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Ferreira, Joaquim
Lab

Farmacologia Clínica

O objetivo do nosso laboratorio é contribuir para o desenvolvimento de intervenções terapêuticas eficazes e seguras, através da implementação de metodologias otimizadas para o desenho, condução, análise e publicação de ensaios clínicos.
Os modelos clínicos principais das nossas atividades de investigação são as doenças neurodegenerativas (particularmente Doença de Parkinson e Doença de Huntington), populações específicas (ex. população pediátrica, doenças raras, populações em fase tardia de doença) e intervenções órfãs (ex. reabilitação e intervenções não farmacológicas).

As principais áreas de interesse no âmbito da farmacologia clinica são a metodologia de ensaios clínicos, outcomes, revisões sistemáticas, segurança e utilização de medicamentos
Outros objetivos:
1. Desenvolver novas metodologias para o desenho de ensaios exploratórios e estudos com biomarcadores como preditores do efeito de medicamentos em ensaios clínicos.
2. Facilitar a componente de translação de investigação relacionada com o desenho e condução de estudos em humanos com medicamentos em fase inicial de desenvolvimento.
3. Organizar e prestar serviços no âmbito da farmacologia clínica a outros grupos de investigação do CHLN, FMUL e iMM Lisboa.
4. Educar e treinar em metodologia de ensaios clínicos e Boas Práticas Clínicas.
5. Promover ensaios de iniciativa do investigador.
6. Promover colaborações com a indústria farmacêutica a outros potenciais parceiros.

  • Áreas de Investigação

    Clinical Trials Sub-Unit

    Pharmaco MRI Sub-unit

    Biostatistics and Methodological Sub-Unit

    Outcomes Sub-Unit

    Drug Evalutaion and Systematic Reviews Sub-Unit

    Safety and Drug Utilization Research Sub-Unit

  • Equipa de Investigação

    • Projectos de Investigação em Curso

       

      NOME ORCID
      Joaquim Ferreira, MD PhD 0000-0003-3950-5113
      Daniel Caldeira, MD PhD 0000-0002-2520-5673
      Ricardo Fernandes, MD PhD 0000-0002-7253-6475
      Mário Miguel Rosa, MD, PhD  0000-0003-3158-2106 
      Miguel Coelho, MD, PhD  0000-0002-4008-8110 
      Sofia Reimão, MD, PhD  0000-0002-8822-3166 
      João Costa, MD, PhD  0000-0002-5831-4921
         
         
      • 2014 COURAGE-PD - Avaliação Abrangente e Não Enviesada de Fatores de Risco Genéticos e Ambientais para a Doença de Parkinson. Financiado pelo JPND (€ 130.000)
      • 2014 CLaSP - Cuidados para Parkinsonismo em Estádio Avançado. Financiado pelo JPND (€110.000)
      • 2014 FraLusoPark - Disartria na Doença de Parkinson: uma comparação entre a Francofonia e a Lusofonia. Financiado pela ANR (€151.686)
      • 2013 Imagens de Gânglios da Base por Tomografia de Indução Magnética. Financiado pela Fundação para a Ciência e Tecnologia
      • 2013 Glicocerebrosidade na doença de Parkinson: dos fatores de risco para os biomarcadors. Financiado pela Fundação para a Ciência e Tecnologia
      • 2012 Projeto SENSE-PARK (2012-2015): Supporting and Empowering Parkinson patients in their home environment using a Novel Sensory information system that monitors daily life-relevant parameters of Parkinson disease and their change. Financiado pelo FP7 (€214.880)
      • 2010 Estudo epidemiológico para avaliar a prevalência da doença de Parkinson em Portugal. Promovido pela Associação Português de Doentes com Doença de Parkinson e patrocinado pela Administração Regional de Saúde (€150.000)
      • 2008/2011 Progressão Lenta e Rápida em Doença de Parkinson: Determinantes Moleculares e Biomarcadores. Financiado pela Fundação para a Ciência e Tecnologia. (€195.000

      2014/2016: Ablynx N.V. Coordinator: Ricardo Miguel Ribeiro Marques Cunha Fernandes. Agency: Ablynx N.V. Reference: Ablynx. Amount (total): 3000.00.

    • Prémios

      Joaquim Ferreira, Caixa Geral de Depósitos Science Honor Prize 2015.

      Joaquim Ferreira, Caixa Geral de Depósitos Science Award 2016.

      Daniel Caldeira, Bolsa de Interno-Doutorando pela Fundação para a Ciência e Tecnologia (FCT) SFRH/SINTD/96409/2013 (2013).

      Daniel Caldeira, Melhor poster na sessão “Health technology assessment in cardiovascular disease", promovido pelo CUTEheart, no XXXVII Congresso Português de Cardiologia 2016.

