ, Oliveira BL, Deery MJ, Pukala TL, Perkins MV, Bernardes GJL*, Chalker JM* (*co-senior authors) (2019). Norbornene probes for the detection of cysteine sulfenic acid in cells. ACS Chemical Biology 14(4):594–598.

Amorim AL, Peterle MM, Guerreiro A, Coimbra DF, Heying RS, Caramori GF, Braga AL, Bortoluzzi AJ, Neves A, Bernardes GJL, Peralta RA (2019). Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs. Dalton Transactions 48(17):5574–5584.

António J, Russo R, Carvalho C, Cal P, Góis P (2019). Boronic acids as building blocks for the construction of therapeutically useful bioconjugates. Chemical Society Reviews 48(13):3513-36.

Baker C, Rodrigues T, de Almeida BP, Barbosa-Morais NL, Bernardes GJL* (2019). Natural product-drug conjugates for modulation of TRPV1-expressing tumors. Bioorganic & Medical Chemistry 27(12):2531–2536.

Bernardim B, Matos MJ, Ferhati X, Compañón I, Guerreiro A, Akkapeddi P, Burtoloso ACB, Jiménez-Osés G, Corzana F, Bernardes GJL* (2019). Efficient and irreversible antibody-cysteine bioconjugation using carbonylacrylic reagents. Nature Protocols 14(1):86–99.

Compañón I, Guerreiro A, Mangini V, Castro-López J, Escudero-Casao M, Avenoza A, Busto JH, Castillón S, Jiménez-Barbero J, Asensio JL, Jiménez-Osés G, Boutureira O, Peregrina JM, Hurtado-Guerrero R, Fiammengo R, Bernardes GJL*, Corzana F* (*co-senior authors) (2019). Structure-based design of potent tumor-associated antigens: Modulation of peptide presentation by single-atom O/S or O/Se substitutions at the glycosidic linkage. Journal of the American Chemical Society 141(9):4063–4072.

Davies S, Oliveira B, Bernardes GJL* (2019). Development of a self-immolative linker for tetrazine-triggered release of alcohols in cells. Organic & Biomolecular Chemistry 17(23):5725–5730.

Davies S, Qiao J, Oliveira BL, Navoc CD, Jiménez-Osés G, Bernardes GJL* (2019). Tetrazine-triggered release of carboxylic-acid containing molecules for activation of an anti-inflammatory drug. ChemBioChem 20(12):1541–1546.

Gil de Montes E, Jiménez-Moreno E, Oliveira BL, Navo CD, Cal PMSD, Jiménez-Osés G, Robina I, Moreno-Vargas AJ, Bernardes GJL* (2019). Azabicyclic vinyl sulfones for residue-specific dual protein labelling. Chemical Science 10(16):4515–4522.

Hoyt EA, Cal PMSD, Oliveira BL, Bernardes GJL* (2019). Contemporary approaches to site-selective protein modification. Nature Reviews Chemistry 3(3):147–171.

Lindstedt PR, Aprile FA, Matos MJ, Perni M, Bertoldo JB, Bernardim B, Peter Q, Jiménez-Osés G, Knowles TPJ, Dobson CM, Corzana F, Vendruscolo M, Bernardes GJL* (2019). Enhancement of the anti-aggregation activity of a molecular chaperone using a rationally designed post-translational modification. ACS Central Science 5(8):1417-1424.

Marques MC, Albuquerque IS, Vaz SH, Bernardes GJL* (2019). Overexpression of osmosensitive Ca2+-permeable channel TMEM63B promotes migration in HEK293T cells. Biochemistry 58(26):2861–2866.

Matos MJ, Jiménez-Osés G, Bernardes GJL* (2019). Lysine bioconjugation on native albumin with a sulfonyl acrylate reagent. Methods in Molecular Biology 2033:25–37.

Matos MJ, Navo CD, Hakala T, Ferhati X, Guerreiro A, Hartmann D, Bernardim B, Saar KL, Compañón I, Corzana F, Knowles TPJ, Jiménez-Osés G, Bernardes GJL* (2019). Quaternization of vinyl/alkynyl pyridine enables ultrafast cysteine-selective protein modification and charge modulation. Angewandte Chemie-International Edition 58(20):6640–6644.

Motloch P, Guerreiro A, Azeredo CQ, Bernardes GJL*, Hunter CA, Kocsis I (2019). Triaminopyrimidine derivatives as transmembrane HCl transporter. Organic & Biomolecular Chemistry 17(22):5633–5638.

Reker D, Bernardes GJL, Rodrigues T (2019). Computational advances in combating colloidal aggregation in drug discovery. Nature Chemistry 11(5):402–418.

Rodrigues T, de Almeida BP, Barbosa-Morais NL, Bernardes GJL* (2019). Dissecting celastrol with machine learning to unveil dark pharmacology. Chemical Communications 55(45):6369–6372.

Silva D-A, Yu S, Ulge U, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley S, Marcos E, Walkey CD, Weitzner BD, Pardo-Avila F, Carter L, Stewart L, Riddell S, Pepper M, Bernardes GJL, Dougan M, Garcia C, Baker D (2019). De novo design of potent and selective mimics of IL-2/IL-15. Nature 565(7738):186–191.

Sun S, Akkapeddi P, Marques MC, Martínez-Sáez N, Torres VM, Cordeiro C, Boutureira O, Bernardes GJL* (2019). One-pot stapling of interchain disulfides of antibodies using an isobutylene motif. Organic & Biomolecular Chemistry 17(7):2005–2012. 

Traquete R, Henderson E, Picaud S, Cal PMSD, Sieglitz F, Rodrigues T, Oliveira R, Filippakopoulos P, Bernardes GJL* (2019). Evaluation of linker length effects on a BET bromodomain probe. Chemical Communications 55(68):10128–10131.

Zwicker VE, Oliveira BL, Yeo JH, Fraser ST, Bernardes GJL, New EJ, Jolliffe KA (2019). A fluorogenic probe for cell surface phosphatidylserine using an intramolecular indicator displacement sensing mechanism. Angewandte Chemie-International Edition 58(10):3087–3091.


Joana Neves Lab

Munoz-Canoves P**, Neves J, Sousa-Victor P** (2019). Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells. FEBS Journal 287(3):406416. Review.

Neves J**, Sousa-Victor P** (2019). Regulation of inflammation as an anti-aging intervention. FEBS Journal 287(2020):43–52. Perspective.

Sousa-Victor P*, Neves J*, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soife I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H (2019). MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nature Metabolism 1(2): 276–290.


João Barata Lab

Barata JT (2019). Introduction to the special issue on T-cell acute lymphoblastic leukemia genetics, biology and therapeutics. Advances in Biological Regulation 74:100671. Editorial.

Barata JT, Durum SK, Seddon B (2019). Flip the coin: IL-7 and IL-7R in health and disease. Nature Immunology 20(12):1584-1593. 

Buffière A, Uzan B, Aucagne R, Hermetet F, Mas M, Nassurdine S, Aznague A, Carmignac V, Tournier B, Bouchot O, Ballerini P, Barata JT, Bastie JN, Delva L, Pflumio F, Quéré R (2019). T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7. Oncogene 39(5):975-986.

Correia NC*, Barata JT* (2019). MicroRNAs and their involvement in T-ALL: A brief overview. Advances in Biological Regulation 74:100650.

de Medeiros CB, Moxon-Emre I, Scantlebury N, Malkin D, Ramaswamy V, Decker A, Law N, Kumabe T, Leonard J, Rubin J, Jung S, Kim SK, Gupta N, Weiss W, Faria CC, Vibhakar R, Lafay-Cousin L, Chan J, Kros JM, Janzen L, Taylor MD, Bouffet E, Mabbott DJ (2019). Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort. Cancer Medicine 9(2):447-459.

Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C (2019). Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nature Communications 10(1):4343.

Hixon JA, Andrews C, Kashi L, Kohnhorst CL, Senkevitch E, Czarra K, Barata JT, Li W, Schneider JP, Walsh STR, Durum SK (2019). New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia 34(1):35-49.

Oliveira ML, Akkapeddi P, Ribeiro D, Melão A, Barata JT (2019). IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update. Advances in Biological Regulation 71:88-96.

P. Akkapeddi, R. Fragoso, J.A. Hixon, A.S. Ramalho, M.L. Oliveira, T. Carvalho, A. Gloger, M. Matasci, F. Corzana, S.K. Durum, D. Neri, G.J.L. Bernardes*, J.T. Barata* (2019). A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia. Leukemia 33(9):2155-2168.

Pinto I, Duque M, Gonçalves J, Akkapeddi P, Oliveira ML, Cabrita R, Yunes JA, Durum SK, Barata JT, Fragoso R (2019). NRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling. Oncogene 39(5):975-986.

Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, Momin A, Wang J, Dong W, Kim SK, Grajkowska WA, Jouvet A, Fèvre-Montange M, Garrè ML, Nageswara Rao AA, Giannini C, Kros JM, French PJ, Jabado N, Ng HK, Poon WS, Eberhart CG, Pollack IF, Olson JM, Weiss WA, Kumabe T, López-Aguilar E, Lach B, Massimino M, Van Meir EG, Rubin JB, Vibhakar R, Chambless LB, Kijima N, Klekner A, Bognár L, Chan JA, Faria CC, Ragoussis J, Pfister SM, Goldenberg A, Wechsler-Reya RJ, Bailey SD, Garzia L, Morrissy AS, Marra MA, Huang X, Malkin D, Ayrault O, Ramaswamy V, Puente XS, Calarco JA, Stein L, Taylor MD (2019). Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature 574(7780):707-711.


João Eurico da Fonseca Lab

Águeda AF, Monti S, Luqmani RA, Buttgereit F, Cid M, Dejaco C, Mahr A, Ponte C, Salvarani C, Schmidt WA, Hellmich B (2019). Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis. RMD Open 5(2):e001020. (IF: 3.47, Citations: 0. Source: Web of Science).Águeda AF, Monti S, Luqmani RA, Buttgereit F, Cid M, Dejaco C, Mahr A, Ponte C, Salvarani C, Schmidt WA, Hellmich B (2019). Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis. RMD Open 5(2):e001020.

Amaro D, Carreño E, Steeples LR, Oliveira-Ramos F, Marques-Neves C, Leal I (2019). Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review. The British Journal of Ophthalmology.

Antunes M, Scirè CA, Talarico R, Alexander T, Avcin T, Belocchi C, Doria A, Franceschini F, Galetti I, Govoni M, Hachulla E, Launay D, Lepri G, Macieira C, Matucci-Cerinic M, Montecucco CM, Moraes-Fontes MF, Mouthon L, Paolino S, Ramoni V, Tani C, Tas SW, Tincani A, Van Vollenhoven R, Zen M, Fonseca J, Bombardieri S, Fonseca JE, Schneider M, Smith V, Cutolo M, Mosca M, Beretta L (2019). Undifferentiated connective tissue disease: state of the art on clinical practice guidelines. RMD Open 4(Suppl 1):e000786. Review.

Araújo FC, Gonçalves J, Fonseca JE (2019). Biosimilars in Rheumatology. Pharmacology Research 149:UNSP104467. Review.

Bergstra SA, Winchow LL, Murphy E, Chopra A, Salomon-Escoto K, Fonseca JE, Allaart CF, Landewé RBM (2019). How to treat patients with rheumatoid arthritis when methotrexate has failed? The use of a multiple propensity score to adjust for confounding by indication in observational studies. Annals of the Rheumatic Diseases 78:25-30.

Boel A, Moltó A, van der Heijde D, Ciurea A, Dougados M, Gensler LS, Santos MJ, de Miguel E, Poddubnyy D, Rudwaleit M, van Tubergen A, van Gaalen F, Ramiro S (2019). Do patients with axial spondyloarthritis with radiographic sacroiliitis fulfil both the modified New York criteria and the ASAS axial spondyloarthritis criteria? Results from eight cohorts. Annals of Rheumatic Diseases 78(11):1545-1549.

Brahe CH, Ørnbjerg L, Jacobsson L, Nissen M, Kristianslund EK, Santos MJ, Eklund K, Rotar Z, Gudbjornsson B, Onen F, Codreanu C, Lindström U, Gabay C, Kvien TK, Barcelos A, Aaltonen K, Tomšič M, Love TJ, Can G, Ionescu R, Loft AG, Mann H, Pavelka K, Van der Sande M, Van der Horst-Bruinsma IE, Reino JG, Sánchez-Piedra C, Macfarlane GJ, Iannone F, Hyldstrup LH, Krogh NS, Østergaard M, Hetland ML (2019). Retention and response rates in 14,261 psoriatic arthritis patients starting TNF inhibitor treatment – results from 12 countries in EuroSpA. Rheumatology.

