João Eurico Fonseca Lab

Rheumatology Research

The Rheumatology Research Lab results from a partnership between the iMM/FML and the Rheumatology Department of the Santa Maria Hospital. Basic scientists and clinicians closely work together to promote translational research and clinical excellence in the field of Rheumatology.

Our specific research objectives are the study of the impact of inflammatory joint diseases (such as Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA), Spondyloarthritis (SpA) and Systemic Lupus Erythematosus (SLE)) in order to characterize potential tools for early diagnosis and prognosis and to preview response to treatment interventions, taking a step forward towards precision medicine in the field of rheumatology.

Finally, we are involved in clinical trials, development of registries (in collaboration with the Portuguese Society of Rheumatology) and epidemiological studies, in providing services to the community, including expertise advisory to governmental institutions and in postgraduate teaching. The long-term objective of the RRU is to achieve recognition as an European League Against Rheumatism Centre of Excellence in Rheumatology.

Research Team

Research Areas

Early Arthritis.

Rheumatoid Arthritis; Spondylarthritis, Lupus, Pediatric Rheumatology:

• Biomarkers;
• Prognosis;
• Response to Treatment;
• Precision Medicine;
• New Targets.

Epidemiology of Rheumatic Diseases, Cohorts, Registries and Databases.

Recommendations and Guidelines.

Clinical Trials.

Ongoing Research Projects

2020/2022 Juvenile Idiopathic Arthritis. Coordinator: João Eurico da Fonseca. Funding Agency: PRES/EMERGE/EMUNET.

2020/2023 LESS – Lisbon Enthesitis Sonographic Score. Coordinator: João Eurico da Fonseca. Funding Agency: Novartis.

2020/2023 Clinical course and predictors of severe coronavirus disease 19 among patients with rheumatic diseases in Portugal – a multicentre, observational, nationwide study. Coordinator: João Eurico da Fonseca. Funding Agency: Merck Sharp & Dohme.

2020/2023 Comparative effectiveness of tofacitinib and interleukin (IL)23/IL17 inhibitors in PsA patients registered in the Rheumatic Diseases Portuguese Register. Coordinator: João Eurico da Fonseca. Funding Agency: Sociedade Portuguesa de Reumatologia.

2019/2029: Biovas - Biobanco de vasculitis. Coordinator: João Eurico da Fonseca.

2019/2026: Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions. Coordinator: João Eurico da Fonseca. Funding Agency: European Commission.

2019/2023: Prosprective observational study to examine the change of vision-related quality of life in patients with spondyloarthritis during treatment with montly subcutaneous injections of golimumab 50 mg according to EU label. Coordinator: João Eurico da Fonseca. Funding Agency: Merck Sharp & Dohme.

2019/2022: Estudo da permeabilidade intestinal e do microbioma em doentes com lúpus eritrematoso sistémico. Coordinator: João Eurico da Fonseca. Funding Agency: L'Óreal/FCT.

2019/2022: Study of the immune-modulatory effect of Tofacitinib on B cell function in rheumatoid arthritis patients. Coordinator: João Eurico da Fonseca.

2019/2022: The role of JAK-STAT signalling pathway as key to chronic arthritis onset. Coordinator: João Eurico da Fonseca. Funding Agency: Sociedade Portuguesa de Reumatologia.

2019/2021: MILES STUDY – Mesotherapy in Lateral Epicondylitis, a prospective randomized controlled Study. Coordinator: João Eurico da Fonseca. Funding Agency: Fundação Grünenthal.

2018/2022: Immune response to Hepatitis B and Influenza vaccines in rheumatic patients under biological therapies. Coordinator: João Eurico da Fonseca. Funding Agency: Novartis.

2018/2022: Loss of follow up dos doentes sob biológicos. Coordinator: João Eurico da Fonseca. Funding Agency: Novartis.

2018/2021: Long term effect of tofacitinib on bone: friend or foe? Coordinator: João Eurico da Fonseca. Funding Agency: Sociedade Portuguesa de Reumatogia.

2017/2027: PROTEA - Prognosis of temporal arteritis. Coordinator: João Eurico da Fonseca.

2017/2022: The effect of Tofacitinib on B cells in Rheumatoid Arthritis. Coordinator: João Eurico da Fonseca. Funding Agency: Sociedade Portuguesa de Reumatologia.