      Daniel Caldeira, Distinguido em Janeiro de 2017 pela Revista Portuguesa de Factores de Risco como autor do artigo publicado em 2014, mais lido em formato digital “Café e hipertensão arterial: um dilema?”.

    • Publicações Seleccionadas

      Ferreira JJ, Lees A, Rocha JF, Poewe W, Rascol O, Soares-da-Silva.Bi-Pk 1 Investigators. Opicapone as an adjunct to levodopa in patients with Parkinson´s disease end end-of-dose motor fluctuations: a randomised, double-blind controlled trial. Lancet Neurology 2016, 15(2): 154-165. IF: 21.90.

      Rodrigues FB, Neves JB, Caldeira D, Ferro JM, Ferreira JJ, Costa J. Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis. BMJ 2016, 353: i1754. IF: 59.558.

      Caldeira D, Costa J, FERREIRA JJ. Bridging anticoagulation in patients with atrial fibrillation. New England Journal of Medicine 2016, 374(1):91-92

      Reimão S, Ferreira, S, Nunes RG, Lobo PP, Neutel D, Abreu D, Gonçalves N, Campos J, FERREIRA JJ (2016) Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson’s disease. European Journal of Neurology 368-374, 23(2). (Journal IF: 4.06, Citations: 6).

      Valadas A, Contarino MF, Albanese A, Bhatia KP, Falup-Pecurariu C, Forsgren L, Friedman A, Giladi N, Hutchinson M, Kostic VS, Krauss K, Lokkegaard A, Marti MJ, Milanov I, Pirtosek Z, Relja M, Skorvanek M, Stamelou M, Stepens A, Tamas G, Taravari A, Tzoulis C, Vandenberghe W, Vidailhet M, FERREIRA JJ, Tijssen MA. (2016) Management of dystonia in Europe: a survey of the European network for the study of the dystonia syndromes. European Journal of Neurology 23(4), 772-779. (Journal IF: 4.06, Citations: 0).

      Caldeira D, Costa J, FERREIRA JJ (2016) Bridging anticoagulation in patients with atrial fibrillation. New England Journal of Medicine 374(1), 91-92. (Journal IF: 59.558, Citations: 0)

      2015

      Teodoro T, Viana P, Abreu D, Conceição I, Peralta R, Ferreira JJ. (2015). A peripheral pathway to restless legs syndrome? Clues from familial amyloid polyneuropathy. Parkinsonism & Related Disorders. 21 (12): 1465-1468. (Journal IF: 3.972, citations: 0)

      Caldeira D, Barra M, Ferreira A, Rocha A, Augusto A, Pinto FJ, Costa J, Ferreira JJ (2015) Systematic review with meta-analysis: the risk of major gastrointestinal bleeding with non-vitamin K antagonist oral anticoagulants. Alimentary pharmacology & therapeutics,42 (11-12): 1239-49 (Journal IF: 5.727, citations: 0)

      Rodríguez-Blázquez C, Forjaz MJ, Lizán L, Paz S, Martínez-Martín P. (2015) Estimating the direct and indirect costs associated with Parkinson's disease. Expert Rev Pharmacoecon Outcomes Res., 15(6), 889-911. (Journal IF: 1.669, citations: 0))

      Margherita Fabbri, Mário M Rosa, Daisy Abreu, Joaquim J Ferreira. (2015) Clinical pharmacology review of safinamide for the treatment of Parkinson’s disease. Neurodegenerative disease management 5(6): 481496.  (Journal IF: not indexed)

      Caldeira D, Ferreira JJ, Costa J. (2015) Glaucoma Surgery and Anticoagulant Therapy Reply. Jama Ophtalmology, 133 (11): 1365-1365. Journal IF: 3.318, citations: 0)

      Sinha, IP, McBride, AKs, Smith, R, Fernandes, RM. (2015)  CPAP and high-flow nasal cannula in brochiolotis. Chest, 148(3): 810-823. (Journal IF: 7.483, citations: 0)

      Neutel D, Peralta R, Pires J, Bentes C, Ferreira JJ. (2015) End of OSLER test sessions in Parkinson's disease do not correspond to true sleep onset: results from an exploratory study. Frontiers in Neurology, Volume: 6, 200. (Journal IF: not indexed, citations: 0)

      Rascol O, Perez-Lloret S, Ferreira JJ. (2015) New treatments for levodopa-induced motor complications. Movement Disorders, 30(11):1451-1460. (Journal IF: 4.983; citations: 0)

      Caldeira D, Costa J, Barra M, Pinto JF, Ferreira JJ (2015) How safe is acetaminophen use in patients treated with vitamin K antagonists? A systematic review and meta-analysis. Thrombosis Research 135(1):58-61  (Journal IF: not indexed,; Citations: 0)

      Caldeira D, Barra M, Santos AT, de Abreu D, Costa J, Ferreira JJ (2015) Risk of insomnia with non-vitamin K oral anticoagulants: systematic review and meta-analysis. Sleep and Breathing. 19(3):1043-9 (Journal IF: 2.482, citations: 0).

