Clinical Research in Non-communicable Neurological Diseases
The general aim of the José Ferro Lab is to study the clinical epidemiology of diseases involving the nervous system. The work of the research group focuses on large samples and on prevalent, disabling, chronic CNS conditions such as dementia, stroke and Parkinson's disease. Our aim is to identify risk factors, including ecological and genetic ones, and prognostic factors that lead from an independent life to dependency or death, as well as the development and assessment of therapeutic interventions capable of delaying or preventing the transition from a healthy, independent state to disability and death. Measures of disability will include neurophysiological and quality of life dimensions.
The large samples of patients afflicted with such chronic conditions will offer a unique opportunity for detailed neuropsychological and neuroimaging studies, as well as the development and testing of cognitive neuropsychological models.
The Principal Investigators (PIs) are involved in joint projects such as the study of prognosis of neglect in stroke patients, neurocognitive changes in Parkinson's disease, validation of several neuropsychological instruments and use of common Clinical Trial Section.
Research Team
Carolina Maruta
Clinical Researcher
Frederico Simões do Couto
Clinical Researcher
Gabriela Leal
Lab Technician
Research Areas
Clinical Neuropharmacology Group
Movement Disorders
Clinical trials
Drug Development
Pharmacoepedimiology
Cognitive Neuroscience Group
Illiteracy
Cognitive Neuroscience
Portuguese Sign Language
Stroke Group
Stroke
Vascular dementia / Vascular cognitive impairment
Neuropsychiatry, Neuropsychology of stroke
Cerebral venous thrombosis
Cardioembolic stroke
Dementia Group
Alzheimer's disease
Genomics of Complex Diseases Group
Genetics
Genomics
Stroke
Parkinson's disease
Sleep-eeg Group
Neurophysiology
Sleep
Epilepsy
Behavioural Neurology Group
Aphasia (in adults and childhood)
Memory and Dementia
Neglect
Recovery and recognition after brain lesions
Cognitive aspects of Epilepsy and DBS surgery
Pathology of Nervous System Group
Neuropathology of epilepsy surgery
Gliomas and glioneuronal tumours
Skin biopsies and polineurophaties
Obesity and muscle morphology
Ongoing Research Projects
2018/2021 Biomarcadores imagiológicos multimodais ao longo do ciclo da enxaqueca e tratamento preventivo personalizado por neurofeedback. Coordinator: Isabel Pavão Martins. Funding Agency: Fundação para a Ciência e a Tecnologia.
2016/2020 Randomised interventional prospective study of the effct of phsysical activity in vascular cognitive impairment. Coordinator: Ana Isabel Verdelho. Funding Agency: Fundação para a Ciência e a Tecnologia.
Selected Publications
Clinical Neuropharmacology Group
Emre M, Aarsland D, Alberto A., Byrne E J, Deuschl G, De Deyn Peter P, Durif F, Kulisevsky J, van Laar T, Lees A, M.D., Poewe W, Robillard A, Rosa MM, Wolters E, Quarg P, Tekin S, Lane R. (2004) Rivastigmine for Dementia Associated with Parkinson's Disease. N Engl J Med. 351(24): 2509-18.
Schrag A, Sampaio C, Counsell N, Poewe W. (2006) Minimal clinically important change on the unified Parkinson's disease rating scale. Mov Disord.; 21(8): 1200-7.
Costa J, Borges M, David C, Vaz-Carneiro A. (2006) Efficacy of Lipid-Lowering Drug Therapy for Diabetic and Non-Diabetic Patients: a Meta-analysis of Randomized, Controlled Trials. British Medical Journal; 13 (332): 1115-24.
Vellas B, Andrieu S, Sampaio C, Wilcock G (2007) European Task Force group. Disease-modifying trials in Alzheimer's disease: a European task force consensus. Lancet Neurol.;6(1): 56-62.
Silveira-Moriyama L, Guedes LC, Kingsbury A, Ayling H, Shaw K, Barbosa ER, Bonifati V, Quinn NP, Abou-Sleiman P, Wood NW, Petrie A, Sampaio C, Ferreira JJ, Holton J, Revesz T, Lees AJ. (2008) Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data. Neurology. 71(13): 1021-6.
Cognitive Neuroscience Group
Castro-Caldas, A., Miranda, P., Carmo, I., Reis, A., Leote, F., Ribeiro, C. & Ducla-Soares, E. (1999) Influence of learning to read and write on the morphology of the Corpus Callosum. European Journal of Neurology, 6: 23-28.
Petersson K.M., Reis A., AskelÖf S., Castro-Caldas A., Ingvar M. (2000) Language processing modulated by literacy: A network-analysis of verbal repetition in literate and illiterate subjects. J. Cognitive Neuroscience, 12: 364-382.