2017/2022: B Cells in Juvenile Idiopathic Arthritis. Coordinator: João Eurico da Fonseca. Funding Agency: Sociedade Portuguesa de Reumatologia.

2017/2021: Preclinical evaluation of celastrol for the treatment of RA: long-term efficacy and safety in the chronic DBA/1 mice model. Coordinator: João Eurico da Fonseca. Funding Agency: Sociedade Portuguesa de Reumatologia.

2016/2022: The interplay of B and T folicullar cell subset in early arthritis patients. Coordinator: João Eurico da Fonseca.

Awards

2019 L’Oreal FCT UNESCO Women in Science Award (was awarded to Patrícia Reis).

2019 JAKIE Dr. Roberto Martins Grant - Sociedade Portuguesa de Reumatologia e Pfizer Immunology (was awarded to Rui Teixeira).

2019 Dor da Fundação Grunenthal Award (was awarded to Vitor Teixeira, Andrade P, Narciso ML, Elsa Sousa, Fernando Saraiva, João Eurico da Fonseca).

2019 EMERGE/EMEUNET Cooperation Grant (was awarded to Marques R, Rita Moura, Rosser E, Callis J, João Eurico da Fonseca).

2019 1st prize - Real Word Evidence Award-Janssen Immunology (awarded to Elsa Sousa, Eusébio M, Pedro Ávila-Ribeiro, Khmelinskii N, Machado R, Rocha TM, Bernardes M, Santos-Faria D, Leite Silva J, Santos H, Miguel C, Carvalho P, Costa T, Teixeira L, Meirinhos T, Nero P, João Eurico da Fonseca, Maria José Santos).

2014 ECTS/Amgen Bone Biology Fellowship (was awarded to Bruno Vidal).

2013 ASPIRE EU Inflammation Pfizer Research Awards. Inhibition of bone and cartilage degradation in rat induced arthritis treated with tofacitinib.

2012 Bolsa de Investigação Sociedade Portuguesa de Reumatologia/ MSD 2011 (was awarded to Elsa Sousa).

2010 Senior Clinical Award, Harvard Medical School- Portugal Program (was awarded to Helena Canhão).

2010 ECTS/Servier award 2010 (was awarded to Saba Abdulghani).

2009 Bial Prize for Clinical Medicine 2008 (was awarded to João Eurico Fonseca, Helena Canhão, Maria José Santos, Ana Filipa Mourão, Elsa Sousa, Joana Caetano Lopes, Rita Moura, Pamela Weinmann, José Alberto Pereira da Silva, Jaime Branco and Mário Viana Queiroz).

2005 EULAR Young Investigator Award from European League Against Rheumatism (EULAR),(was awarded to João Eurico Fonseca).

Selected Publications

Martins P, Teixeira V, Teixeira FJ, Canastro M, Palha A, Fonseca JE, Ponte C (2020). Giant Cell Arteritis With Normal Inflammatory Markers: Case Report and Review of the Literature. Clinical Rheumatology.

Castro Rocha FA, Duarte-Monteiro AM, Henrique da Mota LM, Matias Dinelly Pinto AC, Fonseca JE (2020). Microbes, Helminths, and Rheumatic Diseases. Best Pratice & Research Clinical Rheumatology.

Romão VC, Cruz-Machado AR, Fonseca JE (2020). No Evidence So Far on the Protective Effect of Hydroxychloroquine to Prevent COVID-19: Response to the Comment by Joob and Wiwanitkit. Annals of the Rheumatic Diseases.

Ponte C, Khmelinskii N, Teixeira V, Luz K, Peixoto D, Rodrigues M, Luís M, Teixeira L, Sousa S, Madeira N, Aleixo JA, Pedrosa T, Serra S, Campanilho-Marques R, Castelão W, Cordeiro A, Cordeiro I, Fernandes S, Macieira C, Madureira P, Malcata A, Vieira R, Martins F, Sequeira G, Branco JC, Costa L, Patto JV, da Silva JC, Pereira da Silva JA, Afonso C, Canhão H, Santos MJ, Luqmani RA, Fonseca JE (2020). Reuma.pt/vasculitis - The Portuguese Vasculitis Registry. Orphanet Journal of Rare Diseases 15(1):110.

