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De Carvalho, Mamede
Lab

Translational Clinical Physiology

This lab was formed by the merging of the previous Neuromuscular and Autonomic Nervous System Units, in order to establish a larger Unit interested in animal and human physiology studies. This Unit integrated some scientifically active members working in the Physiology Institute of the Faculty of Medicine-University of Lisbon. Prof Tiago Maia joined our group, adding behaviour and imaging-neurocomputational models of brain dysfunction as a new area of scientific development in our Unit.

We aim to increase our potential to investigate areas as the autonomic nervous system and cardiovascular regulation, motor neuron and peripheral nerve physiology, behavior and imaging-neurocomputational models of brain dysfunction. We plan to implement a translational, multi-methodological approach to neuromuscular and brain diseases, using animal models, clinical neurophysiology, neurocomputational models, brain imaging and neuropsychological experimentation. We target to approach both function and mechanisms of dysfunction by investigating specific disorders. In particular, we are interested in the following diseases: Tourette's syndrome and conflict adaptation; amyotrophic lateral sclerosis and familial amyloid polyneuropathy; atrial fibrillation, neurogenic hypertension and neurocardiogenic syncope.

  • Research Areas

    • Amyotrophic Lateral Sclerosis, neurophysiology and respiratory involvement.
    • Familial Amyloid Polyneuropathy and early markers of disease.
    • Transcranial magnetic stimulation, motor excitability and caffeine.
    • Nerve Excitability
    • Atrial Fibrillation and autonomic nervous system.
    • Neurogenic hypertension.
    • Neurocardiogenic syncope.
    • Biological signal processing
    • Diaphragm pacing.
    • Integrated neuroimaging
    • Neurocomputational modelling of brain disorders
    • Tourette's syndrome
    • Obsessive-Compulsive Disorder
    • Attention deficit hyperactivity disorder
  • Research Team

    • Ongoing Research Projects

      • 2007/2012 Respiratory Rehabilitation in Amyotrophic Lateral Sclerosis: Clinical and Biochemical Impact. FCT., Coordinator: M.de Carvalho. (PIC/IC/82765/2007).
      • 2008/2012 Prevalence and severity of fatty liver in morbid obesity: correlation and mechanisms related to the role of ectopic fat in insulin resistance , FCT, Coordinator: H.Cortez-Pinto. (PTDC/SAU- OSM/100878/2008).
      • 2008/2018 Transthyretin-associated amyloidoses outcomes survey (THAOS). A Global, Multi-Center, Longitudinal, Observational Survey of Patients with Documented Transthyretin (TTR) Mutations or Wild-Type TTR Amyloidosis, Pfizer/FoldRx Pharmaceuticals, Inc. – Scientific Board Member, Coordinator: I Conceição
      • 2009/2011 Autonomic nervous system influences on renal stone diasease. FCT, Coordinator: I.Rocha, PIC/IC/83243/2007.
      • 2009/2011 Complement polymorphism analyses in FAP type I populations. To test for correlation between polymorphisms in C1QA , with age of onset in Portuguese, Greek and further Cypriot patients with FAP type I, Coordinator: M.J Saraiva
      • 2009/2012 Caracterização Clínica e Diagnóstica de Doentes com Patologia Neuromuscular - Estudo Epidemiológico em Portugal (ENDOMUS). (Sociedade Portuguesa de Estudos de Doenças Neuromusculares (SPEDNM). Coordinator: T. Evangelista
      • 2009/2012 MUNIX - Multicentric International study to evaluate a new method for motor unit number estimation. Coordinator: M. Weber
      • 2009/2013 Awaji criteria validation. This is an international project to test sensitivity and specificity of Awaji criteria for ALS. Coordinator: M. de Carvalho (no current funding).
      • 2010/2011 Open-Label Safety Evaluation of Fx-1006A in Patients with Transthyretin Amyloidosis. Pfizer/FoldRx Pharmaceuticals, Inc., Coordinator: I. Conceição.