Canet LM, Sánchez-Maldonado JM, Cáliz R, Ramos AR, Lupiañez CB, Canhão H, Martínez-Bueno M4, Escudero A, Segura-Catena J, Sorensen SB, Hetland ML, Soto-Pino MJ, Ferrer MA, García A, Glintborg B, Filipescu I, Pérez-Pampin E, González-Utrilla A, Nevot MÁL, Conesa-Zamora P, Broeder AD, De Vita S, Jacobsen SEH, Collantes-Estevez E, Quartuccio L, Canzian F, Fonseca JE, Coenen MJH, Andersen V, Sainz J (2019). Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients. Pharmacogenomics Journal 19:83-96.

Duarte AC, Cordeiro A, Fernandes BM, Bernardes M, Martins P, Cordeiro I, Santiago T, Seixas MI, Ribeiro AR, Santos MJ (2019). Rituximab in connective tissue disease-associated interstitial lung disease. Clinical Rheumatology 38(7):2001-2009.

Geenen R, Overman CL, Christensen R, Åsenlöf P, Capela S, Huisinga KL, Husebø MEP, Köke AJA, Paskins Z, Pitsillidou IA, Savel C, Austin J, Hassett AL, Severijns G, Stoffer-Marx M, Vlaeyen JWS, Fernández-de-Las-Peñas C, Ryan SJ, Bergman S (2019). EULAR recommendations for the health professional’s approach to painmanagement in inflammatory arthitis and osteoartritis. Annals of the Rheumatic Diseases 77(6)797-807.

Gomes JL, Sepriano A, Eusébio M, Serra S, Fonseca JE, Saavedra MJ, Cunha-Miranda L, Silva C, Bernardes M, Rosa-Gonçalves D, Costa J, Castelão W, Branco JC, Santos MJ (2019). Predictors and causes of first-line biologic agent discontinuation in rheumatoid arthritis: data from Reuma.pt. Acta Reumatológica Portuguesa 44(1):57-64.

Gribbons KB, Ponte C, Carette S, Craven A, Cuthbertson D, Hoffman G, Khalidi N, Koening CL, Langford C, Maksimowicz-McKinnon K, McAlear C, Monach P, Moreland L, Pagnoux C, Quinn K, Robson JC, Seo P, Sreih AG, Suppiah R, Warrington KJ, Ytterberg S, Luqmani RA, Watts RA, Merkel PA, Grayson PC (2019). Patterns of Arterial Disease in Takayasu’s Arteritis and Giant Cell Arteritis. Arthritis Care & Research (Hoboken).

Gribbons KB, Ponte C, Craven A, Robson JC, Suppiah R, Luqmani RA, Watts RA, Merkel PA, Grayson PC (2019). Diagnostic Assessment Strategies and Disease Subsets in Giant Cell Arteritis: An International Observational Cohort. Arthritis & Rheumatology.

Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, Cassie R, Cid MC, Dasgupta B, Dejaco C, Hatemi G, Hollinger N, Mahr A, Mollan SP, Mukhtyar C, Ponte C, Salvarani C, Sivakumar R, Tian X, Tomasson G, Turesson C, Schmidt W, Villiger PM, Watts R, Young C, Luqmani RA (2019). 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Annals of the Rheumatic Diseases 79(1)19-30.

Lauper K, Mongin D, Alpizar-Rodriguez D, Codreanu C, Iannone F, Kristianslund EK, Kvien TK, Pavelka K, Pombo-Suarez M, Santos MJ, Gabay C, Finckh A, Courvoisier DS (2019). Drug retention of biological DMARD in rheumatoid arthritis patients: the role of baseline characteristics and disease evolution. Rheumatology (Oxford) 58(12):2221-2229.

Lauper K, Mongin D, Iannone F, Kristianslund EK, Kvien TK, Nordström DC, Pavelka K, Pombo-Suarez M, Rotar Z, Santos MJ, Codreanu C, Lukina G, Gale SL, John M, Luder Y, Courvoisier DS, Gabay C (2019). Comparative effectiveness of TNF inhibitors and tocilizumab with and without conventional synthetic disease-modifying antirheumatic drugs in a pan-European observational cohort of bio-naïve patients with rheumatoid arthritis. Seminars Arthritis Rheumatology 50(1):17-24.

Leal IC, Brogueira Rodrigues F, Sousa DC, Duarte G, Romão VC, Neves CM, Costa J, Fonseca JE (2019). Anti-TNF Drugs for Chronic Uveitis in Adults—A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Medicine 6:104.

Luís M, Brites A, Duarte A, Teixeira V, Freitas R, Oliveira-Ramos F, Macieira C, Santos M, Inês L (2019). How to diagnose lupus enteritis early? Lessons learned from a multicenter case series. Acta Reumatológica Portuguesa 44(2):145-150.

Macieira C, Cunha-Miranda L, Nero P, Laires P, Bogas M, Farinha S, Freitas I, Lucas P, Sousa J, Narciso L, Mateus E, Canas da Silva J, Fonseca JE, Study Group RS Rheuma SPACE – Standard (2019). Practice Aiming Clinical Excellence: description of the methodological approach. Acta Reumatológica Portuguesa.

Martins N, Antunes AP, Macieira C (2019). Neuromyelitis Optica Spectrum Disorder in a Patient With Systemic Lupus Erythematosus. Journal of Clinical Rheumatology 25(4):38-40.

Martins N, Polido-Pereira J, Caneira M, Fonseca JE (2019). Treatment of Persistent Cutaneous Atrophy After Corticosteroid Injection With Fat Graft. Reumatologia Clinica 15(6):e122-e124.

Martins P, Barreira SC, Melo AT, Campanilho-Marques R, Costa-Reis P, Fonseca JE, Oliveira-Ramos F (2019). Transition in a Paediatric Rheumatology Unit - experience from a tertiary unit. Acta Reumatológica Portuguesa.

Martins P, Fonseca JE (2019). How to investigate: Pre-clinical rheumatoid arthritis. Best Practice & Research in Clinical Rheumatology 33(4):UNSP101438.

Martins P, Marques D, Janeiro J, Romeu JC, Ponte C (2019). Tumoral calcinosis in a rheumatoid arthritis patient - a rare case report. Acta Reumatológica Portuguesa 44:158-160.

Martins P, Teixeira V, Saraiva F, Ponte C (2019). The geyser sign: an unusual presentation of a rotator cuff tear. Acta Reumatológica Portuguesa 44(2)155-157.

Meyer A, Scirè CA, Talarico R, Alexander T, Amoura Z, Avcin T, Barsotti S, Beretta L, Blagojevic J, Burmester G, Cavazzana I, Cherrin P, Damian L, Doria A, Fonseca JE, Furini F, Galetti I, Houssiau F, Krieg T, Maddalena L, Launay D, Campanilho-Marques R, Martin T, Matucci-Cerinic M, Moinzadeh P, Montecucco C, Moraes-Fontes MF, Mouthon L, Neri R, Paolino S, Piette Y, Rednic S, Tamirou F, Tincani A, Toplak N, Bombardieri S, Hachulla E, Mueller-Ladner U, Schneider M, Smith V, Vieira A, Cutolo M, Mosca M, Cavagna L (2019). Idiopathic inflammatory myopathies: state of the art on clinical practice guidelines [corrected]. RMD Open 4(Suppl 1):e000784.

Miltenberger-Miltenyi, G, Cruz-Machado, AR, Saville, J, Conceição, VA, Calado, A, Lopes, I, Fuller, M, Fonseca, JE (2019). Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients. Rheumatology kez545.

Mongin D, Lauper K,Turesson C, Hetland ML, Kristianslund EK, Kvien TK, Santos MJ, Pavelka K, Iannone F, Finckh A, Courvoisier DS (2019). Imputing missing data of function and disease activity in rheumatoid arthritis registers: what is the best technique? RMD Open 5(2):e00099.

Monti S, Águeda AF, Luqmani RA, Buttgereit F, Cid M, Dejaco C, Mahr A, Ponte C, Salvarani C, Schmidt WA, Hellmich B (2019). Systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis: focus on giant cell arteritis. RMD Open 5(2): e001003.

Monti S, Ponte C, Pereira C, Manzoni F, Klersy C, Rumi F, Carrara G, Hutchings A, Schmidt WA, Dasgupta B, Caporali R, Montecucco C, Luqmani RA (2019). The Impact Of Disease Extent And Severity Detected By Quantitative Ultrasound Analysis In The Diagnosis And Outcome Of Giant Cell Arteritis: Results From The Temporal Artery Biopsy Versus Ultrasound (Tabul) Study And Validation In An Independent Cohort. Rheumatology (Oxford).

Ørnbjerg L, Brahe CH, Askling J, Ciurea A, Mann H, Onen F, Kristianslund EK, Nordström D, Santos MJ, Codreanu C, Gómez Reino J, Rotar Z, Gudbjornsson B, DiGiuseppe D, Nissen M, Pavelka K, Can G, Kvien TK, Eklund KK, Barcelos A, Ionescu R, Sánchez-Piedra C; Tomšič M, Geirsson AJ, Rusman T, Jones G, Iannone F, Hyldstrup LH, Krogh NS, Hetland ML, Østergaard M (2019). Treatment response and drug retention rates in 24,195 biologic-naïve patients with axial spondyloarthritis initiating TNFi treatment – routine care data from 12 registries in the EuroSpA collaboration. Annals of the Rheumatic Diseases 78(11):1536-1544.

Pereira E Silva R, Romão VC, Neves M, Garcia R, Oliveira S, Brites J, Ramos FO, Canhão H, Palma Dos Reis J, Pereira da Silva JA, Lopes T (2019). Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome. Lupus 28(1)27-33.

Polido-Pereira J (2019). Ultrasound-Guided Biopsies: Medium and Large Joints. Frontiers in Medicine (Lausanne) 6:95. Review.

Polido-Pereira J*, Serra S*, Teixeira F*, Ponte C, Cerqueira M, Cruz M, Araújo F, Barros R, Costa T, Faria D, Lopes C, Madruga-Dias J, Oliveira M, Teixeira RL, Vilar A, Falcão S, Saraiva F, Figueiredo G *These authors contributed equally to this manuscript (2019). Portuguese recommendations for the use of ultrasound in rheumatology. Acta Reumatológica Portuguesa 44(1):7-28.

Ponte C, Martins-Martinho J, Luqmani RA (2019). Diagnosis of Giant Cell Arteritis. Rheumatology (Oxford).

Ramos-Casals M, Brito-Zerón P, Bombardieri S, Bootsma H, De Vita S, Dörner T, Fisher BA, Gottenberg JE, Hernandez-Molina G, Kocher A, Kostov B, Kruize AA, Mandl T, Ng WF, Retamozo S, Seror R, Shoenfeld Y, Sisó-Almirall A, Tzioufas AG, Vitali C, Bowman S, Mariette X, EULAR-Sjögren Syndrome Task Force Group (2019). EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies. Annals of the Rheumatic Diseases 79(1):3-18.

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C, PEAC- R4RA investigators (2019). B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Arthritis Rheumatology.

Rocha FAC, Girão VCC, Nunes RM, Pinto ACMD, Vidal B, Fonseca JE (2019). Cell sources of inflammatory mediators present in bone marrow areas inside the meniscus. PLoS One 14(12):e0226986.

Rodrigues AM, Eusébio M, Rodrigues AB, Caetano-Lopes J, Lopes IP, Lopes A, Mendes JM, Coelho PS, Fonseca JE, Branco JC, Canhão H (2019). Low serum levels of DKK2 predict incident low-impact fracture in older women. JBMR Plus 3(7):e10179.

Romão VC, Fonseca JE (2019). Major challenges in Rheumatology: will we ever treat smarter, instead of just harder? Frontiers in Medice (Lausanne) 6:144.

Romão VC, Polido-Pereira J, Barros R, Luís R, Vidal B, Vieira-Sousa E, Vitorino E, Humby F, Kelly S, Pitzalis C, Saraiva F, Fonseca JE (2019). Efficacy, safety and sample quality of ultrasound-guided synovial needle biopsy in clinical practice and research: a prospective observational study. Arthritis Care & Research (Hoboken).

Sánchez-Maldonado JM, Cáliz R, Canet L, Horst RT, Bakker O, den Broeder AA, Martínez-Bueno M, Canhão H, Rodríguez-Ramos A, Lupiañez CB, Soto-Pino MJ, García A, Pérez-Pampin E, González-Utrilla A, Escudero A, Segura-Catena J, Netea-Maier RT, Ferrer MÁ, Collantes-Estevez E, López Nevot MÁ, Li Y, Jurado M, Fonseca JE, Netea MG, Coenen MJH, Sainz J (2019). Steroid Hormone-Related Polymorphisms Associate with the Development of Bone Erosions in Rheumatoid Arthritis and Help to Predict Disease Progression: Results from the Repair Consortium. Scientific Reports 9(1):14812.