Polido-Pereira J*, Serra S*, Teixeira F*, Ponte C, Cerqueira M, Cruz M, Araújo F, Barros R, Costa T, Faria D, Lopes C, Madruga-Dias J, Oliveira M, Teixeira RL, Vilar A, Falcão S, Saraiva F, Figueiredo G *These authors contributed equally to this manuscript (2019). Portuguese recommendations for the use of ultrasound in rheumatology. Acta Reumatológica Portuguesa 44(1):7-28.

Martins P, Marques D, Janeiro J, Romeu JC, Ponte C (2019). Tumoral calcinosis in a rheumatoid arthritis patient - a rare case report. Acta Reumatológica Portuguesa 44:158-160.

Martins P, Teixeira V, Saraiva F, Ponte C (2019). The geyser sign: an unusual presentation of a rotator cuff tear. Acta Reumatológica Portuguesa 44(2)155-157.

Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, Cassie R, Cid MC, Dasgupta B, Dejaco C, Hatemi G, Hollinger N, Mahr A, Mollan SP, Mukhtyar C, Ponte C, Salvarani C, Sivakumar R, Tian X, Tomasson G, Turesson C, Schmidt W, Villiger PM, Watts R, Young C, Luqmani RA (2019). 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Annals of the Rheumatic Diseases 79(1)19-30.

Gribbons KB, Ponte C, Carette S, Craven A, Cuthbertson D, Hoffman G, Khalidi N, Koening CL, Langford C, Maksimowicz-McKinnon K, McAlear C, Monach P, Moreland L, Pagnoux C, Quinn K, Robson JC, Seo P, Sreih AG, Suppiah R, Warrington KJ, Ytterberg S, Luqmani RA, Watts RA, Merkel PA, Grayson PC (2019). Patterns of Arterial Disease in Takayasu’s Arteritis and Giant Cell Arteritis. Arthritis Care & Research (Hoboken).

Monti S, Águeda AF, Luqmani RA, Buttgereit F, Cid M, Dejaco C, Mahr A, Ponte C, Salvarani C, Schmidt WA, Hellmich B (2019). Systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis: focus on giant cell arteritis. RMD Open 5(2):e001003.

Águeda AF, Monti S, Luqmani RA, Buttgereit F, Cid M, Dejaco C, Mahr A, Ponte C, Salvarani C, Schmidt WA, Hellmich B (2019). Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis. RMD Open 5(2):e001020.

Ponte C, Martins-Martinho J, Luqmani RA (2019). Diagnosis of Giant Cell Arteritis. Rheumatology (Oxford).

Monti S, Ponte C, Pereira C, Manzoni F, Klersy C, Rumi F, Carrara G, Hutchings A, Schmidt WA, Dasgupta B, Caporali R, Montecucco C, Luqmani RA (2019). The Impact Of Disease Extent And Severity Detected By Quantitative Ultrasound Analysis In The Diagnosis And Outcome Of Giant Cell Arteritis: Results From The Temporal Artery Biopsy Versus Ultrasound (Tabul) Study And Validation In An Independent Cohort. Rheumatology (Oxford).

Gribbons KB, Ponte C, Craven A, Robson JC, Suppiah R, Luqmani RA, Watts RA, Merkel PA, Grayson PC (2019). Diagnostic Assessment Strategies and Disease Subsets in Giant Cell Arteritis: An International Observational Cohort. Arthritis & Rheumatology.

Duarte AC, Cordeiro A, Fernandes BM, Bernardes M, Martins P, Cordeiro I, Santiago T, Seixas MI, Ribeiro AR, Santos MJ (2019). Rituximab in connective tissue disease-associated interstitial lung disease. Clinical Rheumatology 38(7):2001-2009.

Gomes JL, Sepriano A, Eusébio M, Serra S, Fonseca JE, Saavedra MJ, Cunha-Miranda L, Silva C, Bernardes M, Rosa-Gonçalves D, Costa J, Castelão W, Branco JC, Santos MJ (2019). Predictors and causes of first-line biologic agent discontinuation in rheumatoid arthritis: data from Reuma.pt. Acta Reumatológica Portuguesa 44(1):57-64.

