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Prudêncio, Miguel
Lab

Plasmodium Infection & Anti-malarial Interventions

Our lab's research interests span a wide range of topics within the malaria field, with particular emphasis on the hepatic stage of infection. We are interested in elucidating hitherto obscure aspects of the biology of Plasmodium infection, unveiling novel host-parasite interactions, and developing new drug- and vaccine-based anti-malarial strategies.

  • Research Areas

    • Understanding the molecular mechanisms of nutrient and ion transport and homeostasis during Plasmodium development inside hepatic cells.
    • Elucidating the role of bile acid metabolism and nuclear receptor-mediated signaling mechanisms in the context of Plasmodium liver infection.
    • Evaluating novel compounds in terms of their efficacy against Plasmodium liver stages.
    • Developing a novel pre-erythrocytic whole-organism, multi-stage anti-malarial vaccination strategy.
    • Investigating the reciprocal influence of Plasmodium and Trypanosoma co-infections.
  • Research Team

    • Ongoing Research Projects

      • 2010/2015 "A new whole-organism vaccine against Malaria". Grand Challenges Explorations (Phase II), Bill & Melinda Gates Foundation. Coordinator: Miguel Prudêncio, 1.218.000 USD
      • 2012/2015 "Utilization of host cell resources by the malaria parasite in the liver". Fundação para a Ciência e Tecnologia, Portugal. Coordinator: Miguel Prudêncio. PTDC/SAU-MIC/117060/2010, 154.755 €
      • 2012/2015 "Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle". Fundação para a Ciência e Tecnologia, Portugal. Co-PI: Miguel Prudêncio. Collaboration with Lisbon Pharmacy School (FFUL, Coordinator: Francisca Lopes). PTDC/SAU-FAR/118459/2010, 132.000 € (36.241€ for IMM)
    • Prizes

      • 2014 - EVERIS Entrepreneurs Award, Grand Finalist, April 2014, Madrid, Spain
      • 2013 - National BES Innovation Contest, 1st Prize for the Health Track and Winner of the Grand Prize, Concurso Nacional de Inovação do Banco Espirito Santo, November 2013, Lisboa, Portugal
      • 2013 - Building Global Innovators - ISCTE-IUL MIT-Portugal Venture Competition, Honorary Mention Health Track, November 2013, Lisboa, Portugal
      • 2008 - Amélia da Silva de Mello Award for Health Sciences, 1st Prize for the work entitled "Host SR-BI plays a dual role in the establishment of malaria liver infection", José de Mello ▪ Saúde, September 2008, Lisboa, Portugal
      • 2007 - CESPU International Research Award, 1st Prize for the work entitled "SR-BI plays a dual role in the establishment of malaria liver infection", Cooperativa de Ensino Superior Politécnico e Universitário, November 2007, Porto, Portugal
      • 2004 - Marie Curie Reintegration Grant
      • 2001 - Marie Curie Fellowship
    • Selected Publications