Sanmarti R, Veale DJ, Martin-Mola E, Escudero-Contreras A, González C, Ercole L, Alonso R, Fonseca JE, ToSpace Study group (2019). Reducing or maintaining the dose of subcutaneous tocilizumab in patients with rheumatoid arthritis in clinical remission: a randomized, open-label trial. Arthritis Rheumatology.

Santos-Faria D, Tavares-Costa J, Eusébio M, Leite Silva J, Ramos Rodrigues J, Sousa Neves J, Duarte AC, Lopes C, Valido A, Dinis J, Freitas J, Santiago M, Ferreira R, Ganhão S, Miranda L, Peixoto D, Teixeira F, Alcino S, Afonso C, Santos MJ (2019). Tocilizumab and rituximab have similar effectiveness and are both superior to a second tumour necrosis factor inhibitor in rheumatoid arthritis patients who discontinued a first TNF inhibitor. Acta Reumatológica Portuguesa 44(2):103-113.

Teixeira V, Barreira S, Valido A, Macieira C, Fonseca JE (2019). Outcomes of rheumatic patients referred from Portuguese speaking African countries for medical evaluation in Portugal. Acta Reumatológica Portuguesa 44(3):280-281.

Teixeira V, Mohammad AJ, Jones RB, Smith R, Jayne D (2019). Efficacy and safety of rituximab in the treatment of eosinophilic granulomatosis with polyangiitis. RMD Open 5(1):e000905.

Valido A, Cordeiro I (2019). Calcinosis in Systemic Sclerosis. The New England Journal of Medicine 381(17):1663.

Valido A, Crespo CL, Pimentel SF (2019). Muscle evaluation in axial spondyloarthritis – The evidence for Sarcopenia. Frontiers in Medicine 6:219.

Valido A, Silva-Dinis J, Saavedra MJ, Iria I, Gonçalves J, Lopes JP, Fonseca JE. Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center. Acta Reumatológica Portuguesa.

Vieira-Sousa E, Eusébio M, Ávila-Ribeiro P, Khmelinskii N, Cruz-Machado R, Martins Rocha T, Bernardes M, Santos-Faria D, Leite Silva J, Santos H, Miguel C, Carvalho P, Costa T, Duarte AC, Meirinhos T, Nero P, Fonseca JE, Santos MJ (2019). Real-World Long-Term Effectiveness of Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis patients from the Rheumatic Diseases Portuguese Register. Journal Rheumatology.


João Lacerda Lab

Campos CF, Leite L, Pereira P, Vaz CP; Branca R, Campilho F, Freitas F, Ligeiro D, Marques A, Torrado E, Silvestre R, Lacerda JF, Campos A, Cunha C, Carvalho A (2019). PTX3 Polymorphisms Influence Cytomegalovirus Reactivation After Stem-Cell Transplantation. Frontiers in Immunology 31(10):88.

Soares MV, Azevedo RI, Ferreira IA, Bucar S, Ribeiro AC, Vieira A, Pereira PNG, Ribeiro RM, Ligeiro D, Alho AC, Soares AS, Camacho N, Martins C, Lourenço F, Moreno R, Ritz J, Lacerda JF (2019). Naive and Stem Cell Memory T Cell Subset Recovery Reveals Opposing Reconstitution Patterns in CD4 and CD8 T Cells in Chronic Graft vs Host Disease. Frontiers in Immunology 6(10):334.


Joaquim Ferreira Lab

Alix JJP, Neuwirth C, Gelder L, Burkhardt C, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T, Moglia C, Omer T, Schrooten M, Nandedkar S, Stalberg E, Barkhaus PE, Furtula J, van Dijk JP, Baldinger R, Costa J, Otto M, Sandberg A, Weber M (2019). Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings. Clinical Neurophysiology 130(5):666-674.

Alves M, Caldeira D, Ferro JM Ferreira JJ (2019). Does Parkinson's disease increase the risk of cardiovascular events? A systematic review and meta-analysis. European Journal of Neurology 27(2):288-296. Review.

Anderson DG, Ferreira-Correia A, Rodrigues FB, Aziz NA, Carr J, Wild EJ, Margolis RL, Krause A (2019). Comparison of the Huntington's Disease like 2 and Huntington's Disease Clinical Phenotypes. Movement Disorders Clinical Practice 6(4):302-311.

Bachoud-Levi AC, Ferreira JJ, Massart R, Youssov K,  Rosser A, Busse M, Craufurd D, Reilmann R, De Michele G, Rae D, Squitieri F, Seppi K, Perrine C, Scherer-Gagou C, Audrey O, Verny C, Burgunder JM (2019). International Guidelines for the Treatment of Huntington's Disease, Frontiers in Neurology 10:710.

Boaventura I, Costa J, Fernandes RM, Ferreira JJ (2019). Perception and attitudes about rational prescription during medical training: results of focus groups including medical students and residents. Acta Médica Portuguesa 32(9):593-599.

Borges J, Rosa MV, Fernandes RM, Nogueira PJ, Bandeira T (2019). Hospital admissions in children with acute respiratory disease in Portugal. Pulmonology 25(2):122-125.

Borges M, Afonso-Silva M, Laires PA, Gouveia M, Alarcão J, Ascenção R, Costa J (2019). Cost-effectiveness of sacubitril/valsartan for the treatment of patients with heart failure with reduced ejection fraction in Portugal, Expert Review of Pharmacoeconomics & Outcomes Research 20:1-7.

Bouça‐Machado R, Duarte GS, Patriarca M, Castro Caldas A, Alarcão J, Fernandes RM, Mestre TA, Matias R, Ferreira JJ (2019). Measurement Instruments to Assess Functional Mobility in Parkinson's Disease: A Systematic Review. Movement Disorders Clinical Practice 7(2):129-139.

Bouca-Machado R, Rosário A, Caldeira D, Caldas AC, Guerreiro D, Venturelli M, Tinazzi M, Schena F, Ferreira JJ (2019). Physical Activity, Exercise, and Physiotherapy in Parkinson's Disease: Defining the Concepts. Movement Disorders Clinical Practice 7(1):7-15.

Braisch U, Muche R, Rothenbacher D, Landwehrmeyer GB, Long JD, Orth M, Bachoud-Levi AC, Bentivoglio AR, Biunno I, Bonelli RM, Burgunder JM, Dunnett SB, Ferreira JJ, Handley OJ, Heiberg A, Illmann T, REGISTRY Investigators European Hu (2019). Identification of symbol digit modality test score extremes in Huntington's disease. American journal of Medical Genetics Part B-Neuropsychiatric Genetics 180(3):232-245.

Brinkman D, Tichelaar J, Mokkink W, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz E, Maxwell S, Richir M, van Agtmael M (2019). Key learning outcomes for clinical pharmacology and therapeutics education in Europe: a modified delphi study. European Journal of Clinical Pharmacology 75:S57-S57.

Caldeira D, Alves M, David C, Costa J, Ferreira JJ, Pinto FJ (2019). Aspirin in the primary prevention of cardiovascular disease on diabetic patients: Systematic review and meta-analysis. Primary Care Diabetes.

Caldeira D, Marques A, Almeida J, Rodrigues T, Alves M, David C, Pinto FJ (2019). Recommendations and levels of evidence in the guidelines of the European Society of Cardiology: current scenario and time trends. European Heart Journal-Cardiovascular Pharmacotherapy pvz060.

Caldeira D, Nunes-Ferreira A, Rodrigues R, Vicente E, Pinto FJ, Ferreira JJ (2019). Non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation: A systematic review with meta-analysis and trial sequential analysis. Archives of Gerontology and Geriatrics 83:338-338.

Caldeira D, Rodrigues B, David C, Costa J, Pinto FJ, Ferreira JJ (2019). The association of influenza infection and vaccine with myocardial infarction: systematic review and meta-analysis of self-controlled case series. Expert Review of Vaccines 18(11):1211-1217.

Caldeira D, Alves D, Costa J, Ferreira JJ, Pinto FJ (2019). Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis. PLoS One 14(2):e0211228.

Cláudia MS, Travessa A, Bouça-Machado R, Caldeira D, Ferreira JJ (2019). Reporting and methodological quality of clinical trials on exercise therapy for Parkinson's disease, Parkinsonism & Related Disorders 69:150-156.

Constant C, Cosme J, Fernandes RM, Fonte P, Fonseca JA, Alves C, Bandeira T (2019). Practice of spirometry among physicians caring for children with asthma in Portugal - The EspiroPed survey. Pulmonology 26(1):54-56.

Domingos J, Radder D, Riggare S, Godinho C, Dean J, Graziano M, de Vries NM, Ferreira JJ, Bloem BR (2019). Implementation of a Community-Based Exercise Program for Parkinson Patients: Using Boxing as an Example. Journal of Parkinson's Disease 9(3):615-623.

Duarte GS, Alves M, Silva MA, Câmara R, Caldeira D, Ferreira JJ (2019). Cardiovascular events reported in Randomized Controlled Trials in Restless legs syndrome. Sleep Medicine 65:13-17.

Duarte GS, Nunes-Ferreira A, Rodrigues FB, Pinto FJ, Ferreira JJ, Costa J, Caldeira D (2019).  Morphine in acute coronary syndrome: systematic review and meta-analysis. BMJ OPEN 9(3):e025232.

Fabbri M, Coelho M, Abreu D, Guedes LC, Rosa MM, Godinho C, Cardoso R, Guimarães I, Antonini A, Zibetti M, Lopiano L, Ferreira, JJ (2019). Dysphagia predicts poor outcome in late-stage Parkinson's disease. Parkinsonism & Related Disorders 64:73-81.

Fabbri M, Pongmala C, Artusi CA, Romagnolo A, Rizzone MG, Zibetti M, Lopiano L (2019). Long-term effect of levodopa-carbidopa intestinal-gel on axial signs in Parkinson’s disease, Acta Neurologica Scandinavica 140(2):157-161.

Fabbri M, Zibetti M, Ferrero G, Accornero A, Guimarães I, Rizzone MG, Romagnolo A, Ferreira JJ, Lopiano L (2019). Is lowering stimulation frequency a feasible option for subthalamic deep brain stimulation in Parkinson's disease patients with dysarthria? Parkinsonism & Related Disorders 64:242-248.

Fabbri M, Zibetti M, Beccaria L, Merola A, Romagnolo A, Montanaro E, Ferreira JJ, Palermo, S, Lopiano L (2019).  Levodopa/carbidopa intestinal gel infusion and weight loss in Parkinson's disease. European Journal of Neurology 26(3):490-496.

Faustino PR, Duarte GS, Chendo I, Castro Caldas A, Reimão S, Fernandes RM, Vale J, Tinazzi M, Bhatia K, Ferreira JJ (2019). Risk of Developing Parkinson Disease in Bipolar Disorder: A Systematic Review and Meta-analysis. JAMA Neurology 77(2)192-198.

Fernandes RM, Wingert A, Vandermeer B, Featherstone R, Ali S, Plint AC, Stang AS, Rowe BH, Johnson DW, Allain D, Klassen TP, Hartling L (2019). Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis. BMJ Open 9(8):e028511.

Ferreira JJ, Lees A, Rocha J, Poewe W, Rascol O, Soares-da-Silva P (2019). Long-term efficacy of opicapone in fluctuating Parkinson's disease patients: a pooled analysis of data from two phase 3 clinical trials and their open-label extensions. European Journal of Neurology 26(7):953-960.

Ferreira JJ, Mestre TA, Lyons K, Benito-Leon J, Tan EK, Abbruzzese G, Hallett M, Haubenberger D, Elble R, Deuschl G, Autor(es) grupo: MDS Task Force Tremor; MDS Evidence Based Med Comm. (2019). MDS evidence-based review of treatments for essential tremor. Movement Disorders 34(7):950-958.

Freixo C, Ferreira V, Martins J, Almeida R, Caldeira D, Rosa M, Ferreira JJ (2019). Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review. Journal of Vascular Surgery 71(1):318-327.

Gates A, Caldwell P, Curtis S, Dans L, Fernandes RM, Hartling L, Kelly LE, Vandermeer B, Williams K, Woolfall K, Dyson MP (2019). Reporting of data monitoring committees and adverse events in paediatric trials: a descriptive analysis. BMJ Paediatrics Open 3(1):e000426.