Santos-Faria D, Tavares-Costa J, Eusébio M, Leite Silva J, Ramos Rodrigues J, Sousa Neves J, Duarte AC, Lopes C, Valido A, Dinis J, Freitas J, Santiago M, Ferreira R, Ganhão S, Miranda L, Peixoto D, Teixeira F, Alcino S, Afonso C, Santos MJ (2019). Tocilizumab and rituximab have similar effectiveness and are both superior to a second tumour necrosis factor inhibitor in rheumatoid arthritis patients who discontinued a first TNF inhibitor. Acta Reumatológica Portuguesa 44(2):103-113.

Luís M, Brites A, Duarte A, Teixeira V, Freitas R, Oliveira-Ramos F, Macieira C, Santos M, Inês L (2019). How to diagnose lupus enteritis early? Lessons learned from a multicenter case series. Acta Reumatológica Portuguesa 44(2):145-150.

Lauper K, Mongin D, Alpizar-Rodriguez D, Codreanu C, Iannone F, Kristianslund EK, Kvien TK, Pavelka K, Pombo-Suarez M, Santos MJ, Gabay C, Finckh A, Courvoisier DS (2019). Drug retention of biological DMARD in rheumatoid arthritis patients: the role of baseline characteristics and disease evolution. Rheumatology (Oxford) 58(12):2221-2229.

Lauper K, Mongin D, Iannone F, Kristianslund EK, Kvien TK, Nordström DC, Pavelka K, Pombo-Suarez M, Rotar Z, Santos MJ, Codreanu C, Lukina G, Gale SL, John M, Luder Y, Courvoisier DS, Gabay C (2019). Comparative effectiveness of TNF inhibitors and tocilizumab with and without conventional synthetic disease-modifying antirheumatic drugs in a pan-European observational cohort of bio-naïve patients with rheumatoid arthritis. Seminars Arthritis Rheumatology 50(1):17-24.

Vieira-Sousa E, Eusébio M, Ávila-Ribeiro P, Khmelinskii N, Cruz-Machado R, Martins Rocha T, Bernardes M, Santos-Faria D, Leite Silva J, Santos H, Miguel C, Carvalho P, Costa T, Duarte AC, Meirinhos T, Nero P, Fonseca JE, Santos MJ (2019). Real-World Long-Term Effectiveness of Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis patients from the Rheumatic Diseases Portuguese Register. Journal Rheumatology.

Boel A, Moltó A, van der Heijde D, Ciurea A, Dougados M, Gensler LS, Santos MJ, de Miguel E, Poddubnyy D, Rudwaleit M, van Tubergen A, van Gaalen F, Ramiro S (2019). Do patients with axial spondyloarthritis with radiographic sacroiliitis fulfil both the modified New York criteria and the ASAS axial spondyloarthritis criteria? Results from eight cohorts. Annals of Rheumatic Diseases 78(11):1545-1549.

Brahe CH, Ørnbjerg L, Jacobsson L, Nissen M, Kristianslund EK, Santos MJ, Eklund K, Rotar Z, Gudbjornsson B, Onen F, Codreanu C, Lindström U, Gabay C, Kvien TK, Barcelos A, Aaltonen K, Tomšič M, Love TJ, Can G, Ionescu R, Loft AG, Mann H, Pavelka K, Van der Sande M, Van der Horst-Bruinsma IE, Reino JG, Sánchez-Piedra C, Macfarlane GJ, Iannone F, Hyldstrup LH, Krogh NS, Østergaard M, Hetland ML (2019). Retention and response rates in 14,261 psoriatic arthritis patients starting TNF inhibitor treatment – results from 12 countries in EuroSpA. Rheumatology.

Ørnbjerg L, Brahe CH, Askling J, Ciurea A, Mann H, Onen F, Kristianslund EK, Nordström D, Santos MJ, Codreanu C, Gómez Reino J, Rotar Z, Gudbjornsson B, DiGiuseppe D, Nissen M, Pavelka K, Can G, Kvien TK, Eklund KK, Barcelos A, Ionescu R, Sánchez-Piedra C; Tomšič M, Geirsson AJ, Rusman T, Jones G, Iannone F, Hyldstrup LH, Krogh NS, Hetland ML, Østergaard M (2019). Treatment response and drug retention rates in 24,195 biologic-naïve patients with axial spondyloarthritis initiating TNFi treatment – routine care data from 12 registries in the EuroSpA collaboration. Annals of the Rheumatic Diseases 78(11):1536-1544.

