Ramirez, Mário
Lab

• Áreas de Investigação

  • Epidemiologia e biologia populacional
  • Genómica de bacteriófagos
  • Mecanismos de resistência microbiana
  • Novas técnicas de diagnóstico
  • Bioinformática

• Equipa de Investigação

• Projectos de Investigação em Curso

  • 2009/2012 CAREPNEUMO – Combating antibiotic resistance pneumococci by novel strategies based on in vivo and in vitro host-pathogen interactions (FP7-HEALTH-2007-223111)
  • 2009/2012 Implications for therapy and disease presentation of the changes triggered by the use of the pneumococcal 7-valent conjugate vaccine (PIC/IC/83065/2007)
  • 2008/2011 Streptococcus pyogenes invasive disease and antimicrobial resistance - two faces of a changing pathogen (PTDC/SAU-ESA/72321/2006)
  • 2008/2011 Population and genomic consequences of vaccination against Streptococcus pneumoniae (PTDC/SAU-ESA/64888/2006)
  • 2008/2011 A computational biology approach using Streptococcus pneumoniae as a model towards an integrative view of bacteria/host interactions and evolution (PTDC/SAU-ESA/71499/2006)
  • 2007/2010 Caracterização microbiológica e molecular de Streptococcus spp. patogénicos e sua importância na profilaxia e terapêutica das infecções humanas em Portugal. Fundação Calouste Gulbenkian.
  • 2006/2009 Population based identification of pneumococcal virulence and colonization factors. National Institutes of Health – National Institute of Allergy and Infectious Diseases (NIH/NIAD). Pathogen Functional Genomics Resource Center (PFGRC) Program.

• Prémios

• Publicações Seleccionadas

  • Hänscheid, T., Egan, T.J., Grobusch, M.P. 2007. Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator. Lancet Infect. Dis. 7:675-685.
  • Carriço, J.A., C. Silva-Costa, J. Melo-Cristino, F. R. Pinto, H. de Lencastre, J.S. Almeida, M.Ramirez. 2006. Illustration of a common framework for relating multiple typing methods by application to macrolide- resistant Streptococcus pyogenes. J. Clin. Microbiol. 44:2524-2532.
  • Pinho, M. D., J. Melo-Cristino, M. Ramirez, and the Portuguese group for the study of streptococcal infections. 2006. Clonal relationships between invasive and noninvasive lancefield group C and G Streptococci and emm-specific differences in invasiveness. J. Clin. Microbiol. 44:841-846.
  • Silva-Costa, C., M. Ramirez, and J. Melo-Cristino. 2005. Rapid inversion of the prevalences of macrolide resistance phenotypes paralleled by a diversification of T and emm types among Streptococcus pyogenes in Portugal. Antimicrob. Agents Chemother. 49:2109-2111.
  • Serrano, I., J. Melo-Cristino, J. A. Carriço, and M. Ramirez. 2005. Characterization of the genetic lineages responsible for pneumococcal invasive disease in Portugal. J. Clin. Microbiol. 43:1706-1715.
  • Hänscheid T, Melo Cristino J, Salgado MJ. Screening of auramine stained smears of all fecal samples is a rapid and inexpensive way to increase the detection of coccidial infections. 2008. Int J Infect Dis; 12(1):47-50.
  • Hänscheid T. The future looks bright: low-cost fluorescent microscopes for detection of Mycobacterium tuberculosis and Coccidiae. 2008. Trans R Soc Trop Med Hyg; 102:520-1.
  • Shapiro HM, Hänscheid T. Fuchsin fluorescence in Mycobacterium tuberculosis: The Ziehl-Neelsen stain in a new light. 2008. J Microbiol Methods; 74: 119-120. [IF=2.153]
  • Vicente A, Barros R, Florinda A, Silva A, Hänscheid T. 2008. High rates of fluoroquinolone-resistant Campylobacter in Portugal--need for surveillance. Euro Surveill; 13. pii: 8031.
  • Hänscheid T, Längin M, Lell B, Pötschke M, Oyakhirome S, Kremsner PG, Grobusch MP. 2008. Full blood count and haemozoin-containing leukocytes in children with malaria: diagnostic value and association with disease severity. Malar J 12; 7:109.
  • Pinto, F. R., J. Melo-Cristino, and M. Ramirez. 2008. A confidence interval for the Wallace coefficient of concordance and its application to microbial typing methods. PLoS ONE 3:e3696.
  • Aguiar, S. I., I. Serrano, F. R. Pinto, J. Melo-Cristino, M. Ramirez, and the Portuguese Surveillance Group for the Study of Respiratory Pathogens. 2008. Changes in pneumococcal invasive disease with non-universal vaccination coverage of the seven-valent conjugate vaccine. Clin. Microbiol. Infect. 14:835-843.
  • Silva-Costa, C., F. R. Pinto, M. Ramirez, J. Melo-Cristino, and the Portuguese Surveillance Group for the Study of Respiratory Pathogens. 2008. Decrease in macrolide resistance and clonal instability among Streptococcus pyogenes in Portugal. Clin. Microbiol. Infect. 14:1152-1159.
  • Pinto, F. R., S. I. Aguiar, J. Melo-Cristino, and M. Ramirez. 2008. Optimal control and analysis of two-color genomotyping experiments using bacterial multistrain arrays. BMC Genomics 9:230.
  • Aguiar, S. I., I. Serrano, F. R. Pinto, J. Melo-Cristino, and M. Ramirez. 2008. The presence of the pilus locus is a clonal property among pneumococcal invasive isolates. BMC Microbiol 8:41.

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