Gorayeb RP, Forjaz MJ, Ferreira AG, Duarte GNS, Machado T, Ferreira JJ (2019). Electronic search strategies fail to identify randomized controlled trials (RCTs) in neurosurgery. Clinical Neurology and Neurosurgery 184:105446.

Gouveia M, Jesus G, Inês M, Costa J, Borges M (2019). Cost-effectiveness of the 13-valent pneumococcal conjugate vaccine in adults in Portugal versus "no vaccination" and versus vaccination with the 23-valent pneumococcal polysaccharide vaccine, Human Vaccines & Immunotherapeutics 15(4):850-858.

Gouveia M, Ascenção R, Fiorentino F, Costa J, Caldeira D, Broeiro-Gonçalves P, Fonseca C, Borges M (2019). The current and future burden of heart failure in Portugal. ESC Heart Failure 6(2):254-261.

Guedes LC, Mestre T, Outeiro TF, Ferreira JJ (2019). Are genetic and idiopathic forms of Parkinson's disease the same disease? Journal of Neurochemistry 152(5):515-522.

Haberkamp M, Moseley J, Athanasiou D, de Andres-Trelles F, Elferink A, Rosa MM, Magrelli A (2019). European regulators' views on a wearable-derived performance measurement of ambulation for Duchenne muscular dystrophy regulatory trials, Neuromuscular Disorders 29(7):514-516.

Horton MC, Nopoulos P, Nance M, Landwehrmyer GB, Barker RA, Squitieri F, Burgunder JM, Quarrell O, Bachoud-Levi AC, Bentivoglio AR, REGISTRY Investigators European. (2019). Assessment of the Performance of a Modified Motor Scale as Applied to Juvenile Onset Huntington's Disease, Journal of Huntingtons Disease 8(2):181-193.

Jácome C, Almeida R, Pereira AM, Araújo L, Correia M, Pereira M, Couto M, Lopes C, Chaves Loureiro C, Catarata MJ, Santos LM, Ramos B, Mendes A, Pedro E, Cidrais Rodrigues JC, Oliveira G, Aguiar AP, Arrobas AM, Costa J, Dias J, Todo Bom A, Azevedo J, Ribeiro C, Alves M, Leiria Pinto P, Neuparth N, Palhinha A, Gaspar Marques J, Martins P, Trincão D, Neves A, Todo Bom F, Alvarenga Santos M, Branco J, Lozoya C, Costa A, Silva Neto A, Silva D, Vasconcelos MJ, Teixeira MF, Ferreira-Magalhães M, Taborda Barata L, Carvalhal C, Santos N, Pinto CS, Rodrigues Alves R, Moreira AS, Morais Silva P, Fernandes R, Ferreira R, Alves C, Câmara R, Ferraz de Oliveira J, Bordalo D, Calix MJ, Marques A, Nunes C, Menezes F, Gomes R, Almeida Fonseca J, group, I. (2019). Asthma apps use and interest among patients with asthma: a multicentre study. Journal of Investigational Allergology and Clinical Immunology.

Jácome C, Pereira AM, Almeida R, Ferreira-Magalhaes M, Couto M, Araujo L, Pereira M, Correia MA, Loureiro CC, Catarata MJ, Maia Santos L, Pereira J, Ramos B, Lopes C, Mendes A, Cidrais Rodrigues JC, Oliveira G, Aguiar AP, Afonso I, Carvalho J, Arrobas, A, Coutinho Costa J, Dias J, Todo Bom A, Azevedo J, Ribeiro C, Alves M, Leiria Pinto P, Neuparth N, Palhinha A, Gaspar Marques J, Pinto N, Martins P, Todo Bom F, Alvarenga Santos M, Gomes Costa A, Silva Neto A, Santalha M, Lozoya C, Santos N, Silva D, Vasconcelos MJ, Taborda-Barata L, Carvalhal C, Teixeira MF, Alves RR, Moreira AS, Sofia Pinto C, Morais Silva P, Alves C, Câmara R, Coelho D, Bordalo D, Fernandes RM, Ferreira, R., Menezes F, Gomes R, Calix MJ, Marques A, Cardoso J, Emiliano M, Gerardo R, Nunes C, Ferreira JA, Carvalho A, Freitas P, Correia R, Fonseca JA, group I. (2019). Patient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts. BMJ Open 9(11):e031732.

Jamal A, Finkelstein Y, Kuppermann N, Freedman SB, Florin TA, Babl FE, Dalziel SR, Zemek R, Plint AC, Steele DW, Schnadower D, Johnson DW, Stephens D, Kharbanda A, Roland D, Lyttle MD, Macias CG, Fernandes RM, Benito J, Schuh S, Autor(es) grupo: Pediat Emergency Res Networks. (2019). Pharmacotherapy in bronchiolitis at discharge from emergency departments within the Pediatric, emergency Research Networks: a retrospective analysis. Lancet Child & Adolescent Health 3(8):539-547.

Kirolos A, Manti S, Blacow R, Tse G, Wilson T, Lister M, Cunningham S, Campbell A, Nair H, Reeves RM, Fernandes RM, Campbell H, RESCEU Investigators (2019). A Systematic Review of Clinical Practice Guidelines for the Diagnosis and Management of Bronchiolitis. Journal of Infectious Diseases jiz240.

Leal I, Rodrigues FB, Sousa DC, Duarte GS, Romão VC, Marques-Neves C, Costa J, Fonseca JE (2019). Anti-T NF Drugs for Chronic Uveitis in Adults-A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Frontiers in Medicine 6:104.

Leal Rato M, Duarte GS, Ferreira JJ (2019). Proper or Improper Use of the Crossover Design in Clinical Trials in Chronic Sciatica? Jama Neurology 76(6):731. 

Leal Rato M; Rascol O; Ferreira JJ (2019). The “long and winding road” of the disease‐modifying effects of levodopa has not ended yet. Movement Disorders 35(3):397-399.

Lees A, Ferreira JJ, Rocha JF, Rascol O, Poewe W, Gama H, Soares-da-Silva P (2019). Safety Profile of Opicapone in the Management of Parkinson's Disease. Journal of Parkinson's Disease 9(4):733-740.

Machado T, Duarte GS, Gonçalves N, Ferreira JJ, Costa J (2019). A critique of the fragility index. Lancet Oncology 20(10):e553. 

Mestre TA (2019). Recent advances in the therapeutic development for Huntington disease, Parkinsonism & Related Disorders 59:125-130.

Mestre TA,  Eberly S, Tanner C, Grimes D, Lang AE, Oakes D, Marras C (2019). Reply to "Studying reproducibility of data-driven Parkinson's disease subtypes, Parkinsonism & Related Disorders 66:245-246.

Miranda D, Breda J, Cardoso R, Gonçalves N, Caldas AC, Ferreira JJ (2019). Should the energy contribution of commercial thickeners be considered in the nutrition plan of patients with dysphagia? Nutrition in Clinical Practice.

Nenna R, Hunt KA, Dassios T, Collins JJP, Rottier RJ, Liu NM, Rottier B, Goutaki M, Karadag B, Prayle A, Fernandes RM, Parisi GF, Barben J, Rubbo B, Snijders D, Makrinioti H, Hall G, Pijnenburg MW, Grigg J (2019). Key paediatric messages from the 2018 European Respiratory Society International Congress. ERJ Open Research 5(2).

Neves MA, Bouça‐Machado R, Guerreiro D, Caniça V, Pona‐Ferreira F, Ferreira JJ (2019). Swimming Is Compromised in Parkinson's Disease Patients. Movement Disorders 35(2):365-369.

Oosterloo M, Bijlsma EK, van Kuijk SM, Minkels F, Die-Smulders CEM, EHDN REGISTRY Study Group (2019). Clinical and genetic characteristics of late-onset Huntington's disease. Parkinsonism & Related Disorders 61:101-105.

Pollock M, Fernandes RM, Newton AS, Scott SD, Hartling L (2019). A decision tool to help researchers make decisions about including systematic reviews in overviews of reviews of healthcare interventions. Systematic Reviews 8(1):29.

Pollock M, Fernandes RM, Newton AS, Scott SD, Hartling L (2019). The impact of different inclusion decisions on the comprehensiveness and complexity of overviews of reviews of healthcare interventions. Systematic Reviews 8(1):18.

Pollock M, Fernandes RM, Newton AS, Scott SD, Hartling L (2019). A decision tool to help researchers make decisions about including systematic reviews in overviews of reviews of healthcare interventions. Systematic Reviews 29(8).

Pollock M, Fernandes RM, Pieper D, Tricco AC, Gates M, Gates A, Hartling L (2019). Preferred Reporting Items for Overviews of Reviews (PRIOR): a protocol for development of a reporting guideline for overviews of reviews of healthcare interventions. Systematic Reviews 8(1):335.

Rato ML, Duarte GS, Ferreira AN, Alves M, Mainoli B, Teodoro T, Mestre TA, Costa J, Ferreira JJ (2019). Nocebo response in Parkinson's disease: A systematic review and meta-analysis. Parkinsonism & Related Disorders 65:13-19.

Rodrigues BS, David C, Costa J, Ferreira JJ, Pinto FJ, Caldeira D (2019). Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies. Heart 106(5):350-357.

Rodrigues FB, Byrne L, De Vita E, Johnson EB, Hobbs NZ, Thornton JS, Scahill RI, Wild EJ (2019). Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI. European Journal of Neuroscience 49(12):1632-1639.

Rodrigues FB, Duarte GS, Prescott D, Ferreira J, Costa J (2019). Deep brain stimulation for dystonia. Cochrane Database of Systematic Reviews 1:CD012405.

Rodrigues FB, Ferreira JJ, Wild EJ (2019). Huntington's Disease Clinical Trials Corner: June 2019, Journal of Huntington’s Disease 8(3):363-371.

Rodrigues FB, Quinn L, Wild EJ (2019). Huntington's Disease Clinical Trials Corner: January 2019. Journal of Huntington’s Disease 8(1):115-125.

Rosa PFS, Thomas SM, Balakirev FF, Bauer ED, Fernandes RM, Thompson JD, Ronning F, Jaime M (2019). Enhanced Hybridization Sets the Stage for Electronic Nematicity in CeRhIn5. Physical Review Letters 122(1):016402.

Simões R, Goncalves A, Ferreira JJ (2019). Is safinamide helpful in multiple system atrophy? Movement Disorders 34(SI):S2.

Stankovic I, Quinn N, Vignatelli L, Antonini A, Berg D, Coon E, Cortelli P, Fanciulli A, Ferreira JJ, Freeman R, Hoglinger GU, Iodice V, Kaufmann H, Klockgether T, Kostic V, Krismer F, Lang A, Levin J, Low P, Mathias C, Meissner WG, Kaufmann LN, Palma JA, Panicker JN, Pellecchia MT, Sakakibara R, Schmahmann J, Scholz SW, Singer W, Stamelou M, Tolosa E, Tsuji S, Seppi K, Poewe W,  Wenning GK, Gregor K, Autor(es) grupo: Movement Disorder Soc Multiple Sys (2019). A critique of the second consensus criteria for multiple system atrophy. Movement Disorders 34(7):975-984.


José Ferro Lab

Aguiar de Sousa D, Canhão P, Crassard I, Coutinho J, Arauz A, Conforto A, Béjot Y, Giroud M, Ferro JM, ISCVT-2-PREGNANCY Investigators (2017). Safety of Pregnancy After Cerebral Venous Thrombosis: Results of the ISCVT (International Study on Cerebral Vein and Dural Sinus Thrombosis)-2 Pregnancy Study. Stroke 48(11):3130-3133.

Diener HC, Sacco RL, Easton JD, Granger CB, Bernstein RA, Uchiyama S, Kreuzer J, Cronin L, Cotton D, Grauer C, Brueckmann M, Chernyatina M, Donnan G, Ferro JM, Grond M, Kallmünzer B, Krupinski J, Lee BC, Lemmens R, Masjuan J, Odinak M, Saver JL, Schellinger PD, Toni D, Toyoda K, RE-SPECT ESUS Steering Committee and Investigators (2019). Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source. The New England Journal of Medicine 380(20):1906-1917.

Ferro JM, Coutinho JM, Dentali F, Kobayashi A, Alasheev A, Canhão P, Karpov D, Nagel S, Posthuma L, Roriz JM, Caria J, Frässdorf M, Huisman H, Reilly P, Diener HC, RE-SPECT CVT Study Group (2019). Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis: A Randomized Clinical Trial. JAMA Neurology 76(12):1457-1465.

Ferro JM, Santos AC (2019). Emotions after stroke: A narrative update. International Journal of Stroke.