Mongin D, Lauper K,Turesson C, Hetland ML, Kristianslund EK, Kvien TK, Santos MJ, Pavelka K, Iannone F, Finckh A, Courvoisier DS (2019). Imputing missing data of function and disease activity in rheumatoid arthritis registers: what is the best technique? RMD Open 5(2):e00099.

Romão VC, Polido-Pereira J, Barros R, Luís R, Vidal B, Vieira-Sousa E, Vitorino E, Humby F, Kelly S, Pitzalis C, Saraiva F, Fonseca JE (2019). Efficacy, safety and sample quality of ultrasound-guided synovial needle biopsy in clinical practice and research: a prospective observational study. Arthritis Care & Research (Hoboken).

Meyer A, Scirè CA, Talarico R, Alexander T, Amoura Z, Avcin T, Barsotti S, Beretta L, Blagojevic J, Burmester G, Cavazzana I, Cherrin P, Damian L, Doria A, Fonseca JE, Furini F, Galetti I, Houssiau F, Krieg T, Maddalena L, Launay D, Campanilho-Marques R, Martin T, Matucci-Cerinic M, Moinzadeh P, Montecucco C, Moraes-Fontes MF, Mouthon L, Neri R, Paolino S, Piette Y, Rednic S, Tamirou F, Tincani A, Toplak N, Bombardieri S, Hachulla E, Mueller-Ladner U, Schneider M, Smith V, Vieira A, Cutolo M, Mosca M, Cavagna L (2019). Idiopathic inflammatory myopathies: state of the art on clinical practice guidelines [corrected]. RMD Open 4(Suppl 1):e000784.

Martins P, Barreira SC, Melo AT, Campanilho-Marques R, Costa-Reis P, Fonseca JE, Oliveira-Ramos F (2019). Transition in a Paediatric Rheumatology Unit - experience from a tertiary unit. Acta Reumatológica Portuguesa.

Macieira C, Cunha-Miranda L, Nero P, Laires P, Bogas M, Farinha S, Freitas I, Lucas P, Sousa J, Narciso L, Mateus E, Canas da Silva J, Fonseca JE, Study Group RS Rheuma SPACE – Standard (2019). Practice Aiming Clinical Excellence: description of the methodological approach. Acta Reumatológica Portuguesa.

Antunes M, Scirè CA, Talarico R, Alexander T, Avcin T, Belocchi C, Doria A, Franceschini F, Galetti I, Govoni M, Hachulla E, Launay D, Lepri G, Macieira C, Matucci-Cerinic M, Montecucco CM, Moraes-Fontes MF, Mouthon L, Paolino S, Ramoni V, Tani C, Tas SW, Tincani A, Van Vollenhoven R, Zen M, Fonseca J, Bombardieri S, Fonseca JE, Schneider M, Smith V, Cutolo M, Mosca M, Beretta L (2019). Undifferentiated connective tissue disease: state of the art on clinical practice guidelines. RMD Open 4(Suppl 1):e000786. Review.

Martins N, Antunes AP, Macieira C (2019). Neuromyelitis Optica Spectrum Disorder in a Patient With Systemic Lupus Erythematosus. Journal of Clinical Rheumatology 25(4):38-40.

Amaro D, Carreño E, Steeples LR, Oliveira-Ramos F, Marques-Neves C, Leal I (2019). Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review. The British Journal of Ophthalmology.

Valido A, Cordeiro I (2019). Calcinosis in Systemic Sclerosis. The New England Journal of Medicine 381(17):1663.

Geenen R, Overman CL, Christensen R, Åsenlöf P, Capela S, Huisinga KL, Husebø MEP, Köke AJA, Paskins Z, Pitsillidou IA, Savel C, Austin J, Hassett AL, Severijns G, Stoffer-Marx M, Vlaeyen JWS, Fernández-de-Las-Peñas C, Ryan SJ, Bergman S (2019). EULAR recommendations for the health professional’s approach to painmanagement in inflammatory arthitis and osteoartritis. Annals of the Rheumatic Diseases 77(6)797-807.