      • 2010/2013 Wi-CardioResp, Sistema Integrado para Monitorização em Ambulatório de Parâmetros Cardio-Respiratórios. Entidade financiadora PLUX e Co-Promoção do QREN, aviso nº 16/SI/2009, Coordinator: H. Gamboa.
      • 2010/2013 Construção de um Pacemaker Diafragmático a ser testado em rato com vista a ser aplicado no ser humano com insuficiência respiratória. FCT, Coordinator: I. Rocha , PTDC/EEA-ELC/109083/2008.
      • 2010/2013 Modificação genética das células do núcleo paraventricular do hipotálamo (PVN) e medula rostroventrolateral (RVLM) para controlar cronicamente a hipertensão. FCT, Coordinator: I Rocha, PTDC/SAU-OSM/109081/2008.
      • 2010/2012 A influência dos ácidos biliares na infecção do figado por malária, Coordinator: I. Rocha, PTDC/SAU-MII/099118/2008.
      • 2010/2012 On the role of VIP receptors in hippocampal dependent cognition and synaptic plasticity: evaluation of the therapeutic potential of VPAC1 receptor antagonists to ameliorate the cognitive deficits in TLE. FCT, Coodinator: Diana Cunha Reis, PTDC/SAU-NEU/103639/2008.
      • 2011/2012 Autorregulação no acidente vascular cerebral agudo. FCT, Coordinator: I Rocha , PTDC/SAU-ORG/113329/2009.
      • 2011/2012 Estudo do Cito-Esqueleto Neuronal em Neuropatias de Pequenas Fibras: Reconstrução Tridimensional de Imagens de Alta Resolução com a Utilização de Quantum Dots. Coordinator: P Pereira, M de Carvalho
      • 2011/2012 Fx1A-303 – Open-Label Safety and Efficacy Evaluation os Fx-1006ª in Patients with Transthyretin Amyloidosis. Pfizer/FoldRx Pharmaceuticals, Inc., Coordinator: I. Conceição.
      • 2011/2013 Estudo do impacto das Tecnologias de Apoio à Comunicação nos Doentes com ela e respectivos cuidadores, FCG Fundação Calouste-Gulbenkian, Coordinator: M. de Carvalho.
      • 2011/2014 Understanding Neurodegenerative Diseases Through Clinical and OMICS data Integration-Neuroclinomics – Neuroclinomics, FCT, Coordinator: S. Madeira (PTDC/EIA-EIA/111239/2009).
      • 2011/2013 Reinforcement learning and motor biases in children with Tourette syndrome. Tourette Syndrome Association. Coordinator: T. V. Maia.
      • 2012/2015 SOPHIA: Sampling and biomarker Optimization and Harmonization In ALS and other motor neuron diseases (Joint Program Neurodegenerative Disease). Coordinator: L van den Bergh.
    • Prizes

      • 2011/2012 Award of Best Communication in Lisbon Arrhythmia Meeting with the work entitled "Changes in ion channel and connexin gene expression induced by autonomic stimulation: potential interactions with atrial remodeling?"( awarded to Mário Oliveira)
      • 2011/2012 Jorge Quininha Awards for the following publications: "Acute Vagal Modulation of Electrophysiology of the pulmonary veins and atrial vulnerability to atrial fibrillation power increase", "Effects of acute autonomic modulation on atrial conduction delay and local electrograms duration in paroxysmal atrial fibrillation" and" Defining left bundle branch block in the era of cardiac Resynchronization therapy ". (awarded to Mário Oliveira)
      • 2011 Clinical Research Fellowship in Neuromuscular Diseases awarded by the Portuguese Society of Neurology with the work entitled "Study of Neuronal Cito skeleton of Small Fiber in Neuropathies - Three Dimensional Reconstruction of high-resolution images with the use of Quantum Dots", Pedro Pereira and Mamede de Carvalho
      • 2008 1st Prize Corino de Andrade-Novartis da Sociedade Portuguesa de Neurologia, for the paper "Predictive Value of the Respiratory Function Tests for Detecting Hypoventilation in Amyotrophic Lateral Sclerosis" (awarded Susana Pinto; Anabela Pinto; Mamede de Carvalho)
    • Selected Publications

      • Pato MP, Santos NJG, Areias P, Pires, EB, de Carvalho M, Pinto, S, Lopes, DS (2011) "Finite element studies of the mechanical behavior of the diaphragm in normal and pathological cases". Comput Methods Biomech Biomed Engin; 14, 505-513 (Journal IF: 1.566).