      Ferreira JJ, Rosser, A,Craufurd, D, Squitieri, F,;Mallard, N, Landwehrmeyer, B, Ethyl-Eicosapentaenoic Acid Treatment in Huntington's Disease: A Placebo-Controlled Clinical Trial, Movement Disorders, 30(10): 1426-1429. (Journal IF: 5.680, citations: 0).

      Teodoro T, Nzwalo H, Correia Guedes L, Coelho M, Rosa MM, FERREIRA JJ. (2015) Suicidal behaviors are very rare in antiparkinsonian drug trials. Parkinsonism and related Disorders. 21(8):1008-9 . (Journal IF: 3.972, citations: 0). 

      Neame M, Aragon O, Fernandes RM, Sinha I. (2015) Salbutamol or aminophylline for acute severe asthma: how to choose which one, when and why? Archives of disease in childhood-Education & practice edition, 100(4): 215-22. (journal IF: 1.453, citations: 1)

      Caldeira D, Gonçalves N, Ferreira JJ, Pinto FJ, Costa J. (2015) Tolerability and Acceptability of Non-Vitamin K Antagonist Oral Anticoagulants in Atrial Fibrillation: Systematic Review and Meta-Analysis. American Journal of Cardiovascular Drugs. 15(4):259-65. (Journal IF: 2.422, citations: 0). 

      Caldeira D, Rodrigues FB, Barra M, Santos AT, de Abreu D, Gonçalves N, Pinto FJ, Ferreira JJ, Costa J. (2015) Non-vitamin K antagonist oral anticoagulants and major bleeding-related fatality in patients with atrial fibrillation and venous thromboembolism: a systematic review and meta-analysis. Heart. 101(15):1204-11. (Journal IF: 5.595, citations: 0).

      Caldeira D, Canastro M, Barra M, Ferreira A, Costa J, Pinto FJ, Ferreira JJ. (2015) Risk of Substantial Intraocular Bleeding With Novel Oral Anticoagulants: Systematic Review and Meta-analysis. JAMA Ophthalmology. 33(7):834-9.(Journal IF: 3.318, citations: 0).

      Caldeira D, Costa J, Ferreira JJ, Lip GY, Pinto FJ. (2015) Non-vitamin K antagonist oral anticoagulants in the cardioversion of patients with atrial fibrillation: systematic review and meta-analysis. Clinical Research Cardiology. 104(7):582-90. (Journal IF: 2.939, citations: 0). 

      Caldeira D, Gonçalves N, Pinto FJ, Costa J, Ferreira JJ. (2015) Risk of renal failure with the non-vitamin K antagonist oral anticoagulants: systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 24(7):757-64. (Journal IF: 2.935, citations: 0). 

      Teodoro, T, Lobo, PP, Ferreira, J, Sousa,  Reimao, S, Peralta, R, Albuquerque, L, Ferreira JJ, Delayed Parkinsonism after acute chorea due to non-ketotic hyperglycemia, Journal of the Neurological Sciences. 354(1-):116-117. (Journal IF: 2.474 , citations: 0).

      Ferreira  JJ, Godinho C, Santos AT, Domingos J, Abreu D, Lobo R, Gonçalves N, Barra M, Larsen F, Fagerbakke O, Akeren I, Wangen H, Serrano JA, Weber P, Thoms A, Meckler S, Sollinger S, van Uem J, Hobert MA, Maier KS, Matthew H, Isaacs T, Duffen J, Graessner H, Maetzler W. (2015) Quantitative home-based assessment of Parkinson´s symptoms: The SENSE-PARK feasibility and usability study. BMC Neurology, 15(89). (Journal IF: 2.040; citations: 0)

      (Journal IF: 2.563, citations: 1).

      Martinez-Martin P, Rodriguez-Blazquez C, Forjaz MJ, Frades-Payo B, Agüera-Ortiz L, Weintraub D, Riesco A, Kurtis MM, Chaudhuri KR. (2015) Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease. Parkinsonism Relat Disord., 629-34.  (Journal IF: 3.972, citations: 1)

      Fernandes RM, Plint AC, Terwee CB, Sampaio C, Klassen TP, Offringa M, van der Lee JH. Validity of bronchiolitis outcome measures. Pediatrics, 2015;135:e1399-408. (Jornal IF: 5.473, citations:1)

      Caldeira D, Costa J, Vaz-Carneiro, A, Analysis of the Cochrane Review: Influenza Vaccines for Preventing Cardiovascular Disease. Cochrane Database Syst Rev. 2015; 5: CD005050. Acta Medica Portuguesa. 28(4): 424-426. (Journal IF: 0.360, citations: 0).