Valido A, Crespo CL, Pimentel SF (2019). Muscle evaluation in axial spondyloarthritis – The evidence for Sarcopenia. Frontiers in Medicine 6:219.

Martins P, Fonseca JE (2019). How to investigate: Pre-clinical rheumatoid arthritis. Best Practice & Research in Clinical Rheumatology 33(4):UNSP101438.

Teixeira V, Mohammad AJ, Jones RB, Smith R, Jayne D (2019). Efficacy and safety of rituximab in the treatment of eosinophilic granulomatosis with polyangiitis. RMD Open 5(1):e000905.

Teixeira V, Barreira S, Valido A, Macieira C, Fonseca JE (2019). Outcomes of rheumatic patients referred from Portuguese speaking African countries for medical evaluation in Portugal. Acta Reumatológica Portuguesa 44(3):280-281.

Pereira E Silva R, Romão VC, Neves M, Garcia R, Oliveira S, Brites J, Ramos FO, Canhão H, Palma Dos Reis J, Pereira da Silva JA, Lopes T (2019). Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome. Lupus 28(1)27-33.

Leal IC, Brogueira Rodrigues F, Sousa DC, Duarte G, Romão VC, Neves CM, Costa J, Fonseca JE (2019). Anti-TNF Drugs for Chronic Uveitis in Adults—A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Medicine 6:104.

Romão VC, Fonseca JE (2019). Major challenges in Rheumatology: will we ever treat smarter, instead of just harder? Frontiers in Medice (Lausanne) 6:144.

Ramos-Casals M, Brito-Zerón P, Bombardieri S, Bootsma H, De Vita S, Dörner T, Fisher BA, Gottenberg JE, Hernandez-Molina G, Kocher A, Kostov B, Kruize AA, Mandl T, Ng WF, Retamozo S, Seror R, Shoenfeld Y, Sisó-Almirall A, Tzioufas AG, Vitali C, Bowman S, Mariette X, EULAR-Sjögren Syndrome Task Force Group (2019). EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies. Annals of the Rheumatic Diseases 79(1):3-18.

Miltenberger-Miltenyi, G, Cruz-Machado, AR, Saville, J, Conceição, VA, Calado, A, Lopes, I, Fuller, M, Fonseca, JE (2019). Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients. Rheumatology kez545.

Polido-Pereira J (2019). Ultrasound-Guided Biopsies: Medium and Large Joints. Frontiers in Medicine (Lausanne) 6:95. Review.

Bergstra SA, Winchow LL, Murphy E, Chopra A, Salomon-Escoto K, Fonseca JE, Allaart CF, Landewé RBM (2019). How to treat patients with rheumatoid arthritis when methotrexate has failed? The use of a multiple propensity score to adjust for confounding by indication in observational studies. Annals of the Rheumatic Diseases 78:25-30.

Canet LM, Sánchez-Maldonado JM, Cáliz R, Ramos AR, Lupiañez CB, Canhão H, Martínez-Bueno M4, Escudero A, Segura-Catena J, Sorensen SB, Hetland ML, Soto-Pino MJ, Ferrer MA, García A, Glintborg B, Filipescu I, Pérez-Pampin E, González-Utrilla A, Nevot MÁL, Conesa-Zamora P, Broeder AD, De Vita S, Jacobsen SEH, Collantes-Estevez E, Quartuccio L, Canzian F, Fonseca JE, Coenen MJH, Andersen V, Sainz J (2019). Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients. Pharmacogenomics Journal 19:83-96.

Rodrigues AM, Eusébio M, Rodrigues AB, Caetano-Lopes J, Lopes IP, Lopes A, Mendes JM, Coelho PS, Fonseca JE, Branco JC, Canhão H (2019). Low serum levels of DKK2 predict incident low-impact fracture in older women. JBMR Plus 3(7):e10179.

Sanmarti R, Veale DJ, Martin-Mola E, Escudero-Contreras A, González C, Ercole L, Alonso R, Fonseca JE, ToSpace Study group (2019). Reducing or maintaining the dose of subcutaneous tocilizumab in patients with rheumatoid arthritis in clinical remission: a randomized, open-label trial. Arthritis Rheumatology.