      • de Carvalho M (2011) "The needle goes deeper in ALS". Clin Neurophysiol (Editorial); 122, 414-422 (Journal IF: 2.786).
      • de Carvalho M, Pinto S, Swash M (2011) " Does the motor cortex influence denervation in ALS? EMG studies of muscles with both contralateral and bilateral corticospinal innervations". Clin Neurophysiol; 122, 629-635 (Journal IF: 2.786, Citations: 2).
      • de Carvalho M, (2011) "Deep Thoughts in ALS". Clin Neurophysiol (Editorial); 122, 845-846 (Journal IF: 2.786).
      • de Carvalho M, Swash M (2011) "Fasciculation-cramp syndrome preceding anterior horn cell disease: an intermediate syndrome? "J Neurol Neurosurg Psychiatry; 82, 459-461. (Journal IF: 4.791 Citations: 3).
      • Lee T, Li YR, Ingre C, Weber M, Grehl T, Gredal O, de Carvalho M, Meyer T, Tysnes OB, Auburger G, Gispert S, Bonini NM, Andersen PM, Gitler AD, (2011) "Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients". Hum Mol Genet; 20, 1697-1700. (Journal IF 8.058).
      • de Carvalho M, (2011) "Why is ALS so excited?" Clin Neurophysiol (Editorial); 122, 1689-1690. (Journal IF: 2.786).
      • Neuwirth C, Nandedkar S, Stalberg E, Barkhaus PE, de Carvalho M, Furtula J, van Dijk JP, Baldinger R, Castro J, Costa J, Otto M, Sandberg A, Weber M (2011) "Motor Unit Number Index (MUNIX): A novel neurophysiological marker for neuromuscular disorders; test-retest reliability in healthy volunteers in a multicentre study". Clin Neurophysiol; 122, 1867-1872. (Journal IF: 2.786 Citations: 3).
      • Neuwirth C, Nandedkar S, Stalberg E, Barkhaus PE, de Carvalho M, Furtula J, van Dijk JP, Baldinger R, Castro J, Costa J, Otto M, Sandberg A, Weber M (2011) "Motor Unit Number Index (MUNIX): Reference values of five different muscles in healthy subjects from a multi-centre study". Clin Neurophysiol; 122, 1895-1896 (Journal IF: 2.786)
      • Almeida V, Ohana B, de Carvalho M, Swash M (in press) (2011) "Patrikios syndrome: two patients with treatable flail-leg weakness". J Clin Neurosci (Journal IF: 1.165).
