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O Laboratório de Histologia e Patologia Comparada funciona como estrutura de apoio à investigação feita com recurso a modelos animais e de doença humana. Oferecemos desde o apoio técnico no planeamento experimental, ao processamento histológico de amostras biológicas, consultoria em patologia e microscopia electrónica. Estes serviços estão também disponíveis para investigadores externos.

O que são a medicina e patologia comparadas?

Medicina Comparada e Patologia Comparada são divisões da medicina experimental e patologia que visam compreender fenómenos comuns a doenças de todas as espécies, incluindo a humana. A investigação centra-se nas semelhanças e diferenças entre espécies e em como objectivo o desenvolvimento, validação e utilização de modelos animais (tanto tanto espontâneos como induzidos) no estudo da etiologia, patogénese e tratamento da doença humana e veterinária. A disciplina também inclui o estudo da biologia normal dos animais utilizados como modelos laboratoriais.

Mais Informações:

Histology Wiki (em inglês)

Formulário Requisições

Services


RESEARCH HISTOLOGY
  • Processing, inclusion, sectioning and HE staining - paraffin; embedding and sectioning - cryostat;
  • Histochemistry/special stains.

IMMUNOHISTOCHEMISTRY
  • Protocol optimisation;
  • Testing of antibodies on project tissue.

TEM - transmission electron microscopy
  • Technique consulting and protocol optimisation;
  • Sample processing for TEM and Immunolabeling;
  • Semi- and Ultra-thin sectioning and grid counterstain;
  • Visualisation and recording (equipment: Hitachi H-7650).

PATHOLOGIST SERVICES
  • Gross and microscopic examination with written reports and images;
  • Assist in study design, Manuscript preparation & Grant submission.

LASER CAPTION MICRODISECTION

For Prices consult our price table.

How to use the service

  1. Cryostat utilisation requires booking online. Users must request booking permission online (induction/training required);
  2. Online requisition (link bellow) should be properly filled and submitted prior to sample delivery;
  3. Researchers will be notified by e-mail as soon as the work is complete, and should collect the slides at the lab; when the work is for pathology assessment the slides will be immediately re-directed to the pathologist (be sure to include all details regarding experimental setting and expected outcome of the pathology assessment in the request form or contact the pathologist).

Requisition form

Publications

Acknowledgments or Authorship
Manuscripts and grants presenting work supported by our lab should include the following acknowledgement:
"This work was supported by the Histology and Comparative Pathology Laboratory of the Instituto de Medicina Molecular."
Be sure to also provide us a copy of published reports.

Authorship is not mandatory but inclusion of the pathologist or histotechnician may be beneficial for the purposes of manuscript preparation and peer-review. Please consider authorship for the pathologist or histotechnician when our staff is significantly involved in experimental design and sample preparation, in generating a major portion of results and analysis, and/or in manuscript preparation. We thank you in advance for acknowledging our efforts and contributing to the future success of our laboratory!

Equipa

Diretores de serviço:
Senior Technician:
Ana Margarida Cristovão
anampereira@medicina.ulisboa.pt

Ana Biscaia Santos
anabsantos@medicina.ulisboa.pt

Veterinarian: