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Histology and Comparative Pathology Laboratory

The Histology and Comparative Pathology Laboratory aims to provide histology and comparative pathology support to iMM Lisboa scientists investigating animal models of human disease, and scientists/physicians investigating human disease. Services are also available for extramural investigators.

What is comparative medicine and pathology?
Comparative medicine and pathology are divisions of experimental medicine and pathology concerned with understanding phenomena integral to diseases of all species, including humans. Investigation focuses on both the similarities and differences between species and includes the development, validation, and utilisation of animal models (both naturally occurring and experimentally induced) to study the aetiology, pathogenesis, and treatment of human and veterinary disease. The discipline also includes the study of the normal biology of animals used as laboratory models.

Staff

Andreia Pinto (alpinto@medicina.ulisboa.pt)
Histotechnician
Ana Margarida Santos (anabsantos@medicina.ulisboa.pt)
Histotechnician

Services

RESEARCH HISTOLOGY
Processing, inclusion, sectioning and HE staining - paraffin; embedding and sectioning - cryostat
Histochemistry/special stains

IMMUNOHISTOCHEMISTRY
Protocol optimisation
Testing of antibodies on project tissue

TEM - transmission electron microscopy
Technique consulting and protocol optimisation
Sample processing for TEM and Immunolabeling
Semi- and Ultra-thin sectioning and grid counterstain
Visualisation and recording (equipment: Hitachi H-7650)

PATHOLOGIST SERVICES
Gross and microscopic examination with written reports and images
Assist in study design, Manuscript preparation & Grant submission

LASER CAPTION MICRODISECTION

Prices
Consult our price table.

How to use the service

  1. Cryostat utilisation requires booking online. Users must request booking permission online (induction/training required);
  2. Online requisition (link bellow) should be properly filled and submitted prior to sample delivery;
  3. Researchers will be notified by e-mail as soon as the work is complete, and should collect the slides at the lab; when the work is for pathology assessment the slides will be immediately re-directed to the pathologist (be sure to include all details regarding experimental setting and expected outcome of the pathology assessment in the request form or contact the pathologist).

Publications

Acknowledgements or Authorship
Manuscripts and grants presenting work supported by our lab should include the following acknowledgement:
"This work was supported by the Histology and Comparative Pathology Laboratory of the Instituto de Medicina Molecular."
Be sure to also provide us a copy of published reports.
Authorship is not mandatory but inclusion of the pathologist or histotechnician may be beneficial for the purposes of manuscript preparation and peer-review. Please consider authorship for the pathologist or histotechnician when our staff is significantly involved in experimental design and sample preparation, in generating a major portion of results and analysis, and/or in manuscript preparation. We thank you in advance for acknowledging our efforts and contributing to the future success of our laboratory!

More Information

Requisition form

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