      Reimão S, Pita Lobo P, Neutel D, Correia Guedes L, Coelho M, Rosa MM, Azevedo P, Ferreira J, Abreu D, Gonçalves N, Nunes RG, Campos J, Ferreira JJ (2015) Substantia nigra neuromelanin-MR imaging differentiates Essential tremor from Parkinson’s disease. Movement Disorders Jun; 30(7):953-959. (Journal IF: 5.668; citations:0)

      Rodrigues IT, Ferreira JJ, Coelho M, Rosa MM, Castro-Caldas A, (2015) Action verbal fluency in Parkinson´s patients. Arquivos de Neuro-Psiquiatria, 73(6):520-525. (Journal IF: 0.843, citations: 0). 

      Santos J, Alarcão J, Fareleira F, Vaz-Carneiro A, Costa J. (2015) Tapentadol for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev.27;5.:CD009923 (Journal IF: not indexed).

      Caldeira D, Cotrim, C, Cale, R, Cruz, I, Stuart, B, Pereira, H,(2015) Left ventricular thrombus in repaired Tetralogy of Fallot. International Journal of Cardiology 187: 363-364. (Journal IF: 4.036, citations: 0).

      Ferreira JJ. Rocha JF, Falcão A, Santos A, Pinto R, Nunes T, Soares da Silva, P. (2015)  Effect of opicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity and motor fluctuations in patients with Parkinson´s disease. European Journal of Neurology, 22(5): 815-E56. (Journal IF: 4.055, citations: 0

      Maetzler W, Karam M, Berger MF, Heger T, Maetzler C, Ruediger H, Bronzova J, Lobo PP, Ferreira JJ, Ziemssen T, Berg D. (2015)  Time and frequency-domain parameters of heart rate variability and sympathetic skin response in Parkinson´s disease. Journal of Neural Transmission, 112(3): 419-425. (Journal IF: 1.071 citations: 1 0)

      Reimão S, Lobo PP, Neutel D, Guedes LC, Coelho M, Rosa MM, Ferreira J, Abreu D, Gonçalves N, Morgado C, Nunes RG, Campos J, Ferreira JJ. (2015). Substantia nigra neuromelanin magnetic imaging in de novo Parkinson’s disease patients. European Journal of Neurology, 22(3): 540-546. (Journal IF: 4.055, citations: 0)

      Caldeira D, Barra M, Pinto FJ, Ferreira JJ. Costa J. (2015) Intracranial hemorrhage risk with the new oral anticoagulants: a systematic review and meta-analysis. Journal of Neurology, 262(3): 516-522. (Journal IF: 3.377, citations: 7).

      Caldeira D, Barra M, Gonçalves N, Pinto FJ, FERREIRA JJ, Costa J, Pericardial bleeding risk with non-vitamin K oral anticoagulants: a meta-analysis (2015) International Journal of Cardiology, 182:187-188. (Journal IF: 4.036; citations: 0).

      Gouveia M, Sousa R, Costa J, Borges M. (2015) Economic Evaluation of Suboxone® for substitution treatment of opioid drug dependence in Portugal. Heroin Addiction and Related Clinical Problems, 17(1): 43-50. (Journal IF: 0.643, citations: 0)

      Ferreira JJ, Santos AT, Domingos J, Matthews, H , Isaacs, T, Duffen, J, Al-Jawad, A, Larsen, F, Serrano, JA, Weber, P, Thoms, A, Sollinger, S, Graessner, H, Maetzler, W. (2015) Clinical Parameters and Tools for Home-Based Assessment of Parkinson's Disease: Results from a Delphi study, Journal of Parkinson´s Disease, 5(2): 281-290. (Journal impact factor: 1.910, citations: 0)

      Caldeira D, Lopes LR, Carmona, S, Gomes, C, Cruz, I, Joaquim, SD,  Pereira, H, Santos, AI, Takotsubo cardiomyopathy, beyond ventriculography and classical bidimensional echocardiography, International Journal of Cardiology. 182: 381-383. (Journal IF: 4.03, citations: 1)

      Ratilal BO, Costa J, Pappamikail L, Sampaio C. (2015) Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures. Cochrane Database Syst Rev. 28;4. (Journal IF: 6.539, citations: 0)

      Ferreira JJ. Colosimo C, Bhidayasiri R, Marti MJ, Maisonobe P, Om S. (2015) Factors influencing secondary non-response to botulinum toxin type A injections in cervical dystonia. Parkinsonism and  Related Disorders, 21(2): 111-115. (Journal IF: 3.972, citations: 1). 

