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Remondes, Miguel

Neural Mechanisms of Perception, Memory & Decision

Explaining how billions of neurons connected trillions of times generate mental functions remains one of the greatest tasks sciences face today. Declarative memory involves the association and storage of information from distinct brain regions, orchestrated by a medial temporal structure called the hippocampus, through a mechanism called activity-dependent neural plasticity. Disruption of such mechanism leads to socially pervasive mental dysfunctions. Scientists have investigated the physiology of memory circuits, but less so the way these circuits integrate incoming sensory information, or govern the use of memory for other brain functions. In addition, until recently we lacked the technology to adequately address causality between physiology and behavior. Neural recordings, combined with the recently-developed technique of optogenetics, promises to change this scenario, provided tissue and neuron specificity is improved.

In my lab I jointly develop neural recordings and optogenetics, neural manipulation achieved by light-activation of membrane channels, to investigate mechanistically the neural processing of sensory information, and the way this information is transferred within the brain, in the awake-behaving rodent.

This knowledge will eventually be applied to explain the bases of neurological and psychiatric disease.

  • Research Areas

    • Neurophysiology
    • Optogenetics
    • Hippocampus
    • Cortex
    • Cingulate
    • Retrosplenial
    • Entorhinal
    • Single- neuron
    • Recordings
    • Awake-behaving
    • Sleep
    • Decison
    • Choice
    • Coding
    • Spatial context
  • Research Team

    • Ongoing Research Projects

      • FCT Investigator IF/00201/2013 - The neural basis of memory and decision-making
    • Prizes

      • 2013 FCT Investigator Grant – PI at IMM - University of Lisbon Medical School.
      • 2005 Postdoctoral fellowship from FCT-Portugal
      • 1999 Doctoral fellowship from FCT-Portugal, within the Gulbenkian Ph.D. Program in Biology and Medicine
      • Graduation Awards by the Portuguese Society for Veterinary Sciences:
      • 1993 Bernardo Lima Award for outstanding academic achievements in the areas of: Biomathematics, Genetics and Economics
      • 1993 Ildefonso Borges Award for outstanding academic achievements in the areas of: Parasitology and Parasitic Diseases
      • 1993 Ferreira Lapa Award for outstanding academic achievements in the areas of: Biochemistry, Microbiology and Immunology
    • Selected Publications

      • Wilson M, Varela C* and Remondes M * (2014) Phase regulation of limbic networks, Current Opinions in Neurobiology (invited review, in preparation for a special issue on "Brain rhythms and dynamic coordination").
      • Remondes M * and Wilson M (2014) Slow-gamma rhythms coordinate cingulate cortical responses to hippocampal sharp-wave ripples during choice behavior (under peer-review at Neuron).
      • Remondes M * and Wilson M (2013) Cingulate-Hippocampus Coherence and Trajectory Coding in a Sequential Choice Task, Neuron, 80(5), 1277-1289.
      • Remondes M and Schuman E M (2004) Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory, Nature 431, 699-703.
      • Remondes M and Schuman E M (2003) Molecular Mechanisms Contributing to Long-Lasting Synaptic Plasticity at the Temporoammonic-CA1 Synapse, Learning and Memory 10, 247-252
      • Remondes M and Schuman E M (2002) Modulation of Plasticity and Spiking in CA1 Pyramidal Neurons by a Direct Cortical Input, Nature 416, 736-740.

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