Sánchez-Maldonado JM, Cáliz R, Canet L, Horst RT, Bakker O, den Broeder AA, Martínez-Bueno M, Canhão H, Rodríguez-Ramos A, Lupiañez CB, Soto-Pino MJ, García A, Pérez-Pampin E, González-Utrilla A, Escudero A, Segura-Catena J, Netea-Maier RT, Ferrer MÁ, Collantes-Estevez E, López Nevot MÁ, Li Y, Jurado M, Fonseca JE, Netea MG, Coenen MJH, Sainz J (2019). Steroid Hormone-Related Polymorphisms Associate with the Development of Bone Erosions in Rheumatoid Arthritis and Help to Predict Disease Progression: Results from the Repair Consortium. Scientific Reports 9(1):14812.

Araújo FC, Gonçalves J, Fonseca JE (2019). Biosimilars in Rheumatology. Pharmacology Research 149:UNSP104467. Review.

Antunes M, Scirè CA, Talarico R, Alexander T, Avcin T, Belocchi C, Doria A, Franceschini F, Galetti I, Govoni M, Hachulla E, Launay D, Lepri G, Macieira C, Matucci-Cerinic M, Montecucco CM, Moraes-Fontes MF, Mouthon L, Paolino S, Ramoni V, Tani C, Tas SW, Tincani A, Van Vollenhoven R, Zen M, Fonseca J, Bombardieri S, Fonseca JE, Schneider M, Smith V, Cutolo M, Mosca M, Beretta L (2019). Undifferentiated connective tissue disease: state of the art on clinical practice guidelines. RMD Open 4(Suppl 1):e000786.

Rocha FAC, Girão VCC, Nunes RM, Pinto ACMD, Vidal B, Fonseca JE (2019). Cell sources of inflammatory mediators present in bone marrow areas inside the meniscus. PLoS One 14(12):e0226986.

Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C, PEAC- R4RA investigators (2019). B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Arthritis Rheumatology.

Valido A, Silva-Dinis J, Saavedra MJ, Iria I, Gonçalves J, Lopes JP, Fonseca JE. Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center. Acta Reumatológica Portuguesa.

Martins N, Polido-Pereira J, Caneira M, Fonseca JE (2019). Treatment of Persistent Cutaneous Atrophy After Corticosteroid Injection With Fat Graft. Reumatologia Clinica 15(6):e122-e124.

Cascão R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca JE, Moita LF (2014). Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis. Mediators of Inflammation 2014:195327.

Carmona-Fernandes D, Santos MJ, Canhão H, Fonseca JE (2013). Anti-ribosomal P protein IgG autoantibodies in patients with systemic lupus erythematosus: diagnostic performance and clinical profile. BMC Medicine 11: R196.

Vale AC, Aleixo IP, Lúcio M, Saraiva A, Caetano-Lopes J, Rodrigues A, Amaral PM, Rosa LG, Monteiro J, Fonseca JE, Vaz MF, Canhão H (2013). At the moment of occurrence of a fragility hip fracture, men have higher mechanical properties values in comparison with women. BMC Musculoskeletal Disorders 16;14:295.

Moura RA, Canhão H, Polido-Pereira J, Rodrigues AM, Navalho M, Mourão AF, Resende C, Campanilho-Marques R, Dias JM, da Silva JA, Graca L, Fonseca JE (2013). BAFF and TACI Gene Expression Are Increased in Patients with Untreated Very Early Rheumatoid Arthritis. Journal of Rheumatology 40:1293-302.

Caetano-Lopes J, Rodrigues A, Lopes A, Vale AC, Pitts-Kiefer MA, Vidal B, Perpétuo IP, Monteiro J, Konttinen YT, Vaz MF, Nazarian A, Canhão H, Fonseca JE (2013). Rheumatoid Arthritis Bone Fragility Is Associated With Upregulation of IL17 and DKK1 Gene Expression. Clinical Reviews in Allergy & Immunology.

Vidal B, Pinto A, Galvão MJ, Santos AR, Rodrigues A, Cascão R, Abdulghani S, Caetano-Lopes J, Ferreira A, Fonseca JE, Canhão H (2012). Bone histomorphometry revisited. Acta Reumatológica Portuguesa 37(4):294-300.

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