      Coelho M, Marti MJ, Sampaio C, FERREIRA JJ, Valldeoriola F. (2015) Dementia and severity of parkinsonism determines the handicap of patient´s in late-stage Parkinson´s disease: the Barcelona-Lisbon cohort. European Journal of Neurology, 22(2):305-312. (Journal IF: 4.055, citations: 1). 

      Sousa Nanji L, Torres Cardoso A, Costa J, Vaz-Carneiro A. (2015) [Analysis of the Cochrane Review: thrombolysis for acute deep vein thrombosis. Cochrane Database Syst Rev. 2014,1: CD002783]. Acta Médica Portuguesa, 28(1):12-4. (Journal IF: 0.360: citations: 0).

      Caldeira D, Cruz I, Calé R, Martins C, Pereira H, Ferreira JJ, Pinto FJ, Costa J, (2015). Antithrombotic treatment in chronic heart failure and sinus rhythm: Systematic review. World Journal of Meta-Analysis, 3(1):36 -42. (Journal IF: not indexed) 

      Caldeira D, Costa J, FERREIRA JJ, Pinto FJ. (2015) Thromboembolic risk in the initiation, swich and interruption/re-initiation of oral anticoagulants: Do newcomers improve outcomes? Insights from a meta-analysis of RCTs.  International Journal of Cardiology, 177(1): 117-119. (Journal IF: 4.036, citations: 0).

      Serrano JA, Larsen F, Isaacs T, Matthews H, Duffen J, Riggare S, Capitanio F, Ferreira JJ, Domingos J, Maetzler W, Graessner H. Sense Park Consortium. (2015) Participatory design in Parkinson’s research with focus on the symptomatic domains to be measured. Journal of Parkinson´s Disease. 5(1): 187-196. (Journal IF: 1.910, citations: 0). 

      Caldeira D, Costa J, Barra M, Pinto FJ, FERREIRA JJ. (2015) How safe is acetaminophen use in patients treated with vitamin K antagonists? A systematic review and meta-analysis. Thrombosis Research, 135(1): 58-61. (Journal IF: 2.427, citations: 0)

      Reimao S, Lobo PP, Neutel D, Guedes LC, Coelho M, Rosa MM, Ferreira JJ,  Abreu, D, Goncalves N,  Morgado C, Nunes RG, Campos, J, Ferreira, JJ. (2015). Quantitative Analysis Versus Visual Assessment of Neuromelanin MR Imaging for the Diagnosis of Parkinson's disease, Journal of Parkinson´s Disease, 5(3): 561-567. (Journal IF: 1.910, citations: 0)

      Gouveia M, Costa J, Alarcão J, Augusto M, Caldeira D, Pinheiro L, Vaz Carneiro A, Borges M. (2015) Burden of disease and cost of illness of atrial fibrillation in Portugal. Revista Portuguesa de Cardiologia, 34(1):1-11. (Journal IF: 0.454; citations: 0)

      Fabbri M, Guedes LC, Simão M, Abreu D, Rosa MM, Silveira-Moryama L, Ferreira JJ.  (2015) Subthalamic deep brain stimulation effects on odor identification in Parkinson’s disease. European Journal of Neurology, 22(1): 207-210. (Journal IF: 4.055; citations: 2)

      Caldeira D, Lopes LR, Vaz-Carneiro A, Costa J. (2015) Cochrane Corner:  Corticosteroids for viral myocarditis. Revista Portuguesa de Cardiologia, 34(1):65-7. (Journal IF: 0.454; citations: 0)

      Domingos JM,  Godinho C, Dean J, Coelho, M, Pinto A, Bloem BR, Ferreira J. (2015) Cognitive Impairment in Fall-Related Studies in Parkinson's Disease. Journal of Parkinsons Disease, 5(3):453-469 (Journal IF: 1.910, citations: 0)

      Caldeira D, Vaz-Carneiro A, Costa J. (2015) Cochrane Corner: Colchicine in acute and recurrent pericarditis. Rev Port Cardiol 34(11):697-699.

      Cruz I, Caldeira D, Stuart B, Cotrim C, João I, Pereira H. (2015) Complications of myocardial infarction: Echocardiography for differential diagnosis of heart murmur. Rev Port Cardiol34:781-783.

      Costa J, Fiorentino F, Caldeira D, Inês M, Lopes Pereira C, Pinheiro L, Vaz-Carneiro A, Borges M, Gouveia M. (2015) Cost-effectiveness of non-vitamin K antagonist oral anticoagulants for atrial fibrillation in Portugal. Rev Port Cardiol 34:723-737.