      • de Carvalho M, Swash M (2011) "Amyotrophic Lateral Sclerosis: an update". Curr Opin Neurol; 24: 497-503. (Journal IF: 5.021 Citations: 1)
      • Pereira AF, Silva MT, Martins JM, de Carvalho M (2011) "Implementation of an efficient muscle fatigue model in the framework of multibody systems dynamics for analysis of human movements". J Multi-body Dynamics 225: 359-370 (Journal IF: 0.346)
      • Swash M, de Carvalho M, (2011) "Muscle ultrasound detects fasciculations and facilitates diagnosis in ALS". Neurology (Editorial) 77, 1508-1509 (Journal IF: 8.017)
      • Pugdahl K, Fuglsang-Frederiksen A, Tankisi H, Johnsen B, de Carvalho; Fawcett P, Labarre-Vila A, Liguori R, Nix W, Schofield I, (2011) "Impact of medical audit on electrodiagnostic medicine in polyneuropathy". Clin Neurophysiol 122, 2523-2529 (Journal IF: 2.786)
      • Peter P, Sharon A, Borasio GD, de Carvalho M, Chio A, Van Damme P, Hardiman O, Karen M, Petri S, Pradat P-F, Silani V, Barbara T, Wasner M, Markus W (in press) "EFNS guidelines on the clinical management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force". Eur J Neurol (Journal IF: 3.765)
      • de Carvalho M, Dengler R, Eisen A, England JD, Kaji R, Kimura R, Mills K, Mitsumoto H, Nodera H, Shefner J, Swash M (2011) "The Awaji criteria for diagnosis of ALS" (letter) Muscle Nerve 44, 456-7 (Journal IF: 2.320)
      • Neutel D, Miltenberger-Miltenyi G, Silva I, de Carvalho M (in press) (2011) Chorea-acanthocytosis presenting as motor neuron disease. Muscle Nerve (Journal IF: 2.320)
      • Pinto S, de Carvalho M, Swash M (in press) "Respiratory exercise in amyotrophic lateral sclerosis". Amyotr Lat Scler 13, 33-43 (Journal IF: 3.397)
      • Ostrowska M, de Carvalho M (in press) (2011) "Prognosis of phrenic nerve injury following thoracic interventions: 4 new cases and a review". Clin Neurol Neurosurg (Journal IF: 1.303)
      • Lopes de Almeida JP, Silvestre R, Pinto AC, de Carvalho M (in press) (2011) "Exercise and amyotrophic lateral sclerosis – a review". Neurol Sci (Journal IF: 1.220)
      • Pinto S, Pinto A, de Carvalho M (in press) (2011) "Decreased heart variability predicts death in amyotrophic lateral sclerosis". Muscle Nerve (Journal IF: 2.320)
      • Swash M (in press) (2011). "Survey of non-invasive ventilation use in ALS in Britain" (Editorial). J Neurol Neurosurg Psychiatry (JIF: 4.791).
      • Ratilal BO, Costa J, Sampaio C, Pappamikail L, (2011) "Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures". Cochrane Database Syst Review. 8: CD004884.
      • Saldanha C,de Almeida JP (2011) "Erythrocyte as a link between basic and clinical research."Clin Hemorheol Microcirc; 49:463-72. (JIF: 2.838).
      • Mariano, C.; Silva, S.; Pereira P.; Fernandes A.; Brites D.; Brito M. (2011). "Evidence of tricellulin expression by immune cells, particularly microglia". Biochem Biophys Res Commun; 409: 799-802. (JIF: 2.720).
      • de Carvalho M, Pinto S (2011) "Lithium treatment in amyotrophic lateral sclerosis: do we have enough?" Expert Rev Neurother; 11, 1693-1698.
      • Duarte ST, Oliveira J, Santos R, Pereira P, Barroso C, Conceição I, Evangelista T. (2011) "Dominant and recessive RYR1 mutations in adults with core lesions and mild muscle symptoms" Muscle Nerve 44; 102-108. (JIF: 2.320).
      • Ferreira M, Evangelista T, Almeida LS, Martins J, Macario MC, Martins E, Moleirinho A, Azevedo L, Vilarinho L, Santorelli FM (2011) " Relative frequency of known causes of multiple mtDNA deletions: two novel POLG mutations". Neuromuscul Disord 21: 483-8. (JIF: 2.764).
      • Pereira JP, Barroso C, Evangelista T, Fonseca JE, Pereira da Silva JA (2011) "Macrophagic myofasciitis: a case report of autoimmune/inflammatory syndrome induced by adjuvants (ASIA)". Acta Reumatol Port. 36: 75-6. (JIF: 0.726).
      • Ferreira DM, Castro RE, Machado MV, Evangelista T, Silvestre A, Costa A, Coutinho J, Carepa F, Cortez-Pinto H, Rodrigues CM (2011) "Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease". Diabetologia 54: 1788-98. (JIF: 6.973).
      • Swash M (2011) Nitric oxide and muscle weakness. (Editorial) Neurology 76: 940-941. (JIF: 8.017).
      • Valls-Sole J, Castillo CD, Casanova-Molla J, Costa J. (2011) Clinical consequences of reinnervation disorders after focal peripheral nerve lesions. Clin Neurophysiol.; 122: 219-28. (JIF: 2.786).
      • de Carvalho M and Swash M (2011) Fasciculation potentials: still mysterious Clin Neurophysiol (Editorial); 123: 399-401. (JIF: 2.786).
      • Costa J, Fareleira F, Ascenção R, Borges M, Sampaio C, Vaz-Carneiro A (2011) Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: A systematic review and meta-analysis. Epilepsia 52: 1280-91. (JIF: 3.955).
      • Bentes C, Costa J, Peralta R, Pires J, Sousa P, Paiva T (2011) Dream recall frequency and content in patients with temporal lobe epilepsy. Epilepsia; 52: 2022-7. (JIF: 3.955).
      • Costa J (2011) Is neurophysiology a valuable marker of pre-clinical stages of Lewy Body Disorders? Clin Neurophysiol 122: 2330-1. (JIF: 2.786).
      • Costa J, Guzmán J, Valldeoriola F, Rumià J, Tolosa E, Casanova-Molla J, Valls-Solé J (2011) Modulation of the soleus H reflex by electrical subcortical stimuli in humans. Exp Brain Res 112: 439-48. (JIF: 2.296).
      • de Almeida JP, Freitas-Santos T, Saldanha C, (2011) Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux - in vitro model of hyperfibrinogenemia".Clin Hemorheol Microcirc. 49: 407-16. (JIF: 2.838).
      • Oliveira M, Silva N, Matos L, Xavier R, Geraldes V, Ferreira R, Silva-Carvalho L, Rocha I (2011) "Effect of vagal stimulation on atrial refractoriness and vulnerability to induce atrial fibrillation in the anaesthetized rabbit". Exp Physiol. 96: 125-33. (JIF: 3.333).
      • Guimarães D, de M Carvalho; L, Geraldes V, Rocha I, Santos JP (2011) "Study of lead accumulation in bones of Wistar rats by X-ray fluorescence analysis: aging effect". Metallomics. 4: 66 – 71. (JIF: 3.359).
      • Oliveira M, da Silva N, Cunha P, Ramos R, Marques F, Santos S, Rocha I, Silva-Carvalho L, Ferreira R (2011) "Effects of acute autonomic modulation on atrial conduction delay and local electrograms duration in paroxysmal atrial fibrillation". Int Journal Cardiol 149: 290-295. (JIF: 6.802).
      • Guimarães D, JP Santos, ML Carvalho, G Vale, HM Santos, Geraldes, V, Rocha, I, JL Capelo (2011) "Ultrasonic energy as a tool to overcome some drawbacks in the determination of lead in brain tissue and urine of rats.". Talanta 86: 442–446. (JIF: 3.722).
      • Guimarães D, ML Carvalho , Geraldes, V, Rocha I, JP Santos (in press) "Lead concentration in feces and urine of exposed rats by X-ray Fluorescence and Electrothermal Atomic Absorption Spectrometry" XRay Spectroscopy (JIF: 1.661).
      • Delgado, E; Marques-Neves, C; Rocha, I ; Sales-Luís, J ; Silva-Carvalho, L (in press) "Modulation of Vasomotive Activity in Rabbit External Ophthalmic Artery by Neuropeptides". J Ophthalmology.
      • Domingos F, Escalda A (in press) "Causes of autonomic dysfunction in idiopathic recurrent kidney stone formers". Int Urol Nephrol. (JIF: 1.567).