Martins IP, Castro-Caldas A, Townes BD, Ferreira G, Rodrigues P, Marques S, Rosebaum G, Benton TS, Leitao J, Derouen T.; (2005) Age and Sex Differences in Neurobehavioral Performance: A Study of Portuguese Elementary School Children; International Journal of Neuroscience, 115; 1687-1709.
DeRouen, T.; Martin, M.; Leroux, B.; Townes, B.; Leitão, J.; Woods, J.; Castro Caldas, A.; Luís, H.; Bernardo, M.; Rosenbaum, G.; Martins, I.; (2006) Neurobehavioral Effects of Dental Amalgam in Children: A Randomized Clinical Trial, JAMA, 295:15.
Rascol O, Dubois B, Castro-Caldas A, Senn S, Del Signore S, Lees A; (2006) Parkinson REGAIN Study Group Early piribedil monotherapy of Parkinson's disease: A planned seven-month report of the REGAIN study, Mov Disorders, Dec; 21: 2110-5.
Castro-Caldas A., Nunes MV., Maestú F., Ortiz T., Simões R., Fernandes R., La Guia E.,Garcia E., Gonçalves M, (2009) Learning orthography in adulthood: a magnetoencephalographic study; Journal of Neuropsychology, Volume 3, Part 1, p 17-30.
Stroke Group
Inzitari D, Simoni M, Pracucci G, Poggesi A, Basile AM, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Barkhof F, Visser MC, Wahlund LO, Waldemar G, Wallin A, Pantoni L; LADIS Study Group. (2007) Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study. Arch Intern Med 167: 81-88.
Bousser MG, Ferro JM.(2007) Cerebral venous thrombosis: an update.Lancet Neurol 6: 162-170.
Einhäupl K, Bousser MG, de Bruijn SF, Ferro JM, Martinelli I, Masuhr F, Stam J. (2006) EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol 13: 553-559.
Canhão P, Ferro JM, Lindgren AG, Bousser MG, Stam J, Barinagarrementeria F; ISCVT Investigators. (2005) Causes and predictors of death in cerebral venous thrombosis. Stroke 36: 1720-1725.
Pantoni L, Basile AM, Pracucci G, Asplund K, Bogousslavsky J, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, O'brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari D. (2005) Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology. Neuroepidemiology 24: 51-62.
Genomics of Complex Diseases Group
Oliveira SA, Li YJ, Noureddine MA, Züchner S, Qin XJ, Pericak-Vance MA, Vance JM. (2005) Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. American Journal of Human Genetics 77:252-64.
Oliveira SA, Scott WK, Zhang FY et al. (2004) Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype. Neurogenetics 5: 147-155.
Li Y-J, Oliveira SA, Xu P et al. (2003) Glutathione S-Transferase omega 1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Human Molecular Genetics 12:3259-3267.
Oliveira SA, Scott WK, Nance MA et al. (2003) Association study of Parkin gene polymorphisms with idiopathic Parkinson disease. Archives of Neurology 60:975-980.
Oliveira SA, Scott WK, Martin ER et al. (2003) Parkin mutations and susceptibility alleles in late-onset Parkinson disease. Annals of Neurology 53:624-629.
Sleep-eeg Group
Bentes C, Pimentel J, Costa J, Santos R, Rolo V. (2008) Ictal singing: case report and reappraisal of the literature. Epileptic Disorders, Vol. 10, Nº 2:113-118 .
Mestre T, Bentes C, Pimentel J. (2008) Ictal eructation: a case report. Epileptic Disorders. 10(2):170-2.
Behavioural Neurology Group
Martins, I.P., Gil-Gouveia, R., Antunes, J.L (2005). Double dissociation between autonomic symptoms and pain in cluster headache. Cephalagia, 25 (5), 389-400.
De, Rouen, T.A., Martin, M.D., Leroux, B.G., Townes, B.D., Woods, J.S., Leitao, J., Castro-Caldas, A., Luis, H., Bernardo, M., Rosenbaum, G., Martins, I.P. (2006). Neurobehavioral effects of dental amalgam in children: a randomized clinical trial. JAMA. 295 (15), 1784-9.
Martins, I.P., Gouveia, R.G., Parreira, E. (2006) Kinesiophobia in migraine. J Pain. Jun; 7 (6), 445-51.
Martins, I.P., Farrajota, L. (2007). Proper and common names: a double dissociation. Neuropsychologia, 45, 1744-1756.
Lauterbach, M., Martins, I.P., Garcia, P., Cabeça, J., Ferreira, A.C., Willmes, K. (2008) The Portuguese version of the Aachen Aphasia Test (AAT). Journal of the International Neuropsychological Society, 14, 1-11.