       

      2014

      Caldeira D, Barra M, Santos AT, de Abreu D, Pinto FJ, Ferreira JJ, Costa J, (2014), Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysis. Heart, 100(7):550-6. (Journal IF: 13.857; Citations: 2)

      Fernandes R, Hartling L, (2014), Glucocorticoids for Acute Viral Bronchiolitis in Infants and Young children, Jama, 311(1): 87-88. (Journal IF: 29.978, Citations: 0)

      Munafo M, Noble S, Bowne WJ, Brunner D, Button K, Ferreira J, Holmans P, Langbehn D, Lewis G, Lindquist M, Tilling K, Wagenmakers EJ, Blumesntein R, (2014), Scientific rigor and the art of motorcycle maintenance. Nature Biotechnology, 32(9): 871-873. (Journal IF: 39.080; Citations: 0

      Hill DLG, Scharwz AJ, Isaac M, Pani L, Vamvakas S, Hemmings R, Carrillo MC, Yu P, Sun J, Beckett L, Boccardi M, Brewer J, Brumfield M, Cantillon M, Cole PE, Fox N, Frisoni GB, Jack C, Kelleher T, Luo F, Novak G, MAguite P, Meibach R, Patterson P, Bain L, Sampaio C, Raunig D, Soares H, Suhy J, Wang HL, Wolz R, Stephenson D, (2014), Coalition against major diseases/European medicines agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer’ disease. Alzheimer’s and Dementia, (10)4: 421-429.  (Journal IF: 14.472; Citations: 1)

      Reimão S, Pita Lobo P, Neutel D, Correia Guedes L, Coelho M, Rosa MM, Ferreira J, Abreu D, Gonçalves N, Morgado C, Nunes RG, Campos J, Ferreira JJ,  (2014) Substantia nigra  neuromelanin magnetic resonance imaging in de novo Parkinson's disease patients.  European Journal of Neurology doi: 10.1111/ene.12613. [Epub ahead of print.]

      Caldeira D, Lopes R, Cruz I, Almeida AR, Gomes C, Stuart B, Almeida S, Brandão L, Pereira H, (2014), The burnout stage of an epical hypertrophic cardiomyopathy. International journal of cardiology, 177(3):179-80. (Journal IF:6.175; Citations:0)

      Caldeira D, Costa J, Ferreira JJ, Pinto FJ, (2014), Thromboembolic risk in the initiation, switch and interruption/re-initiation of oral anticoagulants: do newcomers improve outcomes? Insights from a meta-analysis of RCTs. International Journal of Cardiology. 177: 117–119. (Journal IF: 2.298; Citations: 1)

      Munafo M, Noble S, Bowne WJ, Brunner D, Button K, Ferreira J, Holmans P, Langbehn D, Lewis G, Lindquist M, Tilling K, Wagenmakers EJ, Blumesntein R, (2014), Scientific rigor and the art of motorcycle maintenance. Nature Biotechnology, 32(9): 871-873. (Journal IF: 39.080; Citations: 0

      Vaz-Carneiro A, Luz R, Borges M, Costa J, (2014), [Primary and secondary outcomes in oncology clinical trials: definitions and uses]. Acta Médica Portuguesa, 27(4):498-502. (Journal IF: 0.281; Citations: 0)

      Caldeira D, Vaz-Carneiro A, Costa J, (2014), Cochrane Corner: What is the clinical impact of oxygen therapy for acute myocardial infarction? Evaluation of a Cochrane systematic review. Revista Portuguesa de Cardiologia . (Journal IF: 0.525, Citations: 0)

      Fernandes RM, Oleazczuk, Woods CR, Rowe BH, Cates CJ, Hartling L, (2014) The Cochrane Library and safety of systemic corticosteroids for acute respiratory conditions in children: an overview of reviews. Evidence-Based Child Health 9(3):733-747 (Journal IF: not indexed; Citations:

      Mestre TA, Teodoro T, Reginold W, Graf J, Kasten M, Sale J, Zurowsky M, Miasaki J, Ferreira JJ, Marras C, (2014), Reluctance to start medication for Parkinson´s disease: A mutual misunderstanding by patients and physicians. Parkinsonism and Related Disorders, 20(6): 608-612.  (Journal IF: 3.274; Citations: 0)

      Caldeira D, Costa J, Fernandes RM, Pinto FJ, Ferreira JJ, (2014), Performance of the HAS-BLED high bleeding-risk category, compared to ATRIA and HEMORR2HAGES in patients with atrial fibrillation: a systematic review and meta-analysis. Journal of Interventional Cardiac Electrophysiology, 40(3):277-84. (Journal IF: 1.552; Citations: 0)

      Gewandter JS, Dworkin RH, Turk DC, McDermott MP, Baron R, Gastonguay MR, Gilron I, Katz NP, Metha C, Raja SN, Senn S, Taylor C, Cowan P, Desjardins P, Dimitrova R, Dionne R, Farrar JT, Hewitt DJ, Iyengar S, Jat GW, Kalso E, Kerns RD, LEff R, Leong M, Petersen KL, Ravina MB, Rauschkolb C, Rice ASC, Rowbotham MC, Sampaio C, Sindrup SH, Stauffer JW, Steigerwald I, Stewart J, Tobias J, Treede RD, Wallace3 M, White RE, (2014), Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations. Pain, 155(9): 1686-1695 (Journal IF: 5.836;  Citations: 3)