      • Guimarães D, JP Santos, ML Carvalho, G Vale, HM Santos, Geraldes V, Rocha I, JL Capelo, Domingos F, Serra A (2011) "Nephrolithiasis is associated with an increased prevalence of cardiovascular disease" Nephrol Dial Transplant. 26: 864-8 (JIF: 3.564).
      • Fonseca AC, Geraldes R, Almeida V, Pinho e Melo T (2011) "Treatment with rtPA of stroke associated with intravenous immunoglobulins perfusion" J Neurol Sci. 308, 180-1.
      • Maia, TV, Frank M J (2011) From reinforcement learning models to psychiatric and neurological disorders. Nat Neuroscience 14: 154-162 (JIF: 14.191).
      • Horga G, Maia TV, Wang P, Wang Z, Marsh R, Peterson, BS (2011) Adaptation to conflict via context-driven anticipatory signals in the dorsomedial prefrontal cortex. J Neuroscience 31: 16208 –16216. (JIF: 7.270).
      • Posner J, Maia TV, Fair D, Peterson BS, Sonuga-Barke EJ, Nagel BJ (2011) The attenuation of dysfunctional emotional processing with stimulant medication: An fMRI study of adolescents with ADHD. Psychiatry Research: Neuroimaging 193:151-160. (JIF: 2.064).
      • Posner J, Nagel B J, Maia TV, Mechlin, A, Oh M, Wang Z, Peterson BS (2011) Abnormal amygdalar activation and connectivity in adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolescent Psychiatry 50: 828-837. (JIF: 5.148).
      • Wang Z, Maia TV, Marsh R, Colibazzi T, Gerber,A, Peterson, BS (in press) The neural circuits that generate tics in Gilles de la Tourette syndrome. American Journal of Psychiatry. (JIF: 12.759).
      • Maia TV, McClelland JL (in press). A neurocomputational approach to obsessive-compulsive disorder. Trends in Cognitive Sciences. (JIF: 9.686).
      • Swash M and de Carvalho M (2011). Muscle ultrasound detects fasciculations and facilitates diagnosis in ALS (Editorial). Neurology; 77: 1508-1509. Citações = 1 (JIF: 8.312).
      • Pugdahl K, Fuglsang-Frederiksen A, Tankisi H, Johnsen B, de Carvalho; Fawcett P, Labarre-Vila A, Liguori R, Nix W, Schofield I (2011). Impact of medical audit on electrodiagnostic medicine in polyneuropathy. Clin Neurophysiol; 122: 2523-2529 (JIF: 3.406).
      • de Carvalho M, Dengler R, Eisen A, England JD, Kaji R, Kimura R, Mills K, Mitsumoto H, Nodera H, Shefner J, Swash M (2011). The Awaji criteria for diagnosis of ALS (letter). Muscle Nerve; 44: 456-7 (JIF: 2.367).
      • Rodrigues SM, de Carvalho M, Mestre T, Ferreira JJ, Coelho M, Peralta R, Vale P (2012). Paralytic shellfish poisoning due to ingestion of Gymnodinium catenatum contamined cockles – application of the AOAC HPLC official method. Toxicon 59: 558-566 (JIF: 2.451).
      • Vasconcelos A, Abecasis F, Monteiro R, Camilo C, Vieira M, de Carvalho M, Correia M (2012). A 3-month-old baby with H1N1 and Guillain-Barre syndrome. BMJ Case Rep pii: bcr1220115462. doi: 10.1136/bcr.12.2011.5462.
      • Conceição I, NZwalo H, de Carvalho M (in press). Coexistence of transthyretin familial amyloid polyneuropathy and hereditary neuropathy with liability to pressure palsy. Clin Neurol Neurosurg (JIF: 1.303).
      • de Carvalho M (in press). Estimating the value of estimation. Clin Neurophysiol (editorial) (JIF: 3.406).
