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Veiga-Fernandes, Henrique
Lab

Lymphocyte Function & Development

The immune system is a key player in the resolution and prevention of severe pathologies, such as infectious and inflammatory diseases. To accomplish their function throughout life, immune cells interact with each other and with their external environment. Thus, all immune cell processes, ranging from haemotopoiesis to immune cell response to pathogens, require the establishment of effective cellular and molecular interactions. However, the mechanisms that underpin immune cell function and communication with their environment remain largely elusive.

In our lab we aim to explore novel communication pathways that determine immune cell fate and disease progression, focusing on haemotopoiesis and innate lymphoid cell development and function.

  • Research Areas

    • Lymphoid organogenesis
    • Haematopoiesis
    • Innate Lymphoid Cells
    • Mucosal Immunology
  • Research Team

    • Ongoing Research Projects

      • 2015/2020 ERC Consolidator Grant.
      • 2014/2017 Lymphoid Cell Function – CCFA, USA.
      • 2014/2015 Controlo of innate lymphoid cells and intestinal homeostasis by neurotrophic factors" - Breakthrough Award KRF.
      • 2013/2016 Control of intestinal homeostasis by innate lymphoid cells. FCT-ANR/IMI-IMU/0094/2012.
      • 2012/2015 Stromal Cell – Immune cell interactions in health and disease. STROMA.
    • Prizes

      • 2015 ERC Consolidator Grant.
      • 2014 Pfizer Prize Basic Science Pfzer/SCML, Portugal.
      • 2014 Senior Research Award, Crohn's and Colitis Foundation of America, USA.
      • 2014 Breakthrough Award, Kenneth Rainin Foundation, USA.
      • 2014 SPI Best Paper Award – "Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity".
      • 2014 EMBO Conference on Innate Lymphoid Cells, Paris, France - Best poster presentation.
      • 2014 SPI Mario Arala Chaves Immunology Excelence Award, Lisboa, Portugal - Best poster presentation.
      • 2013 SPI Best Paper Award - "Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems".
      • 2013 Innovator Awards Program, Kenneth Rainin Foundation, USA.
      • 2012 National Blood Foundation Fellow, USA.
      • 2009 Figuras do Futuro, Correio da Manhã.
      • 2008 ERC starting Grant.
      • 2008 EMBO Young Investigator Programme.
      • 2007 EMBO/ENII conference series, Cappo Caccia, Sardinia, Italy - Best poster presentation.
    • Selected Publications

      • Xu W., Domingues R. G., Fonseca-Pereira D., Ferreira M., Ribeiro H., Lopez-Lastra S., Motomura Y., Moreira-Santos L., Bihl F., Braud V., Kee B., Brady H., Coles M. C., Vosshenrich C., Kubo M., Di Santo J. P. and Veiga-Fernandes H. (2015) NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Reports, 10, 1-12.
      • Veldhoen M., Veiga-Fernandes, H. (2015) "Feeding immunity: skepticism, delicacies and delights". Nature Immunology 16, 215–219.
      • Fonseca-Pereira D., Arroz-Madeira S., Rodrigues-Campos M., Barbosa I. A., Domingues R. G., Bento T., Almeida A. R., Ribeiro H., Potocnik A. J., Enomoto H., Veiga-Fernandes, H. (2014) "The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function". Nature, 514, 98-101.
      • van de Pavert, S.A., Ferreira, M., Domingues, R.G., Ribeiro, H., Molenaar R., Moreira-Santos L., Almeida, F.F., Ibiza, S., Barbosa I., Goverse, G., Labão-Almeida C., Godinho-Silva, C., Konijn, T., Schooneman, D., O'Toole, T., Mizee, M.R., Habani, Y., Haak. E., Santori F.R., Littman D.R., Schulte-Merker S., Dzierzak, E., Simas, J.P., E. Mebius, R., Veiga-Fernandes, H. (2014) Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity. Nature 508,123–127.
      • Klose C.S., Flach M., Möhle L., Rogell L., Hoyler T., Ebert K., Fabiunke C., Pfeifer D., Sexl V., Fonseca-Pereira D., Domingues R.G., Veiga-Fernandes H., Arnold S.J., Busslinger M., Dunay I.R., Tanriver Y., Diefenbach A. (2014) Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages. Cell 157(2):340-56.
      • Patel A., Harker N., Moreira-Santos L., Ferreira M., Alden K., Timmis J., Foster K., Garefalaki A., Pachnis P., Andrews P. Enomoto H., Milbrandt J., Pachnis V., Coles M. C., Kioussis D., Veiga-Fernandes H. (2012) Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems. Sci. Signal. 5, ra55.
      • Veiga-Fernandes H., Kioussis D., Coles M. (2010) Natural killer receptors: the burden of a name. J Exp Med. 207(2): 269-72.
      • Veiga-Fernandes H., Coles M.C., Foster K.E., Patel A., Williams A., Natarajan D., Barlow A., Pachnis V., Kioussis D. (2007) Tyrosine kinase receptor Ret is a key regulator in Peyer's Patch organogenesis. Nature, 446: 547-51.
      • Peixoto A., Evaristo C., Munitic I., Monteiro M., Charbit A., Rocha B., Veiga-Fernandes H. (2007) CD8 single-cell co-expression reveals three different effector types present at distinct phases of the immune response. J. Exp. Med., 204: 1193-1205.
      • Veiga-Fernandes H. and Rocha B. (2004) High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division. Nature Immunology, 5: 31-37.
      • Veiga-Fernandes H., Walter U., Bourgeois C., McLean A., Rocha B. (2000) Response of naive and memory CD8+ T cells to antigen stimulation in vivo. Nature Immunology, 1: 47-53.

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