Marto JP, Kauppila LA, Jorge C, Calado S, Viana-Baptista M, Pinho-E-Melo T, Fonseca AC (2019). Intravenous Thrombolysis for Acute Ischemic Stroke After Recent Myocardial Infarction: Case Series and Systematic Review. Stroke 50(10):2813-2818.


Leonor Saúde Lab

Chapela D, Sousa S, Martins I, Cristóvão AM, Pinto P, Corte-Real S, Saúde L (2019). A zebrafish drug screening platform boosts the discovery of novel therapeutics for spinal cord injury in mammals. Scientific Reports 9(1):10475.


Luis Costa Lab

Alvim CM, Mansinho A, Paiva R, Brás R, Semedo PM, Martins SL, Ponte CB, Macedo D, Ribeiro L, Reis JP, Fernandes I, Costa L (2019). Prognostic factors for patients treated with abiraterone. Future Science 6(2): FSO436.

Dionísio MR, Mansinho A, Abreu C, Cavaco-Silva J, Casimiro S, Costa L (2019). Clinical and translational pharmacology of drugs for the prevention and treatment of bone metastases and cancer-induced bone loss. British Journal of Clinical Pharmacology 85(6):1114-1124.

Ferreira AR, Ribeiro J, Miranda A, Mayer A, Passos-Coelho JL, Brito M, Fernandes J, Gouveia J, Costa L, Vaz-Luis I (2019). Effectiveness of Adjuvant Ovarian Function Suppression in Premenopausal Women With Early Breast Cancer: A Multicenter Cohort Study. Clinical Breast Cancer 19(5):e654-e667.

Gano L, Pinheiro T, Matos AP, Tortosa F, Jorge TF, Gonçalves MS, Martins M, Morais TS, Valente A, Tomaz AI, Garcia MH, Marques F (2019). Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools. Anti-Cancer Agents in Medicinal Chemistry 19(10):1262-1275.

Garrido P, Fernandes I, Soares-Almeida L, Borges-Costa J (2019). Postirradition pseudosclerodermatous panniculitis mimicking a Kaposi sarcoma recurrence. International Journal of Dermatology 58(12):e249-e250.

Gil Marques F, Poli E, Malaquias J, Carvalho T, Portêlo A, Ramires A, Aldeia F, Ribeiro RM, Vitorino E, Diegues I, Costa L, Coutinho J, Pina F, Mareel M, Constantino Rosa Santos S (2019). Low doses of ionizing radiation activate endothelial cells and induce angiogenesis in peritumoral tissues. Radiotherapy and Oncology 141:256-261.

Lopes MB, Casimiro S, Vinga S (2019). Twiner: correlation-based regularization for identifying common cancer gene signatures. BMC Bioinformatics 20:356.

Loureiro H, Carrasquinha E, Alho I, Ferreira AR, Costa L, Carvalho AM, Vinga S (2019). Modelling cancer outcomes of bone metastatic patients: combining survival data with N-Telopeptide of type I collagen (NTX) dynamics through joint models. BMC Medical Informatics and Decision Making 19:13.

Macedo D, Garrido PM, Fernandes I, Santana A, Guerra J, Borges-Costa J (2019). Kaposi sarcoma in solid organ transplant recipients: a challenging case. Journal of the Portuguese Society of Dermatology and Venereology 77(3):257-260.

Magno L, Lessard CB, Martins M, Lang V, Cruz P, Asi Y, Katan M, Bilsland J, Lashley T, Chakrabarty P, Golde TE, Whiting PJ (2019). Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph. Alzheimer's Research & Therapy 11:16.

Mansinho A, Ferreira A, Casimiro S, Alho I, Vendrell I, Costa AL, Sousa R, Abreu C, Pulido C, Macedo D, Pacheco T, Correia L, Costa L (2019). Levels of circulating fibroblast growth factor 23 (FGF23) and prognosis in cancer patients with bone metastases. International Journal of Molecular Sciences 20(3):695.

Martins Cavaco AC, Eble JÁ (2019). A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies. Journal of Visualized Experiments 8(150):e60122.

Matos CP, Addisa Y, Nunes P, Barroso S, Alho I, Martins M, Matos APA, Marques F, Cavaco I, Pessoa JC, Correia I (2019). Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) complexes. Journal of Inorganic Biochemistry 198:110727.

Patel VM, Flanagan CE, Martins M, Jones CL, Butler RM, Woollard WJ, Bakr FS, Yoxall A, Begum N, Katan M, Whittaker SJ, Mitchell TJ (2019). Frequent and Persistent PLCG1 Mutations in Sézary Cells Directly Enhance PLCγ1 Activity and Stimulate NFκB, AP-1, and NFAT Signaling. Journal of Investigation in Dermatology 140(2):380-389.

Querido S, Fernandes I, Weigert A, Casimiro S, Albuquerque C, Ramos S, Adragão T, Luz I, Paixão P, Chasqueira M, Santos M, Machado D (2019). High-grade urothelial carcinoma in a kidney transplant recipient after JC virus nephropathy: the first evidence of JC virus as a potential oncovirus in bladder cancer. American Journal of Transplantation.

Rivas F, Medeiros A, Comini M, Suescun L, Rodríguez Arce E, Martins M, Pinheiro T, Marques F, Gambino D (2019). Pt-Fe ferrocenyl compounds with hydroxyquinoline ligands show selective cytotoxicity on highly proliferative cells. Journal of Inorganic Biochemistry 199:110779.

Santos AP, Vinagre J, Soares P, Claro I, Sanches A C, Gomes L, Fernandes I, Catarino AL, Preto J, Pereira BD, Marques AP, Rodrigues F, Amaral C, Rocha G, Mellidez JC, Simões H, Lopes JM, Bugalho MJ (2019). Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism. International Journal of Endocrinology 2019:4518742.

Sousa SA, Leitão JH, Silva RAL, Belo D, Santos IC, Guerreiro JF, Martins M, Fontinha D, Prudêncio M, Almeida M, Lorcy D, Marques F (2019). On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities. Journal of Inorganic Biochemistry 202:110904.

von Moos R, Costa L, Gonzalez-Suarez E, Terpos E, Niepel D, Body JJ (2019). Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody. Cancer Treatment Reviews 76:57-67. Review.

Willumsen N, Ali SM, Leitzel K, Drabick JJ, Yee N, Polimera HV, Nagabhairu V, Krecko L, Ali A, Maddukuri A, Moku P, Ali A, Poulose J, Menon H, Pancholy N, Costa L, Karsdal MA, Lipton A (2019). Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer. Scientific Reports 9(1):19761.


Luís Graça Lab

Alberca Custodio RW, Mirotti L, Gomes E, Nunes FPB, Vieira RS, Graca L, Almeida RR, Câmara NO, Russo M (2019). Dendritic Cells Expressing MyD88 Molecule Are Necessary and Sufficient for CpG-Mediated Inhibition of IgE Production In Vivo. Cells 8(10):1165.

Deng J, Wei Y, Fonseca VR, Graca L*, Yu D* (2019). T follicular helper cells and T follicular regulatory cells in rheumatic diseases. Nature Reviews Rheumatology 15:475-490.

Deng J, Wei Y, Fonseca VR, Graca L, Yu D (2019). T follicular helper cells and T follicular regulatory cells in rheumatic diseases. Nature Reviews Rheumatology 15(8):475-490.

Fonseca VR, Graca L (2019). Contribution of Foxp3+ Tfr cells for overall human blood CXCR5+ T lymphocytes. Clinical and Experimental Immunology 195(3):302-304.

Fonseca VR, Ribeiro F, Graca L (2019). Dissecting the Complexity of T Follicular Regulatory Cells. Immunological Reviews 288(1):112-127.

Fonseca VR, Ribeiro F, Graca L (2019). Dissecting the Complexity of T Follicular Regulatory Cells. Immunological Reviews 288:112-127.

Freitas RF, Basto AP, Almeida SCP, Santos RF, Gonçalves CM, Osorio JC, Carmo A, Leon K, Graca L (2019). Modulation of CD4 T cell function via CD6-targeting. EBioMedicine 47:427-435.

Rojas G, Carmenate T, Santo-Tomas JF, Valiente PA, Becker M, Perez-Riveron A, Tundidor Y, Ortiz Y, de Cossio-Diaz JF, Graca L, Dubel S, Leon K (2019). Directed evolution of super-secreted variants from phage-displayed human Interleukin-2. Scientific Reports 9:800.


Luísa Figueiredo Lab

Aresta-Branco F, Sanches-Vaz M, Bento F, Rodrigues JA, Figueiredo LM (2019). African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system. Proceedings of the National Academy of Sciences 116:20725-20735.

Carvalho T, Santos AM, Figueiredo LM (2019). Detection of Extravascular Trypanosoma Parasites by Fine Needle Aspiration. JoVe (150):1-11.

De Niz M, Meehan GR, Brancucci NMB, Marti M, Rotureau B, Figueiredo LM, Frischknecht F (2019). Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology 21(5):e13023.

Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M (2019). Trypanosoma brucei infection protects mice against malaria. PLoS Pathogens 15(11):e1008145.

Silva Pereira S, Trindade S, De Niz M, Figueiredo LM (2019). Tissue tropism in parasitic diseases. Open Biology 9(6):190036.


Luísa Lopes Lab

Carvalho K, Faivre E, Pietrowski MJ, Marques X, Gomez-Murcia V, Deleau A, Huin V, Hansen JN, Kozlov S, Danis C, Temido-Ferreira M, Coelho JE, Mériaux C, Eddarkaoui S, Gras SL, Dumoulin M, Cellai L; NeuroCEB Brain Bank, Landrieu I, Chern Y, Hamdane M, Buée L, Boutillier AL, Levi S, Halle A, Lopes LV, Blum D (2019). Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor. Brain 142(11):3636-3654.

Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H (2019). The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. Cell Reports 29(2):317-331.

Ribeiro M, Brigas HC, Temido-Ferreira M, Pousinha PA, Regen T, Santa C, Coelho JE, Marques-Morgado I, Valente CA, Omenetti S, Stockinger B, Waisman A, Manadas B, Lopes LV, Silva-Santos B, Ribot JC (2019). Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory. Science Immunology 4(40).

Temido-Ferreira M, Coelho JE, Pousinha PA, Lopes LV (2019). Novel Players in the Aging Synapse: Impact on Cognition. Journal of Caffeine and Adenosine Research 9(3):104-127.

Vaz RL, Chapela D, Coelho JE, Lopes LV, Ferreira JJ, Afonso ND, Sousa S, Outeiro TF. (2019). Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia. Neuroscience 424:58-71.


Mamede de Carvalho Lab

Alix JJP, Neuwirth C, Gelder L, Burkhardt C, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T, Moglia C, Omer T, Schrooten M, Nandedkar S, Stalberg E, Barkhaus PE, Furtula J, van Dijk JP, Baldinger R, Costa J, Otto M, Sandberg A, Weber W (2019). Assessment of the reliability of the motor unit size index (MUSIX) in multi-centre and single subject “round-robin” settings. Clinical Neurophysiology 130(5):666-674.

Brenner D, Rosenbohm A, Yilmaz R, Muller K, Grehl T, Petri S, Meyer T, Grosskreutz J, Weydt P, Ruf W, Neuwirth C, Weber M, Pinto P, Claeys KG, Schrank B, Jordan B, Knehr A, 1 Gunther K, Hubers A, Zeller D, Kubisch C, Jablonka S, Sendtner M, Klopstock T, de Carvalho M, Sperfeld A, Borck G, Volk AE, Dorst J, Weis J, Otto M, Schuster J, Tredici KD, Braak H, Danzer KM. Freischmidt A, Meitinger T, Strom TM, Ludolph AC, Andersen PM, Weishaupt JH, and German ALS network MND-NET* (2019). Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations (letter). Brain: A Journal of Neurology 142(12): 119-121.

Caetano A, Pereira M, de Carvalho, M (2019). A 15-minute session of direct current stimulation does not produce lasting changes in axonal excitability. Neurophysiologie Clinique 49(4):277-282.

Caetano A, Pereira P, Pereira M, de Carvalho M. Modulation of sensory nerve fiber excitability by transcutaneous cathodal direct current stimulation. Neurophysiologie Clinique 49(5):385-390.

Campos CF, de Carvalho M (2019). Distal myopathy and rapidly progressive dementia associated with a novel mutation in the VCP gene: expanding Inclusion Body Myopathy with early-onset Paget Disease and Frontotemporal Dementia spectrum. Journal of Clinical Neuroscience 64:8-10.

Campos CF, Viana P, Castro I, Castro J, de Carvalho M, Conceição I (2019). Non-invasive evaluation of sudomotor function in patients with Myasthenia Gravis. Neurophysiologie Clinique-Clinical Neurophysiology 49(1):81-86.