      Hill DLG, Scharwz AJ, Isaac M, Pani L, Vamvakas S, Hemmings R, Carrillo MC, Yu P, Sun J, Beckett L, Boccardi M, Brewer J, Brumfield M, Cantillon M, Cole PE, Fox N, Frisoni GB, Jack C, Kelleher T, Luo F, Novak G, MAguite P, Meibach R, Patterson P, Bain L, Sampaio C, Raunig D, Soares H, Suhy J, Wang HL, Wolz R, Stephenson D, (2014), Coalition against major diseases/European medicines agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer’ disease. Alzheimer’s and Dementia, (10)4: 421-429.  (Journal IF: 14.472; Citations: 1)

      Dodel R, Jonsson B, Reese JP, Winter Y, Martinez-Martin P, Holloway R, Sampaio C, Ruzicka E, Hawthorne G, Oertel W, Poewe W, Stebbins G, Rascol O, Goetz CG, Schrag A, (2014), Measurement of costs and scales for outcome evaluation in health economic studies of Parkinson´s disease. Movement Disorders, 29(2): 169-176. (Journal IF: 5.634; Citations: 2)

      Caldeira D, Loureiro MJ, Costa J, Pinto FJ, Ferreira JJ, (2014), Oral anticoagulation for pulmonary arterial hypertension: systematic review and meta-analysis. Canadian Journal of Cardiology, 30(8):879-87. (Journal IF: 3.940; Citations: 1)

      Caldeira D, Vaz-Carneiro A, Costa J, (2014), The impact of dosing frequency on medication adherence in chronic cardiovascular disease: Systematic review and meta-analysis.[Analysis of the Cochrane review: Anticoagulation versus placebo for heart failure in sinus rhythm. Cochrane Database Syst Rev. 2014;3:CD003336] Acta Med Port. 27(3):284-6. (Journal IF: 0.281; Citations: 0)

      Stout JC, Queller S, Baker KN, Cowlishaw S, Sampaio C, Fitzer-Attas C, Borowsky B, (2014), HD-CAB: a cognitive assessment battery for clinical trials in Huntigton’s disease 1,2,3. Movement Disorders, (29):6: 1281-1288. (Journal IF: 5.634; Citations: 1)

      Sampaio C, Borowsky B, Reilmann R, (2014) Clinical trials in Huntington´s Disease: interventions in early clinical development and newer methodological approaches. Movement Disorders, 29: (11): 1419-1428 (Journal IF: 5.634; Citations: 1)

      Azevedo P, Costa J, Vaz-Carneiro A, (2014) [Analysis of the Cochrane Review: Use of Systemic Corticosteroids for Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Cochrane Database Syst Rev. 2014, 9:CD001288]. Acta Med Port. 27(5):537-40. Acta Médica Portuguesa, 27(3):284-6. (Journal IF: 0.281; Citations: 0)

      Caldeira D, Costa J, Ferreira JJ, Pinto FJ, (2014), Net clinical benefit outcome should be standardized in trials evaluating antithrombotic drugs: the example of NOACs in atrial fibrillation. International Journal of Cardiology, 174(2):405-6. (Journal IF: 6.175; Citations: 0)

      Caldeira D, David C, Santos AT, Costa J, Pinto FJ, Ferreira JJ, (2014), Efficacy and safety of low molecular weight heparin in patients with mechanical heart valves: systematic review and meta-analysis. Journal of  Thrombosis Haemost, 12(5):650-9.(Journal IF: 5.550; Citations: 0)

      Caldeira D, Barra M, Santos AT, de Abreu D, Pinto FJ, Ferreira JJ, Costa J, (2014), Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysis. Heart, 100(7):550-6. (Journal IF: 13.857; Citations: 2)

      Cardoso AT, Nanji L, Costa J, Vaz-Carneiro A,  (2014) [Analysis of the Cochrane Review: Vitamin D supplementation for prevention of cancer in adults. Cochrane Database Syst Rev. 2014, 6:CD007469]. Acta Médica Portuguesa, 27(4):411-3.  (Journal IF: 0.281; Citations: 0)

      Caldeira D, Barra M, David C, Costa J, Ferreira JJ, Pinto FJ, (2014), The prevalence of oral anticoagulation in patients with atrial fibrillation in Portugal: Systematic review and meta-analysis of observational studies. Revista Portuguesa de Cardiologia, 33(9):555-560. (Journal IF: 0.525; Citations: 0)

