Neurobiology of Ageing & Disease
Ageing, stress and neurodegenerative diseases are among the conditions that contribute to the accelerated loss of cognitive function. Our group's work is focused on understanding the mechanisms inducing this "early-ageing", which render the hippocampus - the brain area related to learning and memory – particularly susceptible.
We focus on characterizing the molecular mechanisms associated to hippocampal loss of function and its outcome in behavior performance and synaptic function, using rodent models. We ensure the translation to the human brain, by testing these molecular imprints in healthy and diseased human brain tissue. We are currently focused into exploring the role of adenosine A2A receptors as potential cognitive modulators both in vitro and in vivo.
Senior Postdoctoral Researcherjfecoelho@medicina.ulisboa.pt
Mariana de Brito Morais
Raquel Madruga da Costa
Senior Postdoctoral Researcherragomes@medicina.ulisboa.pt
- Molecular switches from aging towards neurodegeneration in the hippocampus
- Impact of circadian modulation on hippocampal-dependent memory
- Therapeutic actions of caffeine and caffeine analogs against memory deficits
- Cognitive dysfunction in Alzheimer's mouse models
- Molecular mechanisms of early cognitive deficits in Parkinson's disease
Ongoing Research Projects
FCT 2018-2021 Neuro-immune interactions - impact on cognitive functions in health and disease (with Julie Ribot)
FCT 2018-2021 The mechanisms of cognition (with Miguel Remondes)
FCT 2016-2019 Microglia dysregulation as trigger for chronic brain inflammation
FCT 2016-2019 Targeting the glycation defenses as a protective strategy for Parkinson’s disease
H2020 Twinning action SynaNet 2016-2019 “Neurologic and Psychiatric Disorders: from synapses to networks”
2019 Interstellar Initiative Award – NY Academy Sciences and Japan Agency AMED
2018 Santa Casa da Misericórida Mantero Belard Award
2018 CEEC FCT Principal Investigator Award
2017 Universidade de Lisboa/Caixa Geral de Depósitos Award (Menção Honrosa)
2013 Investigator FCT Award, Fundação para a Ciência e Tecnologia, Portugal
- Ribeiro M, Brigas HC, Temido-Ferreira M, et al. (2019) Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory. Sci Immunol. doi: 10.1126/sciimmunol.aay5199.
- Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H. (2019) The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. Cell Rep. doi: 10.1016/j.celrep.2019.08.103.
- Mariana Temido-Ferreira, Diana G. Ferreira, Vânia L. Batalha, Inês Marques-Morgado, Joana E. Coelho, Pedro Pereira, Rui Gomes, Andreia Pinto, Sara Carvalho, Paula M. Canas, Laetitia Cuvelier, Valerie Buée-Scherrer, Emilie Faivre, Younis Baqi, Christa E. Müller, José Pimentel, Serge N. Schiffmann, Luc Buée, Michael Bader, Tiago F. Outeiro, David Blum, Rodrigo A. Cunha, Hélène Marie, Paula A. Pousinha and Luísa V. Lopes (2018) Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors, Molecular Psychiatry 10.1038/s41380-018-0110-9.
- Diana G. Ferreira, Mariana Temido-Ferreira, Hugo Vicente Miranda, Vânia L. Batalha, Joana E. Coelho, Éva M. Szegö, Inês Marques-Morgado, Sandra H. Vaz, Jeong Seop Rhee, Matthias Schmitz, Inga Zerr, Luísa V. Lopes* and Tiago F. Outeiro* (2017) α-Synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B. Nature Neuroscience doi: 10.1038/nn.4648 *co-senior author.
- VL. Batalha, JM. Pego B Fontinha, AR Costenla, J Valadas, Y Baqi, H Radjainia, C E. Müller, AM. Sebastião and Luísa V. Lopes (2013) Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation. Mol. Psychiatry.