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The Histology and Comparative Pathology Laboratory aims to provide histology and comparative pathology support to iMM scientists investigating animal models of human disease, and scientists/physicians investigating human disease. Services are also available for extramural investigators.

What is comparative medicine and pathology?

Comparative medicine and pathology are divisions of experimental medicine and pathology concerned with understanding phenomena integral to diseases of all species, including humans. Investigation focuses on both the similarities and differences between species and includes the development, validation, and utilisation of animal models (both naturally occurring and experimentally induced) to study the aetiology, pathogenesis, and treatment of human and veterinary disease. The discipline also includes the study of the normal biology of animals used as laboratory models.

More Informations:

Histology Wiki


  • Processing, inclusion, sectioning and HE staining - paraffin; embedding and sectioning - cryostat;
  • Histochemistry/special stains.

  • Protocol optimisation;
  • Testing of antibodies on project tissue.

TEM - transmission electron microscopy
  • Technique consulting and protocol optimisation;
  • Sample processing for TEM and Immunolabeling;
  • Semi- and Ultra-thin sectioning and grid counterstain;
  • Visualisation and recording (equipment: Hitachi H-7650).

  • Gross and microscopic examination with written reports and images;
  • Assist in study design, Manuscript preparation & Grant submission.


For Prices consult our price table.

How to use the service

  1. Cryostat utilisation requires booking online. Users must request booking permission online (induction/training required);
  2. Online requisition (link bellow) should be properly filled and submitted prior to sample delivery;
  3. Researchers will be notified by e-mail as soon as the work is complete, and should collect the slides at the lab; when the work is for pathology assessment the slides will be immediately re-directed to the pathologist (be sure to include all details regarding experimental setting and expected outcome of the pathology assessment in the request form or contact the pathologist).

Requisition form


Acknowledgments or Authorship
Manuscripts and grants presenting work supported by our lab should include the following acknowledgement:
"This work was supported by the Histology and Comparative Pathology Laboratory of the Instituto de Medicina Molecular."
Be sure to also provide us a copy of published reports.

Authorship is not mandatory but inclusion of the pathologist or histotechnician may be beneficial for the purposes of manuscript preparation and peer-review. Please consider authorship for the pathologist or histotechnician when our staff is significantly involved in experimental design and sample preparation, in generating a major portion of results and analysis, and/or in manuscript preparation. We thank you in advance for acknowledging our efforts and contributing to the future success of our laboratory!


Senior Technician:
Ana Biscaia Santos

Ana Margarida Cristovão