      Caldeira D, Costa J, Pinto FJ, Ferreira JJ, (2014), The risk of infection with new oral anticoagulants: a meta-analysis. International journal of Cardiology, 72(1):267-8. (Journal IF: 6.175; Citations: 0)

      Sidiropoulos C, Masani K, Mestre T, Milosevic M, Poon YY, Fallis M, Shah BB, Kalia SK, Popovic MR, Lozano AM, Moro E, (2014) Spinal cord stimulation for gait impairment in spinocerebellar ataxia 7. Journal of Neurology, 261(3):570-574. (Journal IF: 3.578; Citations: 0)

      Neutel D, Biscoito L, Campos J, Melo TPE, Albuquerque L, (2014), Giant cell arteritis with symptomatic intracranial stenosis and endovascular treatment. Neurological Sciences, 35(4):609-610. (Journal IF: 1.412; Citations:  1)

      Lines M, Jobling R,  Brady L,  Marshall, CR,  Stephen W, Rodriguez  AR,  Lee L, Lang A,  Mestre T, Wanders R, Ferdinandusse S,   Tarnopolsky M, Canadian Pediatric Genetic Disorders Sequencing Consortium (FORGE Canada), (2014), Peroxisomal D-bifunctional protein deficiency: Three adults diagnosed by whole-exome sequencing. Neurology, 82 (11):63-8. (Journal IF: 8.249; Citations: 0)

      Hartling L, Vandermeer B, Fernandes RM, (2014), Systematic reviews, overviews of reviews and comparative effectiveness reviews: a discussion of approaches to knowledge synthesis. Evidence-Based Child Health: a Cochrane Review Journal, 9:486-494. (Journal IF: not indexed,  Citations:)

      Sousa R, Costa J, Vaz Carneiro A, Fernandes RM, (2014,) Cochrane Corner: Terapêutica combinada e alternada com paracetamol e ibuprofeno para crianças com febre. Acta Pediátrica Portuguesa, 2014; 45:64-66. (Journal IF: not indexed,  Citations:)

      Magalhães M, Costa J, Vaz Carneiro A, Fernandes RM, (2014) Cochrane Corner: overview de revisões sobre o tratamento da laringotraqueíte (CROUP). Acta Pediátrica Portuguesa, 2014; 45:168-171. (Journal IF: not indexed,  Citations:)

      Conceição I, Costa, J, Castro J, de Carvalho M, (2014), Invasive fibroblasts: Fundamental difference between sporadic inclusion body myositis and polymyositis, Muscle & Nerve, 49(2):181-186. (Journal IF: 2.314; Citations: 2)

      Luis L, Zhu H, Costa J, Valls-Solé J, Brandt T, Zhou W, Schneider E, (2014), Reply to the commentary on luis et Al. "Spontaneous plugging of the horizontal semicircular canal with reversible canal dysfunction and recovery of vestibular evoked myogenic potentials". Otology & Neurotology,35(2):379-83. (Journal impact factor: 1.598,  Citations: 0)

      Fernandes R, Hartling L, (2014), Glucocorticoids for Acute Viral Bronchiolitis in Infants and Young children, Jama, 311(1): 87-88. (Journal IF: 29.978, Citations: 0)

      Gil J, Costa J, Vaz Carneiro A, Fernandes RM,  (2014) Imuno-estimulantes na prevenção de infeções respiratórias em crianças. Acta Pediátrica Portuguesa, 2014; 45:253-255. (Journal IF: not indexed, Citations:

      Hartling L, Hamm MP, Fernandes RM, Dryden DM, Vandermeer B, (2014)  Quantifying Bias in Randomized Controlled Trials in Child Health: A Meta-Epidemiological Study. PLoS ONE, 9: 2. (Journal IF: 3.534, Citations: 1)

      Albuquerque L, Coelho M, Martins M, Guedes LC, Rosa MM, Ferreira JJ, Cattoni MB,  Carvalho H, Ferreira AG, Martins IP, (2014), STN-DBS does not change emotion recognition in advanced Parkinson's disease, Parkinsonism & Related Disorders, 20 (2): 166-169. (Journal IF: 3.274, Citations: 0)

      Conceição I, Costa J, Castro J, de Carvalho M, (2014), Neurophysiological techniques to detect early small-fiber dysfunction in transthyretin amyloid polyneuropathy. Muscle & Nerve, 49(2):181-6. (Journal IF: 2.314, Citations: 3)

      Vaz Carneiro A, Costa J. [Analysis of the Cochrane review: Multimedia educational interventions for consumers about prescribed and over-the-counter medications. Cochrane Database of Systematic Reviews 2013;4:CD008416]. Acta Médica Portuguesa: 4-5. (Journal IF: 0.281, Citations: 0)

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