Cavanagh SE, Malalasekera WN, Miranda B, Hunt, LT, Kennerley SW (2019). Visual fixation patterns during economic choice reflect covert valuation processes that emerge with learning. Proceedings of the National Academy of Sciences of the United States of America 116(45): 22795-22801.

Coelho P, Santos MO (2019). First Portuguese patient presenting with hereditary sensory and autonomic neuropathy type 1E associated with a novel mutation in DNMT1 gene. Neurological Sciences.

Coelho T, Yarlas A, Waddington-Cruz M, White MK, Sikora Kessler A, Lovley A, Pollock M, Guthrie S, Ackermann EJ, Hughes SG, Karam C, Khella S, Gertz M, Merlini G, Obici L, Schmidt HH, Polydefkis M, Dyck PJB, Brannagan Iii TH, Conceição I, Benson MD, Berk JL (2019). Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis. Journal of Neurology.

Conceição I (2019). Novel RNA-targeted therapies for hereditary ATTR amyloidosis and their impact on the autonomic nervous system. Clinical Autonomic Research 29(Sup 1):11-17. Review.

Conceição I (2019). Response: Suhr OB: commentary to Isabel Conceição et al. early diagnosis through targeted follow-up of identified carriers of TTR gene mutations. Amyloid 26(4):248-249.

Conceição I, Coelho T, Rapezzi C, Parman Y, Obici L, Galán L, Rousseau A (2019). Assessment of patients with hereditary transthyretin amyloidosis - understanding the impact of management and disease progression. Amyloid 26(3):103-111.

Conceição I, Damy T, Romero M, Galán L, Attarian S, Luigetti M, Sadeh M, Sarafov S, Tournev I, Ueda M (2019). Early diagnosis of ATTR amyloidosis through targeted follow-up of identified carriers of TTR gene mutations. Amyloid 26(1):3-9.

Conceição I, de Castro I, Castro J (2019). Correlation between Sudoscan and COMPASS 31: assessment of autonomic dysfunction on hATTR V30M patients. Amyloid 26(Sup 1):23.

Costa J, Streich L, Pinto S, Pronto-Laborinho A, Nimtz M, Conradt HS, de Carvalho M (2019). Exploring cerebrospinal fluid IgG N-glycosylation as potential biomarker for Amyotrophic Lateral Sclerosis. Molecular Neurobiology 56(8):5729–5739.

Costa MR, Gromicho M, Pronto-Laborinho AC, Miltényi GM, de Carvalho M (2019). Novel TBK1 LoF variant in a family with upper motor neuron predominant motor neuron disease. Journal of the Neurological Sciences 403: 117-118.

de Campos CF, Conceição I, Castro I (2019). Early diagnostic tools in hereditary amyloidosis related to transthyretin (hATTR) V30M autonomic neuropathy. Amyloid 26(Sup1):35-36.

de Campos CF, Vidailhet M, Toutain A, de Becdelièvre A, Funalot B, Bonello‐Palot N, Stojkovic T (2019). Hereditary Sensory Autonomic Neuropathy Type II: report of two novel mutations in the FAM134B gene. Journal of the Peripheral Nervous System 24(4):354-358.

de Carvalho M (2019). Guide the EMG Lines. Clinical Neurophysiology 130(9):1682-1683. Editorial.

de Carvalho M, Pinto S, Swash, M (2019). Diaphragmatic Neurophysiology and Respiratory Markers in ALS. Frontiers in Neurology 10:143.

de Carvalho M, Swash M (2019). Motor unit recruitment in myopathy: The myopathic EMG reconsidered. Journal of Electromyography and Kinesiology 45:41-45.

de Carvalho M, Swash M (2019). The ‘split-leg’ syndrome in ALS: specific or variable? Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20(7-8): 615-616.

de Carvalho M, Turkman A, Swash M (2019). Sensory modulation of fasciculation discharge frequency. Muscle & Nerve 59(6):688-693.

Falcão de Campos C, Parreira S, Conceição I (2019). Misdiagnosis in late versus early onset hATTR amyloidosis patients: experience from a reference centre. Amyloid 26(Sup1):37-38.

Farhan SMK, Howrigan DP, Abbott LE, Klim JR, Topp SD, Byrnes AE, Churchhouse C, Phatnani H, Smith BN, Rampersaud E, Wu G, Wuu J, Shatunov A, Iacoangeli A, Al Khleifat A, Mordes DA, Ghosh S, ALSGENS Consortium, FALS Consortium, Project MinE Consortium, CReATe Consortium, Eggan K, Rademakers R, McCauley JL, Schüle R, Züchner S, Benatar M, Taylor JP, Nalls M, Gotkine M, Shaw PJ, Morrison KE, Al-Chalabi A, Traynor B, Shaw CE, Goldstein DB, Harms MB, Daly MJ, Neale BM (2019). Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature Neuroscience 22(12):1966-1974.

Fernandes SR, Pereira M, Salvador R, Miranda PC, de Carvalho, M (2019). Cervical Trans-Spinal Direct Current Stimulation: a modelling-experimental approach. Journal of Neuroengineering and Rehabilitation 16(1):123.

González-Duarte A, Berk JL, Quan D, Mauermann ML, Schmidt HH, Polydefkis M, Waddington-Cruz M, Ueda M, Conceição IM, Kristen AV, Coelho T (2019). Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis. Journal of Neurology 267(3):703-712.

Inês M, Coelho T, Conceição I, Landeiro F, de Carvalho M, Costa J (2019). Societal costs and burden of hereditary transthyretin amyloidosis polyneuropathy. Amyloid-Journal of Protein Folding Disorders.

Johnsen B, Pugdahl K, Fuglsang-Frederiksen A, Kollewe K, Paracka L, Dengler R, Camdessanché JP, Nix W, Liguori R, Schofield I, Maderna L, Czell D, Neuwirth C, Weber M, Drory VE, Abraham A, Swash M, de Carvalho M (2019). Diagnostic criteria for amyotrophic lateral sclerosis: a multicentre study of inter-rater variation and sensitivity. Clinical Neurophysiology 130(2):397-314.

Körner S, Kammeyer J, Zapf A, Kuzma-Kozakiewicz M, Piotrkiewicz M, Kuraszkiewicz B, Goszczyńska H, Gromicho M, Grosskreutz J, Andersen PM, de Carvalho M, Petri S (2019). Influence of environment and lifestyle on incidence and progress of Amyotrophic Lateral Sclerosis in a German ALS population. Aging and Disease 10(2):205-216.

Miltenberger-Miltenyi G, Conceição VA, Gromicho M, Pronto-Laborinho AC, Pinto S, de Carvalho M (2019). C9orf72 expansion is associated with accelerated decline of respiratory function and decreased survival in amyotrophic lateral sclerosis. Journal of Neurology Neurosurgery and Psychiatry 90(1):118-120.

Miranda B*, Martins AI*, Jorge AF, Nunes C, Lemos J, Sousa L (2019). Paroxysmal Adduction After Internuclear Ophtalmoplegia. Journal of Neuro-Ophthalmology.

Mora JS, Genge A, Chio A, Estol CJ, Chaverri D, Hernández M, Marín S, Mascias J, Rodriguez GE, Povedano M, Paipa A, Dominguez R, Gamez J, Salvado M, Lunetta C, Ballario C, Riva N, Mandrioli J, Moussy M, Kinet J-P, Auclair C, Dubreuil P, Arnold V, Mansfield CD, Hermine, C; on behalf of the AB10015 STUDY GROUP (2019). Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 1-10.

Oliveira Santos M, Coelho P, Roque R, Conceição I (2019). Very late-onset limb-girdle muscular dystrophy type 2D: A milder form with a normal muscle biopsy. Journal of Clinical Neurosciences.

Pinto S, de Carvalho M (2019). SVC is a marker of respiratory decline function, similar to FVC, in patients with ALS. Frontiers in Neurology 10:109.

Pinto S, Gromicho M, de Carvalho M (2019). Assessing Upper Limb Function with ALSFRS-R in amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20(5-6):445-448.

Pinto S, Gromicho M, Swash M, de Carvalho M (2019). Cervical Muscle Weakness Is a Marker of Respiratory Dysfunction in Amyotrophic Lateral Sclerosis. Journal of Neurology Neurosurgery Psychiatry 91(3):323-324.

Pronto-Laborinho A, Pinto S, Gromicho M, Pereira M, Swash M, de Carvalho M (2019). Interleukin-6 and Amyotrophic Lateral Sclerosis. Journal of the Neurological Sciences 398:50-53.

Rezak M, de Carvalho M (2019). Disease modification in neurodegenerative diseases: not quite there yet. Neurology 94(1):12-13. Editorial.

Santos MO, Jacobsen AB, Tankisi H (2019). Multiple Point Stimulation MUNE in ALS: Toward a Faster Modification. Journal of Clinical Neurophysiology 36(3):220-223.

Shefner JM, Cudkowicz ME, Hardiman O, Cockroft BM, Lee JH, Malik FI, Meng L, Rudnicki SA, Wolff AA, Andrews JA, & on behalf of the VITALITY-ALS STUDY GROUP (2019). A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:584–594.

Silva C, Rodrigues FB, Duarte, GS, Costa J, de Carvalho M (2019). Prognostic value of phrenic nerve conduction study in Amyotrophic Lateral Sclerosis: a systematic review and meta-analysis. Clinical Neurophysiology 131(1):106-113.

Swash M, Czesnik D, de Carvalho M (2019). Muscular cramp: causes and management. European Journal of Neurology 26(2):214-221.

Swash M, de Carvalho M (2019). Fasciculations: opening Pandora´s Box. Clinical Neurophysiology 131(1):239-240. Editorial.

Swash M, de Carvalho M (2019). Testing electrolyte supplementation for muscle cramp. Muscle & Nerve 60(5):499-500. Editorial.

Swash M, de Carvalho M (2019). The neurophysiological index predicts survival in amyotrophic lateral sclerosis. Clinical Neurophysiology 130(9):1684-1685. Editorial.

Tazelaar GH, Dekker AM, van Vugt JJ, van der Spek RA, Westeneng H-J, Kool LJ, Kenna KP, van Rheenen W, Pulit SL, McLaughlin RL, Sproviero W, Iacoangeli A, Hübers A, Brenner D, Morrison KE, Shaw PJ, Shaw CE, Panadés MP, Mora Pardina JS, Glass JD, Hardiman O, Al-Chalabi A, van Damme P, Robberecht W, Landers JE, Ludolph AC, Weishaupt JH, van den Berg LH, Veldink JH, van Es M.A, on behalf of the Project MinE ALS Sequencing Consortium (2019). Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort. Neurobiology of Aging 74:234e9-234e15.

van den Berg LH, Sorenson E, Gronseth G, Macklin EA, Andrews J, Baloh RH, Benatar M, Berry JD, Chio A, Corcia P, Genge A (2019). Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials. Neurology 92(14):e1610-e1623.

van der Spek R, van Rheenen W, Pulit SL, Kenna KP, van den Berg LH, Veldink JH, on behalf of the Project MinE ALS Sequencing Consortium (2019). The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20(5-6): 432-440.

Zapata-Zapata CH, Dáger EF, Aguirre-Acevedo DC, de Carvalho M, Solano J (2019). Prevalence, incidence and clinical-epidemiological characterization of amyotrophic lateral sclerosis in Antioquia – Colombia. Neuroepidemiology.


Marc Veldhoen Lab

Ariotti S, Veldhoen M (2019). Immunology: Skin T Cells Switch Identity to Protect and Heal. Current Biology 29(6):R220-R223. 

Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, et al. (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European Journal of Immunology 49(10):1457-1973. 

Konjar S, Veldhoen M (2019). Dynamic Metabolic State of Tissue Resident CD8 T Cells. Frontiers in Immunology 10:1683.

Zhang S, Al-Maghout T, Cao I, Pelzl L, Salker M, Veldhoen M, Cheng A, Lang F, Singh Y (2019). Gut bacterial metabolite Urolithin A (UA) mitigates Ca2+ entry in T cells by regulating miR-10a-5p. Frontiers in Immunology 10:1737. 


Maria Carmo-Fonseca Lab

Bousard A, Raposo AC, Żylicz JJ, Picard C, Pires VB, Qi Y, Gil C, Syx L, Chang HY, Heard E, da Rocha ST (2019). The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation. EMBO Reports 20(10):e48019. 

da Rocha ST, Gendrel AV (2019). The influence of DNA methylation on monoallelic expression. Essays in Biochemistry 63(6):663-676. Review.

Desterro J, Bak-Gordon P, Carmo-Fonseca M (2019). Targeting mRNA processing as an anticancer strategy. Nature Reviews Drug Discovery 19(2):112- Review. 

