This site uses cookes. By using this site you are consenting to their use according to our Cookie policy.

i agree
back
Lymphocyte Regulation

The Cellular Immunology Lab studies mechanisms able to induce and maintain immune tolerance. We study diseases, or animal models of human pathologies, where the immune system has an inappropriate action, such as in autoimmunity, transplantation or allergy.

We aim to reprogram the immune system, inducing the expansion of regulatory T cells capable of reinstating the tolerance state. We always strive to validate our experimental results in collaboration with clinical scientists.

Research Team

Ana Catarina Mendes
Lab Manager
a.mendes@medicina.ulisboa.pt

Ana Isabel Matos
Trainee
aimatos@medicina.ulisboa.pt

Carina Peres
PhD Student
cperes@medicina.ulisboa.pt

Diogo Antunes
MSc Student
diogo.antunes@medicina.ulisboa.pt

ELESSA Dikélélé
MSc Student
dikelele.elessa@medicina.ulisboa.pt

Filipa Ribeiro
PhD Student
filipa.ribeiro@medicina.ulisboa.pt

José António Matos Silva
BSc Student
jose.antonio.silva@medicina.ulisboa.pt

João Malato
PhD Student
jmalato@medicina.ulisboa.pt

Pedro Ávila Ribeiro
PhD Student
pedro.ribeiro@medicina.ulisboa.pt

Rodrigo Pedroso
PhD Student
rpedroso@medicina.ulisboa.pt

Ruy M. Ribeiro
Senior Postdoctoral Researcher
ruyribeiro@medicina.ulisboa.pt

Sara Rosa
MSc Student
sara.rosa@medicina.ulisboa.pt

Saumya Kumar
PhD Student
saumya.kumar@medicina.ulisboa.pt

Valter R Fonseca
Postdoctoral Researcher
vfonseca@medicina.ulisboa.pt

Vanessa de Oliveira
Clinical Researcher
vgoliveira@medicina.ulisboa.pt

Research Areas

  • Tolerance
  • Regulatory T cells
  • Autoimmunity
  • Allergy
  • Transplantation
  • Monoclonal antibodies
  • Animal models

Ongoing Research Projects

2015/2019 Informatics and Genomics of Helper T cells (ENLIGHT-TEN-MSCA-ITN-2015-675395 - H2020)

Awards

  • Professor Jorge Silva Horta (second prize), 2019.
  • Carregosa Bank - Ordem dos Médicos (honorable mention), 2018.
  • iMM Innovators, TwinToInfect, 2017.
  • NEDAI Prize in Autoimmunity Research, 2011.
  • Young Entrepreneur Award 2010, from ANJE, 2010.
  • Honorary mention in the ISCTE-IUL MIT-Portugal Venture Competition, 2010.
  • BES National Innovation Award for Health Technologies, 2010.
  • Idea to Product (I2P) Global Competition 2009, 2nd place, University of Texas at Austin, 2009.
  • Prof. Heimburger Award in Coagulation Diseases, CSL Behring, 2009.

Selected Publications

  • Deng J, Wei Y, Fonseca VR, Graca L*, Yu D* (2019) “Follicular helper and follicular regulatory T cells in autoimmune rheumatic diseases: phenotype, pathogenesis and targeted immunotherapies”. Nature Rev Rheumatol. In press. (* joint senior/corresponding authors)
  • Fonseca VR, Romão VC, Agua-Doce A, Santos M, López-Presa D, Ferreiras AC, Fonseca JE, Graca L (2018) “The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome”. Arthritis Rheumatol. 70:774-784.
  • Fonseca VR, Agua-Doce A, Maceiras AR, Pierson W, Ribeiro F, Romão VC, Pires AR, Silva SL, Fonseca JE, Sousa AE, Linterman MA, Graca L (2017) Human blood CXCR5+Foxp3+ T cells are indicators of ongoing humoral activity not fully licensed with suppressive function. Science Immunol. 2, eaan1487.
  • Maceiras R, Almeida SCP, Mariotti-Ferrandiz E, Chaara W, Jebbawi F, Six A, Hori S, Klatzmann D, Faro J, Graca L (2017) T follicular helper and T follicular regulatory cells from the same germinal centers have different TCR-specificity. Nature Commun. 8:15067.
  • Monteiro M, Agua-Doce A, Almeida CF, Fonseca-Pereira D, Veiga-Fernandes H, Graca L (2015) IL-9 expression by invariante NKT cells is not imprinted during thymic development. J Immunol. 195: 3463-3471.
  • Oliveira VG, Agua-Doce A, Curotto de Lafaille M, Lafaille JJ, Graca L. (2013) Adjuvant facilitates anti-CD4 mediated immune tolerance to recombinant factor VIII in hemophilia through a Foxp3-independent mechanism that relies on IL-10. Blood 121: 3938-3945.
  • Monteiro M, Almeida CF, Agua-Doce A, Graca L. (2013) Induced IL-17-producing invariant Natural Killer T cells require activation in presence of TGF-β. J Immunol 190: 805-811.
  • Duarte J, Carrié N, Oliveira VG, Almeida C, Agua-Doce A, Rodrigues L, Simas P, Mars LT, Graca L. (2012) T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4-blockade in experimental autoimmune encephalomyelitis. J Immunol 189: 1680-1688.
  • Wollenberg I, Agua-Doce A, Hernández A, Almeida C, Oliveira V, Faro J, Graca L. (2011) Regulation of germinal centre reaction by Foxp3+ follicular regulatory T cells. J Immunol 187: 4553-4560. (380 citations – report on the discovery of Tfr cells)
  • Oliveira VG, Paiva R, Demengeot J, Graca L. (2011) Sub-optimal CD4 T cell activation triggers TGF-β-dependent conversion to Foxp3+ regulatory T cells Eur J Immunol 41:1249-55.
group leader :
Luís Graça