      • M.D. Lewis, J. Behrends, C.S. Cunha, A.M. Mendes, F. Lasitschka, K. Heiss, T.W.A. Kooij, M.Prudêncio, F.Frischknecht and A.-K. Mueller (2015), "Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression", Journal of Immunology, in press
      • C.A.B. Rodrigues, R.F.M. Frade, I.S. Albuquerque, M.J. Perry, J. Gut, M. Machado, P.J. Rosenthal, M. Prudêncio, C.A.M. Afonso, R. Moreira (2015), "Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s-Triazine-Based Hybrids", ChemMedChem, in press
      • P. Liehl*, P. Meireles*, I.S. Albuquerque, M. Pinkevych, F. Baptista, M.M. Mota, M.P. Davenport, M. Prudêncio (2015), "Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections", Infection and Immunity, 83, 1172-1180. *Equally contributing authors
      • P. Liehl, V. Zuzarte-Luís, J. Chan, T. Zillinger, F. Baptista, D.l Carapau, M. Konert, K. Hanson, C. Carret, C. Lassnig, M. Müller, U. Kalinke, M. Saeed, A.F. Chora, D.T. Golenbock, B. Strobl, M. Prudêncio, L.P. Coelho, S.H. Kappe, G. Superti-Furga, A. Pichlmair, A.M. Vigário, C.M. Rice, K.A. Fitzgerald, W. Barchet, M.M. Mota (2014) "Host cell sensors for Plasmodium activate innate immunity against liver stage infection", Nat. Med., 20, 47-53.
      • T. Rodrigues, F.P. da Cruz, M. Lafuente-Monasterio, D. Gonçalves, A. Ressurreição, A.R. Sitoe, M.R. Bronze, J.Gut, G. Schneider, M.M. Mota, P.J. Rosenthal, M. Prudêncio, F.-J. Gamo, F. Lopes, R. Moreira (2013) "Quinolon-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria", J. Med. Chem., 56, 4811-4815.
      • E. Dempsey, M. Prudêncio, B.J. Fennell, C.S. Gomes-Santos, J.W. Barlow, A. Bell (2013) "Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites", Mol. Biochem. Parasitol., 188, 116-127. Highlighted as Feature Article on Malaria Nexus
      • J. Lin, P. Meireles, M. Prudêncio, S. Engelmann, T. Annoura, M. Sajid, S. Chevalley‐Maurel, J. Ramesar, C. Nahar, C.M.C. Avramut, A.J. Koster, K. Matuschewski, A.P. Waters, C.J. Janse, G.R. Mair, S.M. Khan (2013) "Loss‐of‐Function Analyses Defines Vital and Redundant Functions of the Plasmodium Rhomboid Protease Family", Mol. Microbiol., 88, 318-338.
      • B.C. Pérez, C. Teixeira, I.S. Albuquerque, J. Gut, P.J. Rosenthal, J.R.B. Gomes, M. Prudêncio, P. Gomes (2013) "N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads", J. Med. Chem., 56, 556-567.
      • M. Prudêncio, Maria M. Mota (2013) "Targeting host factors to circumvent anti-malarial drug resistance", Curr. Pharm. Des., 19, 290-299.
      • F.P. da Cruz, C. Martin, K. Buchholz K, M.J. Lafuente-Monasterio, T. Rodrigues, B. Sönnichsen, R. Moreira, F.J. Gamo, M. Marti, M.M. Mota, M. Hannus, M. Prudêncio (2012) "Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multi-Stage Anti-Malarial Drug", J. Inf. Dis., 205, 1278-1286, Evaluated by Faculty of 1000 Biology and Medicine
      • M. Prudêncio, M.M. Mota, A.M. Mendes (2011) "A toolbox to study liver stage malaria", Trends Parasitol., 27, 565-574 (Review), Selected by MalariaNexus
      • R. Capela, G.G. Cabal, P.J. Rosenthal, J. Gut, M.M. Mota, R. Moreira, F. Lopes, M. Prudêncio (2011) "Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy", Antimicrob. Agents Chemother., 55, 4698-4706.
      • K. Slavic, M.J. Delves, M. Prudêncio, A.M. Talman, U. Straschil, E.T. Derbyshire, Z. Xu, R.E. Sinden, M.M. Mota, C. Morin, R. Tewari, S. Krishna, H.M. Staines (2011) "Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite's Life Cycle", Antimicrob. Agents Chemother., 55, 2824-2830.
      • I.H. Ploemen, M. Prudêncio, B.G. Douradinha, J. Ramesar, J. Fonager, G.J. van Gemert, A.J. Luty, C.C. Hermsen, R.W. Sauerwein, F.G. Baptista, M.M. Mota, A.P. Waters, I. Que, C.W. Lowik, S.M. Khan, C.J Janse, B.M. Franke-Fayard (2009) "Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging", PLoS ONE, 4, e7881.
      • M. Prudêncio, E.T. Derbyshire, C.A. Marques, S. Krishna, M.M. Mota, H.M. Staines (2009) "Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells", Cell. Microbiol., 11, 1492-1501.
      • M. Prudêncio, M.J. Lehmann (2009) "Illuminating the host - How RNAi screens shed light on host-pathogen interactions", Biotechnol. J., 4, 826-837.
      • M. Prudêncio, C.D. Rodrigues, M. Hannus, C. Martin, E. Real, L .A. Gonçalves, C. Carret, R. Dorkin, I. Röhl, K. Jahn-Hoffmann, A.J.F. Luty, R. Sauerwein, C.J. Echeverri, M.M. Mota (2008) "Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection", PLoS Pathogens, 4, 1-15.
      • C.D. Rodrigues, M. Hannus, M. Prudêncio, C. Martin, L.A. Gonçalves, S. Portugal, S. Epiphanio, A. Akinc, P. Hadwiger, K. Jahn-Hofmann, I. Röhl, G.J. van Gemert, J.F. Franetich, A.J. Luty, R. Sauerwein, D. Mazier, V. Koteliansky, H.P. Vornlocher, C.J. Echeverri, M.M. Mota (2008) "Host Scavenger Receptor SR-BI Plays a Dual Role in the Establishment of Malaria Parasite Liver Infection", Cell Host & Microbe, 11, 4, 271-282.
      • O. Silvie, M.M. Mota, K. Matuschewski, M. Prudêncio (2008) "Interactions of the malaria parasite and its mammalian host", Curr. Opin. Microbiol., 11, 352-359.
      • M. Prudêncio, C.D. Rodrigues, R. Ataíde, M.M. Mota (2008), "Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry", Cell. Microbiol., 10, 218-224.
      • M. Prudêncio, M.M. Mota (2007), "To migrate or to invade: those are the options", Cell Host & Microbe, 2, 286-288.
      • M. Prudêncio, A. Rodriguez, M.M. Mota (2006), "The silent path to thousands of merozoites: the Plasmodium liver stage", Nat. Rev. Microbiol., 2006, 4, 849-856.

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