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Gomes, Edgar
Lab

Cell Architecture
 Master Thesis Project Proposals:

Connecting the nucleus to the cytoskeleton is relevant for multiple cellular processes and disruption of these connections result in multiple pathologies. Nuclear positioning within cell cytoplasm requires de connection between nucleus and the cytoskeleton. We are interesting to understand the processes involved in these connections and the role for nuclear positioning in cell function.

We study cell migration and skeletal myofiber formation which required the connection between the nucleus and the cytoskeleton and precise nuclear positioning. We use different molecular and cellular approaches in combination with time-lapse imaging analysis to address these questions.

 

  • Research Areas

    • Mechanisms of nuclear movement during cell migration and skeletal muscle formation
    • Role for nuclear positioning in skeletal muscle formation
  • Research Team

    • Ongoing Research Projects

      2016-2018: ERC proof of concept Grant

      2016-2019: Coordinator of H2020-TWINN-2015 Cancer Biology consortium 

      2014-2019: ERC Consolidator Grant

      2014-2019: EMBO Installation Grant

      2014:2019: Investigador FCT

    • Prizes

    • Selected Publications

      • D’Alessandro, M., Hnia, K., Gache, V., Koch, C., Gavriilidis, C., Rodriguez, D., Nicot, A.-S., Romero, N.B., Schwab, Y., Gomes, E.R., Labouesse, M., Laporte, J. (2015). Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton. Developmental Cell35, 186–198.
         
      • Sestina Falcone, William Roman, Karim Hnia, Vincent Gache, Nathalie Didier, Jeanne Lainé, Frederic Aurade, Isabelle Marty, Ichizo Nishino, Nicolas Charlet-Berguerand, Norma Romero, Giovanna Marazzi, David Sassoon, Jocelyn Laporte, Edgar R. Gomes. N-WASP is required for Amphiphysin-2/BIN1 dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy. EMBO Mol Med 6, 1455–1475 (2014) (PDF)

      • Metzger, T., Gache, V., Xu, M., Cadot, B., Folker, E., Richardson, B., Gomes, E.R.*, Baylies, M.K.*. MAP and Kinesin dependent nuclear positioning is required for skeletal muscle function. Nature 484, 120–124 (2012), *co-last and corresponding author

      • Cadot, B., Gache, V., Vazyutina, E., Falcone, S., Birchmeier, C., Gomes. E.R. Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3. EMBO Reports, 13(8):741-9 (2012)
      • Borrego-Pinto, J., Jegou, T., Osorio, D., Aurade, F., Gorjánácz, M., Koch, B., Mattaj, I., and Gomes, E. R. (2011). Samp1 is a new component of the TAN lines and is required for nuclear movement. Journal of Cell Science, 125, 1099–105 (2012)
      • Luxton GW*, Gomes ER*, Folker ES, Vintinner E, Gundersen GG. Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science. 2010 Aug 20;329(5994):956-9.
        *co-first author
      • E.R. Gomes, S. Jani, G.G. Gundersen "Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells ", Cell, 2005, 121: 451-63

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