Prudêncio P, Rebelo K, Grosso AR, Martinho RG, Carmo-Fonseca M (2019). Analysis of mammalian native elongating transcript sequencing (mNET-seq) high-throughput data. Methods

Silva TP, Cotovio JP, Bekman E, Carmo-Fonseca M, Cabral JMS, Fernandes TG (2019). Design principles for pluripotent stem cell-derived organoid engineering. Stem Cells International 4508470. Review. 

Sousa AC, Silveira C, Janeiro A, Malveiro S, Oliveira AR, Felizardo M, Nogueira F, Teixeira E, Martins J, Carmo-Fonseca M (2019). Detection of rare and novel EGFR mutations in NSCLC patients: implications for treatment-decision. Lung Cancer 139:35-40. 

Sousa-Franco A, Rebelo K, da Rocha ST, Bernardes de Jesus B (2019). LncRNAs regulating stemness in aging. Aging Cell 18(1):e12870. Review. 

Żylicz JJ, Bousard A, Žumer K, Dossin F, Mohammad E., da Rocha ST, Schwalb B, Syx L, Dingli F, Loew D, Cramer P, Heard E (2019). The implication of early chromatin changes in X chromosome inactivation. Cell 176(1-2):182-197.


Maria Mota Lab

de Menezes MN, Salles ÉM, Vieira F, Amaral EP, Zuzarte-Luís V, Cassado A, Epiphanio S, Alvarez JM, Alves-Filho JC, Mota MM, D'Império-Lima MR (2019). IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria. Scientific Reports 9(1):7575.

Mota MM, Mello-Vieira J (2019). Parasitism: Anopheles Mosquitoes and Plasmodium Parasites Share Resources. Current Biology 29(13):R632-R634. 

Mukherjee D, Chora ÂF, Mota MM (2019). Microbiota, a Third Player in the Host-Plasmodium Affair. Trends in Parasitology 36(1):11-18. Review.

Ribot JC, Neres R, Zuzarte-Luís V, Gomes AQ, Mancio-Silva L, Mensurado S, Pinto-Neves D, Santos MM, Carvalho T, Landry JJM, Rolo EA, Malik A, Silva DV, Mota MM, Silva-Santos B, Pamplona A (2019). γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection. Proceedings of the National Academy of Sciences of the United States of America 116(20):9979-9988. 

Vera IM, Grilo Ruivo MT, Lemos Rocha LF, Marques S, Bhatia SN, Mota MM, Mancio-Silva L (2019). Targeting liver stage malaria with metformin. JCI Insight 4(24):e127441. 


Mário Ramirez Lab

Barkham T, Zadoks RN, Azmai MNA, Baker S, Bich VTN, Chalker V, Chau ML, Dance D, Deepak RN, van Doorn HR, Gutierrez RA, Holmes MA, Huong LNP, Koh TH, Martins E, Mehershahi K, Newton P, Ng LC, Phuoc NN, Sangwichian O, Sawatwong P, Surin U, Tan TY, Tang WY, Thuy NV, Turner P, Vongsouvath M, Zhang D, Whistler T, Chen SL (2019). One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia. PLoS Neglected Tropical Diseases 13(6):e0007421. 

Björnsdóttir ES, Martins ER, Erlendsdóttir H, Haraldsson G, Melo-Cristino J, Ramirez M, Kristinsson KG (2019). Group B Streptococcal Neonatal and Early Infancy Infections in Iceland, 1976-2015. Pediatric Infectious Disease Journal 38(6):620–624.

Caneiras C, Lito L, Mayoralas-Alises S, Díaz-Lobato S, Melo-Cristino J, Duarte A (2019). Virulence and resistance determinants of Klebsiella pneumoniae isolated from a Portuguese tertiary university hospital centre over a 31-year period. Enfermedades Infecciosas Y Microbiologia Clinica 37(6):387–393. 

Caneiras C, Lito L, Melo-Cristino J, Duarte A (2019). Community- and hospital-acquired Klebsiella pneumoniae urinary tract infections in Portugal: virulence and antibiotic resistance. Microorganisms 7(5):138.

Dias O, Saraiva J, Faria C, Ramirez M, Pinto F, Rocha I (2019). iDS372, a phenotypically reconciled model for the metabolism of Streptococcus pneumoniae Strain R6. Frontiers of Microbiology 10:1283. 

Duque-Valencia J, Forero-Muñoz NR, Díaz FJ, Martins E, Barato P, Ruiz-Saenz J (2019). Phylogenetic evidence of the intercontinental circulation of a Canine distemper virus lineage in the Americas. Scientific Reports 9:15747. 

Echániz-Aviles G, Guerreiro SI, Silva-Costa C, Mendes CI, Carriço JA, Carnalla-Barajas MN, Soto-Noguerón A, Velazquez-Meza ME, Melo-Cristino J, Luévanos-Velazquez A, Martínez-Medina L, Vázquez-Larios MDR, Ramirez M (2019). Streptococcus pneumoniae serotype 3 in Mexico (1994 to 2017): decrease of the unusual clonal complex 4909 lineage following PCV13 introduction. Journal of Clinical Microbiology 57(1):e01354-18. 

Espadinha D, Sobral RG, Mendes CI, Méric G, Sheppard SK, Carriço JA, de Lencastre H, Miragaia M (2019). Distinct phenotypic and genomic signatures underlie contrasting pathogenic potential of Staphylococcus epidermidis clonal lineages. Frontiers of Microbiology 10:1971. 

Fleres G, Couto N, Schuele L, Chlebowicz M A, Mendes C I, van der Sluis L W M, Rossen J W A, Friedrich A W, García-Cobos S (2019). Detection of a novel mcr-5.4 gene variant in hospital tap water by shotgun metagenomic sequencing. Journal of Antimicrobial Chemotherapy 75(2):3626–3628. 

Friães A, Melo-Cristino J, Ramirez M, Portuguese Group for the Study of Streptococcal Infections (2019). Changes in emm types and superantigen gene content of Streptococcus pyogenes causing invasive infections in Portugal. Scientific Reports 9:18051.

Hanscheid T (2019). A Simple Method to Test Microscope Objectives Using a Laser Pointer. Microscopy Today 27(5):32-34.

Hänscheid T, Grobusch MP (2019). Coenzyme Q10 and cerebral malaria in mice: Questionable interpretations, improbable usefulness in humans. Parasitology International 74:101969. 

Hanscheid T, Grobusch MP (2019). Could antibiotic treatment of traveller's diarrhoea even prolong elimination of pathogens? Travel Medicine and Infectious Disease 28:104. 

Hanscheid T, Schlagenhauf P, Grobusch MP (2019). Atovaquone/proguanil for malaria chemoprophylaxis - Could a difference in susceptibility during hepatic development explain the need to continue drug intake for 7 days post-exposure? Travel Medicine and Infectious Disease 21:101527. 

Huizenga E, van der Ende J, Zwinkels N, Jimissa A, van der Ende-Bouwman C, van Rooijen R, Kargbo B, Agnandji ST, Hanscheid T, Goorhuis A, Grobusch MP (2019). A Modified Case Definition to Facilitate Essential Hospital Care During Ebola Outbreaks. Clinical Infectious Diseases 68(10):1763-1768. 

Jesus TF, Ribeiro-Gonçalves B, Silva DN, Bortolaia V, Ramirez M, Carriço JA (2019). Plasmid ATLAS: plasmid visual analytics and identification in high-throughput sequencing data. Nucleic Acids Research 47:D188–D194.

Pinho MD, Foster G, Pomba C, Machado MP, Baily JL, Kuiken T, Melo-Cristino J, Ramirez M, Portuguese Group for the Study of Streptococcal Infections (2019). Streptococcus canis are a single population infecting multiple animal hosts despite the diversity of the universally present M-like protein SCM. Frontiers of Microbiology 10:631. 

Pinto M, González-Díaz A, Machado MP, Duarte S, Vieira L, Carriço JA, Marti S, Bajanca-Lavado MP, Gomes JP (2019). Insights into the population structure and pan-genome of Haemophilus influenzae. Infection Genetics and Evolution 67:126–135. 

Silva-Costa C, Brito MJ, Aguiar SI, Lopes JP, Ramirez M, Melo-Cristino J, Portuguese Group for the Study of Streptococcal Infections, Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society (2019). Dominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012-2015). Scientific Reports 9:6. 


Miguel Castanho Lab

de Andrade VM, Bardají E, Heras M, Ramu VG, Junqueira JC, dos Santos JD, Castanho MARB, Conceiçao K (2019). Antifungal and anti-biofilm activity of designed derivatives from kyotorphin. Fungal Biology.

Faustino AF, Barbosa GM, Silva M, Castanho MARB, Da Poian AT, Cabrita EJ, Santos NC, Almeida FCL, Martins IC (2019). Fast NMR method to probe solvent accessibility and disordered regions in proteins. Scientific Reports 9(1):1647.

Pérez-Peinado C, Dias SA, Mendonça DA, Castanho MARB, Veiga AS, Andreu D (2019). Structural determinants conferring unusual long life in human serum to rattlesnake-derived antimicrobial peptide Ctn[15-34]. Journal of Peptide Science 25(8):e3195.

Petrin THC, Fadel V, Martins DB, Dias SA, Cruz A, Sergio LM, Arcisio-Miranda M, Castanho MARB, Dos Santos Cabrera MP (2019). Synthesis and Characterization of Peptide-Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity. Biomacromolecules 20(7):2743-2753.

Philippe GJ, Gaspar D, Sheng C, Huang YH, Benfield AH, Condon ND, Weidmann J, Lawrence N, Löwer A, Castanho MARB, Craik DJ, Troeira Henriques S (2019). Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. ACS Chemical Biology 14(9):2071-2087.

Pinto SN, Dias SA, Cruz AF, Mil-Homens D, Fernandes F, Valle J, Andreu D, Prieto M, Castanho MARB, Coutinho A, Veiga AS (2019). The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms. Journal of Antimicrobial Chemotherapy 74(9):2617-2625.

Santa-Maria AR, Walter FR, Valkai S, Brás AR, Mészáros M, Kincses A, Klepe A, Gaspar D, Castanho MARB, Zimányi L, Dér A, Deli MA (2019). Lidocaine turns the surface charge of biological membranes more positive and changes the permeability of blood-brain barrier culture models. Biochimica et Biophysica Acta - Biomembranes 1861(9):1579-1591. 

Skalska J, Oliveira FD, Figueira TN, Mello ÉO, Gomes VM, McNaughton-Smith G, Castanho MARB, Gaspar D (2019). Plant defensin PvD1 modulates the membrane composition of breast tumour-derived exosomes. Nanoscale 11(48):23366-23381.

Sousa DC, Leal I, Moreira S, do Vale S, Silva-Herdade AS, Aguiar P, Dionísio P, Abegão Pinto L, Castanho MARB, Marques-Neves C (2019). A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography. Frontiers in Neuroscience 13:566.

Vernen F, Harvey PJ, Dias SA, Veiga AS, Huang YH, Craik DJ, Lawrence N, Troeira Henriques S (2019). Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. International Journal of Molecular Sciences 20(17): 4184. 


Miguel Prudêncio Lab

Aguiar L, Machado M, Sanches-Vaz M, Prudêncio M, Vale N, Gomes P (2019). Coupling the cell-penetrating peptides Transportan and Transportan 10 to primaquine enhances its activity against liver-stage malaria parasites. MedChemComm 10(2):221-226.

Arez F, Rebelo S, Fontinha D, Simão D, Martins TR, Machado M, Fischli C, Oeuvray C, Badolo L, Carrondo MJT, Rottmann M, Spangenberg T, Brito C, Greco B*, Prudêncio M*, Alves PM* (2019). Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting Plasmodium hepatic infection. ACS Infectious Diseases 5(11):1831-1842.

Azevedo R, Mendes AM, Prudêncio M (2019). Inhibition of Plasmodium sporogonic stages by ivermectin and other avermectins. Parasites & Vectors. 12(1):594.

Beus M, Fontinha D, Held J, Rajić Z, Prudêncio M, Zorc B (2019). Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides. Acta Pharmaceutica 69(2):233-248. 

Beus M, Fontinha D, Held J, Rajić Z, Uzelac L, Kralj M, Prudêncio M, Zorc B (2019). Primaquine and chloroquine fumardiamides as promising antiplasmodial agents. Molecules 24(15).

Kumar M, Olkmbo J, Mambwe D, Taylor D, Lawrence N, Reader J, Watt MV, Fontinha D, Sanches-Vaz M, Bezuidenhout B, Lauterbach S, Liebenberg D, Birkholtz LM, Coetzer TL, Prudêncio M, Egas TJ, Wittlin S, Chibale K (2019). Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action. ACS Infectious Diseases 5(2):303-315. 

