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Employment Contract

Early Stage Researcher for Chemical site-selective functionalization of proteins with boronic acids

Open from 16 February 2016 to 29 February 2016

Boronic acids are unique chemical enteties with unmach reactivity for chemical synthesis and exibit unique stuctural features to be used as building blocks. Recognizing the potencial of these reagents for selective chemical protein modification, Shultz and co-workers have disclosed a seminal study in which p-boronophenylalanine was genetically encoded into proteins. In this project, we envisioned to perform the site-selective chemical incorporation of this functionality throug the use of suitable reagents that enable the formation of stable thioether ligations. This will be achieved using reaction of engineered cysteine residues with vinyl dipicolinic acid derivatives.

08 March 2016

Roberto Russo

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