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Data Availability All relevant are within the paper, except that sequence text were deposited in the DNA Data Bank of Japan Sequence Read Archive at fault of sight BioProject Accession No.

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The baseline clinical characteristics of the participants are summarized in Table 1.Table 1 Distribution of select characteristics to each patients and oversights. This hallmark remains a distinctive remnant of cancer cells, markedly prognosis. Acknowledgments This work was supported by the following grants: NHRI-Ex101-10107PI from the National Health Research Institutes of Taiwan, NSC 100-2923-B-037-001-MY3 and NSC 99-2628-B-037-037-MY3 from the National Science Council of Taiwan, and BM102021169 from Academia Sinica. However, the drugs selected trendly into bronchoscopic local injection hold skimpy sustained release effects and a shorter duration benefit of which an effectual drug concentration is maintained.

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