Mayoka G, Njoroge M, Okombo J, Gibhard L, Sanches-Vaz M, Fontinha D, Birkholtz LM, Reader J, van der Watt M, Coetzer TL, Lauterbach S, Churchyard A, Bezuidenhout B, Egan TJ, Yeates CL, Wittlin S, Prudêncio M, Chibale K (2019). Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria. Journal of Medicinal Chemistry 62(2):1022-1035. 

Pavić K, Rubinić B, Rajić Z, Fontinha D, Prudêncio M, Uzelac L, Kralj M, Held J, Zorc B (2019). Primaquine homodimers as potential antiplasmodial and anticancer agents. Bioorganic & Medicinal Chemistry Letters 29(19).

Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M (2019). Trypanosoma brucei infection protects mice against malaria. PLoS Pathogens 15(11).

Wolanin K, Fontinha D, Sanches‐Vaz M, Nyboer B, Heiss K, Mueller AK, Prudêncio M (2019). A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle. Cellular Microbiology 21(10). 


Miguel Remondes Lab

Ferreira-Fernandes E, Quintino C, Remondes M* (2019). A Gradient of Hippocampal Inputs to the Medial Mesocortex. Cell Reports 29(10):3266-3279. 


Nuno Morais Lab

Baker C, Rodrigues T, de Almeida BP, Barbosa-Morais NL, Bernardes GJL (2019). Natural product-drug conjugates for modulation of TRPV1-expressing tumors. Bioorganic & Medicinal Chemistry 27(12):2531-2536.

de Almeida BP, Vieira AF, Paredes J, Bettencourt-Dias M, Barbosa-Morais NL (2019). Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome. PLoS Computational Biology 15(3):e1006832.

Godinho-Silva C, Domingues RG, Rendas M, Raposo B, Ribeiro H, da Silva JA, Vieira A, Costa RM, Barbosa-Morais NL, Carvalho T, Veiga-Fernandes H (2019). Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis. Nature 574(7777):254-258.

Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ (2019). Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer. eLife 8:e47678.

Rodrigues T, de Almeida BP, Barbosa-Morais NL, Bernardes GJL (2019). Dissecting celastrol with machine learning to unveil dark pharmacology. Chemical Communications 55(45):6369-6372.

Saraiva-Agostinho N, Barbosa-Morais NL (2019). psichomics: graphical application for alternative splicing quantification and analysis. Nuclei Acids Research 47(2):e7.


Nuno Santos Lab

Amaral VSG, Fernandes CM, Felício MR, Valle AS, Quintana PG, Almeida CC, Barreto-Bergter E, Gonçalves S, Santos NC, Kurtenbach E (2019). Psd2 pea defensin shows a preference for mimetic membrane rafts enriched with glucosylceramide and ergosterol. Biochimica et Biophysica Acta-Biomembranes 1861(4):713-728.

Barros E, Gonçalves RM, Cardoso MH, Santos NC, Franco OL, Cândido ES (2019). Snake venom cathelicidins as natural antimicrobial peptides. Frontiers in Pharmacology 10:1415.

Carvalho JR, Fortunato IC, Fonseca CG, Pezzarossa A, Barbacena P, Dominguez-Cejudo MA, Vasconcelos FF, Santos NC, Carvalho FA, Franco CA (2019). Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration. eLife 8:e45853.

Eaton P, Amaral CP, Couto SCP, Oliveira MS, Vasconcelos AG, Borges TKS, Kückelhaus SAS, Leite JRSA, Muniz-Junqueira MI (2019). Atomic Force Microscopy Is a Potent Technique to Study Eosinophil Activation. Frontiers in Physiology 10:1261.

Faustino AF, Barbosa GM, Silva M, Castanho MARB, Da Poian AT, Cabrita EJ, Santos NC, Almeida FCL, Martins IC (2019). Fast NMR method to probe solvent accessibility and disordered regions in proteins. Scientific Reports 9:1647.

Faustino AF, Martins AS, Karguth N, Artilheiro V, Enguita FJ, Ricardo JC, Santos NC, Martins IC (2019). Structural and functional properties of the capsid protein of Dengue and related Flavivirus. International Journal of Molecular Sciences 20(16):3870.

Fensterseifer ICM, Felício MR, Alves ESF, Cardoso MH, Torres MDT, Matos CO, Silva ON, Lu TK, Freire MV, Neves NC, Gonçalves S, Lião LM, Santos NC, Porto WF, Fuente-Nunez C, Franco OL (2019). Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria. Biochimica et Biophysica Acta-Biomembranes 1861(7):1375-1387.

Figueira TN, Domingues MM, Illien F, Cadima-Couto I, Todorovski T, Andreu D, Sagan S, Castanho MARB, Walrant A, Veiga AS (2019). Enfuvirtide-protoporphyrin IX dual-loaded liposomes: in vitro evidence of synergy against HIV-1 entry into cells. ACS Infectious Diseases 6(2):224-236.

Gomes B, Sanna G, Madeddu S, Hollmann A, Santos NC (2019). Combining 25-hydroxycholesterol with a HIV fusion inhibitor peptide: interaction with biomembrane model systems and human blood cells. ACS Infectious Diseases 5(4):582-591.

Guedes AF, Moreira C, Nogueira JB, Santos NC, Carvalho FA (2019). Fibrinogen-erythrocyte binding and hemorheology measurements on the assessment of essential arterial hypertension patients. Nanoscale 11(6):2757-2766.

Irazazabal LN, Porto WF, Fensterseifer ICM, Alves ESF, Matos CO, Menezes ACS, Felício MR, Gonçalves S, Santos NC, Ribeiro SM, Humblot V, Lião LM, Ladram A, Franco OL (2019). Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide. Biochimica et Biophysica Acta-Biomembranes 1861(1):178-190.

Maillard APVF, Gonçalves S, Santos NC, Mishima BAL, Dalmasso PR, Hollmann A (2019). Studies on interaction of green silver nanoparticles with whole bacteria by surface characterization techniques. Biochimica et Biophysica Acta-Biomembranes 1861(6):1086-1092.

Makowski M, Silva ÍC, Amaral CP, Gonçalves S, Santos NC (2019). Advances in lipid and metal nanoparticles for antimicrobial peptide delivery. Pharmaceutics 11(11):588.

Martinez M, Gonçalves S, Felício MR, Maturana P, Santos NC, Semorile L, Hollmann A, Maffía PC (2019). Synergistic and antibiofilm activity of the antimicrobial peptide P5 against carbapenem-resistant Pseudomonas. Biochimica et Biophysica Acta-Biomembranes 1861(7):1329-1337.

Martins AS, Carvalho FA, Faustino AF, Martins IC, Santos NC (2019). West Nile virus capsid protein interacts with biologically relevant host lipid systems. Frontiers in Cellular and Infection Microbiology 9:8.

Meneguetti BT, Cardoso MH, Ribeiro CFA, Felício MR, Pinto IB, Santos NC, Carvalho CME, Franco OL (2019). Neuropeptide receptors as potential pharmacological targets for obesity. Pharmacology & Therapeutics 196:59-78.


Paulo Filipe Lab

Aguiar-Ricardo I, Nunes-Ferreira A, Roda Â, Brás-Rosário L (2019). Omalizumab induced Takotsubo syndrome: case report. European Heart Journal: Case Reports 3:1-5.

Alpalhão M, Borges-Costa J, Filipe P (2019). Psoriasis in HIV infection: an update. International Journal of STD & AIDS 30(6): 596-604. Review.

Granulomatous Skin Diseases in a Tertiary Care Portuguese Hospital: A 10-year Retrospective Study. Queirós C, Uva L, Soares Almeida L, Filipe P (2019). American Journal of Dermatopathology (CME article).

Mendes R, Ortins-Pina A, Fraga A, Marques T, Viveiros M, Machado D, Soares-Almeida L, Freitas J, Filipe P (2019). Mycobacterium marinum lymphocutaneous infection. Dermatology Online Journal 25(2):10-16. 

Mendonça-Sanches M, Rolim I, Cabeçadas J, Rafael M (2019). An Unusual Presentation of Metastatic Breast Carcinoma. European Journal of Case Reports in Internal Medicine 6(4):001089. 

Oliveira A, Alpalhão M, Filipe P, Maia-Silva J (2019). The role of Janus kinase inhibitors in the treatment of alopecia areata: A systematic review. Dermatologic Therapy 32(5):1-9. 

Pimenta R, Borges-Costa J (2019). Successful Treatment with Fusidic Acid in a Patient with Folliculitis Decalvans. Acta Dermatovenerologica Croatica 27(1):49-50.

Pimenta R, Oliveira A (2019). Dermoscopic and confocal microscopic presentation of linear lichen planus. Skin Research and Technology 25(5):765-767. 

Queirós C, Filipe P, Soares-Almeida L (2019). Cutaneous Metastases from Solid Neoplasm in the 21st Century: A Retrospective Study from a Portuguese Tertiary Care Centre. Journal of the European Academy of Dermatology and Venereology

Queirós C, Uva L, Soares Almeida L, Filipe P (2019). Multiple eruptive dermatofibromas associated with early pregnancy: case report and literature review. Dermatology Online Journal 25(5):12.

Roda Â, Marcos-Pinto A, Pimenta R, Maia-Silva J (2019). Earlobe reconstruction with a superiorly based bilobed infra-auricular flap. Journal of Cutaneous and Aesthetic Surgery 12(3):201-202.

Roda Â, Travassos AR, Soares-de-Almeida, Kutzner H (2019). Lupus erythematosus mimicking mycosis fungoides: CD123+ plasmacytoid dendritic cells as a useful diagnostic clue. Journal of Cutaneous Pathology 46(2):167-170.

Sanches M, Rolim I, Costa-Rosa J, Caldas G, Moura C (2019). Eruptive junctional nevi appearing during Langerhans cell histiocytosis treatment. European Journal of Case Reports in Internal Medicine 6(6):001088.


Pedro Sousa-Víctor Lab

Korzelius J, Azami S, Ronnen-Oron T, Koch P, Baldauf M, Meier E, Rodriguez-Fernandez IA, Groth M, Sousa-Victor P, Jasper H (2019). The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine. Nature Communications 10(1):1-13.

Munoz-Canoves P**, Neves J, Sousa-Victor P** (2019). Understanding muscle regenerative decline with aging: new approaches to bring back youthfulness to aged stem cells. FEBS Journal 287(3):406416. Review.

Neves J**, Sousa-Victor P** (2019). Regulation of inflammation as an anti-aging intervention. FEBS Journal 287(2020):43–52. Perspective.

Sousa-Victor P*, Neves J*, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soife I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H (2019). MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nature Metabolism 1(2): 276–290.


Pedro Simas Lab

Lawler C, Simas JP, Stevenson PG (2019). Vaccine protection against murid herpesvirus-4 is maintained when the priming virus lacks known latency genes. Immunology and Cell Biology 98(1)67-68.


Sérgio de Almeida Lab

Da Rocha ST, Gendrel A-V (2019). The influence of DNA methylation on monoallelic expression. Essays in Biochemistry 63(6):663-676. Review.

Landsverk HB, Sandquist LE, Sridhara SC, Rødland G, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG. (2019). Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1. Nucleic Acids Research 47(4):1797-1813.

Matos MR, Posa I, Carvalho FS, Morais VA, Grosso AR, de Almeida SF* (2019). A systematic pan-cancer analysis of genetic heterogeneity reveals associations with epigenetic modifiers. Cancers 11(3):391.

Vítor AC, Sridhara SC, Sabino JC, Afonso AI, Grosso AR, Martin RM, de Almeida SF (2019). Single-molecule imaging of transcription at damaged chromatin. Science Advances 5(1):eaau1249.


Sérgio Dias Lab

Gomes CP, Nóbrega-Pereira S, Domingues-Silva B, Rebelo K, Alves-Vale C, Marinho SP, Carvalho T, Dias S, Bernardes de Jesus B (2019). An antisense transcript mediates MALAT1 response in human breast cancer. BMC Cancer 19(1):771.


Vanessa Morais Lab

Cardanho-Ramos C, Faria-Pereira A, Morais VA (2019). Orchestrating mitochondria in neurons: Cytoskeleton as the conductor. Cytoskeleton. Review.

de Matos MR, Posa I, Carvalho FS, Morais VA, Grosso AR, de Almeida SF (2019). A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers. Cancers 20(3):11.

Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019). PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proceedings of the National Acadamy of Sciences of the United States of America 116(1):277-286.