pt en

Lopes, Luísa V.

Neurobiology of Ageing & Disease

Ageing, stress and neurodegenerative diseases are among the conditions that contribute to the accelerated loss of cognitive function. Our group's work is focused on understanding the mechanisms inducing this "early-ageing", which render the hippocampus - the brain area related to learning and memory – particularly susceptible.

We focus on characterizing the molecular mechanisms associated to hippocampal loss of function and its outcome in behavior performance and synaptic function, using rodent models. We ensure the translation to the human brain, by testing these molecular imprints in healthy and diseased human brain tissue. We are currently focused into exploring the role of adenosine A2A receptors as potential cognitive modulators both in vitro and in vivo.

Aging - Stress – Hippocampus - Neurodegenerative diseases - Memory

  • Research Areas

    • Molecular switches from aging towards neurodegeneration in the hippocampus
    • Impact of circadian modulation on hippocampal-dependent memory
    • Therapeutic actions of caffeine and caffeine analogs against memory deficits
    • Cognitive dysfunction in Alzheimer's mouse models
    • Molecular mechanisms of early cognitive deficits in Parkinson's disease
  • Research Team

    • Ongoing Research Projects

      FCT 2016-2019 - Microglia dysregulation as trigger for chronic brain inflammation

      FCT 2016-2019 - Targeting the glycation defenses as a protective strategy for Parkinson’s disease

      AIRR 2016-2018 -  Actions d’Initiative Régionale pour la Recherche; France  -   "Role neuro-glial des récepteurs adénosinergiques dans la cognition"

      H2020 Twinning action SynaNet 2016-2019  “Neurologic and Psychiatric Disorders: from synapses to networks”

    • Prizes

      • 2013 - ISN Meeting Award
      • 2012 - Investigator FCT,  Fundação para a Ciência e Tecnologia, Portugal

      • 2012 - EMBO fellowship (to PhD student: Vânia Batalha): Epigenetics as the mechanism underlying hippocampal deficits induced by stress.

      • 2010 - BIAL Foundation - “Psychological indicators of stress reactivity and disease adaptation”
      • 2010 - Dana Alliance Foundation - “What goes on in your mind?” - Brain Awareness Week 2010
      • 2008 - Ciência 2007 award. Fundação para a Ciência e Tecnologia, Portugal
      • 2001 - FEBS (Federation of European Biochemical Societies) 
      • 2000 –Trends in Neuroscience (TINS) publication award
      • 1999 - FEBS (Federation of European Biochemical Societies)
    • Selected Publications

      • Diana G. Ferreira, Mariana Temido-Ferreira, Hugo Vicente Miranda, Vânia L. Batalha, Joana E. Coelho, Éva M. Szegö, Inês Marques-Morgado, Sandra H. Vaz, Jeong Seop Rhee, Matthias Schmitz, Inga Zerr, Luísa V. Lopes* and Tiago F. Outeiro* (2017) α-Synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B. Nature Neuroscience doi: 10.1038/nn.4648 *co-senior author
      • Vicente Miranda H, Szego ÉM, Oliveira LM, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF (2017) Glycation potentiates a-synuclein-associated neurodegeneration in synucleinopathies Brain. 2017 Apr 10. doi: 10.1093/brain/awx056.
      • VL. Batalha, DG. Ferreira, JE. Coelho, JS. Valadas, R Gomes, MT emido-Ferreira, T Shmidt, Y Baqi, L Buée, CE. Müller, M Hamdane, TF. Outeiro, M. Bader, SH. Meijsing, G Sadri-Vakili, D Blum, and Luísa V. Lopes (2016) The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Scientific Reports,1;6:31493. doi: 10.1038/srep31493.
      • Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonçalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV (2015)  Adenosine A2A Receptors Modulate a-Synuclein Aggregation and Toxicity. Cereb Cortex.2015 Nov 2. pii: bhv268.
      • C. Laurent, S. Burnouf, B.  Ferry, VL. Batalha, JE. Coelho, Y Baqi, E. Malik, E. Mariciniak, S. Parrot, A. Van der Jeugd, E. Faivre, V. Flaten, C. Ledent, R. DHooge, N. Sergeant, M. Hamdane, S. Humez, CE. Muller, Luisa V. Lopes, L. Buee, D. Blum (2014) A2A adenosine receptor deletion is protective in a mouse model of Alzheimer disease. Mol. Psychiatry, doi: 10.1038/mp.2014.151
      • Coelho JE, Alves P, Canas PM, Valadas JS, Shmidt T, Batalha VL, Ferreira DG, Ribeiro JA, Bader M, Cunha RA, do Couto FS, Lopes LV (2014) Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety. Front Psychiatry. 2014 doi: 10.3389/fpsyt.2014.00067.
      • VL. Batalha, JM. Pego B Fontinha, AR Costenla, J Valadas, Y Baqi, H Radjainia, C E. Müller, AM. Sebastião and Luísa V. Lopes (2013) Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation. Mol. Psychiatry18, 320-331  
      • MJ Diógenes, RB. Dias, DM. Rombo, H Vicente Miranda, F Maiolino, P Guerreiro, T Nasstrom, HG. Sebastião, Luísa V. Lopes and TF Outeiro (2012) Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. J. Neurosci. 32:11750-11762.
      • Chen JF, Sonsalla PK, Pedata F, Melani A, Domenici MR, Popoli P, Geiger J, Lopes LV, de Mendonça (2007) Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog. Neurobiol83, 310-31
      • Trevor W. Stone, Herbert Zimmermann, Luísa V. Lopes & Marloes P. Schaddelee (2001) Purines in Portugal. Trends Neurosci., 24, 629-630

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