      • Costa J, Swash M, de Carvalho M (in press). The Awaji criteria for the diagnosis of ALS: a systematic review. Arch Neurol (JIF: 7.584).
      • Pinto S, Pinto A, de Carvalho M (in press). Phrenic nerve studies predict survival in Amyotrophic Lateral Sclerosis. Clin Neurophysiol (JIF: 3.406).
      • de Carvalho M (2012). Does Awaji decrease diagnostic yield in ALS? (letter). Muscle Nerve 46:142-143 (JIF: 2.367).
      • Chester C, de Carvalho M, Miltenberger G, Pereira S, Dillen L, van der Zee J, Broeckhoven CV, de Mendonça A (in press). Rapidly progressive fronto temporal dementia and bulbar amyotrophic lateral sclerosis in Portuguese patients with C9orf72 mutation. Amyotr Lat Scler (JIF: 3.397).
      • Pena MJ, Ravasco P, Machado M, Pinto A, Pinto S, Rocha L, de Carvalho M, Cortez Pinto H (2012). What is the relevance of percutaneous endoscopic gastrostomy on the survival of patients with amyotrophic lateral sclerosis? Amyotr Lat Scler 13:550-554 (JIF: 3.397).
      • Mestre TA, Lang AE, Ferreira JJ, Almeida V, de Carvalho M, Miyasaki J, Chen R, Fox SH (2012). Associated movement disorders in orthostatic tremor. J Neurol Neurosurg Psychiatry 83:725-729 (JIF: 4.764).
      • Almeida V, de Carvalho M, Scotto M, Pinto P, Pinto A, Ohana B, Swash M (in press). Primary lateral sclerosis: predicting functional outcome. Amyotr Lat Scler (JIF: 3.397).
      • Lopes de Almeida JP, Pinto A, Pinto S, Ohana B, de Carvalho M (2012). Economic Cost of Home-Telemonitoring Care for BiPAP-assisted ALS Individuals. Amyotr Lat Scler 13:533-537 (JIF: 3.397).
      • de Carvalho M (in press). Testing upper motor neuron function in amyotrophic lateral sclerosis: the most difficult task of neurophysiology. Brain (JIF: 9.457).
      • Pinto S, de Carvalho M (in press). Can inspiratory muscle training increase survival in early-affected Amyotrophic Lateral Sclerosis patients? Amyotr Lat Scler (JIF: 3.397).
      • de Carvalho M (in press). Split-had to diagnosis shot. Clin Neurophysiol (editorial) (JIF: 3.406).
      • de Carvalho M. (in press). Is better than it seems or just good enough? The Tafamidis saga". Muscle Nerve (editorial) (JIF: 2.367).
      • Conceição I. Clinical Features of TTR- FAP in Portugal.. Amyloid. 2012 Jun;19 Suppl 1:71-2. Epub 2012 Apr 6.
      • Coelho T, Maia LF, Martins da Silva A, Waddington Cruz M, Planté-Bordeneuve V, Lozeron P, Suhr O, Campistol J M, Conceição I, Schmidt H. J., Trigo P, Kelly J, Labaudinière R, Chan J, Packman J, Wilson A, And Grogan D R. Tafamidis For transthyretin familial amyloid polyneuropathy: a randomized, controlled trial. Neurology. 2012 Aug 21;79(8):785-92.
      • Dombrowski, P. A., Maia, T. V., Boschen, S. L., Bortolanza, M., Wendler, E., Schwarting, R. K. W., Brandão, M. L., Winn, P., Blaha, C. D., & Da Cunha, C. (in press). Evidence that conditioned avoidance responses are reinforced by positive prediction errors signaled by striatal dopamine. Behavioural Brain Research.
      • Horga*, G. & Maia*, T. V. (2012). Conscious and unconscious processes in cognitive control: a theoretical perspective and a novel empirical approach. Frontiers in Human Neuroscience, Vol. 6:199, pp. 1-7. *Authors contributed equally.
      • Horga, G., Maia, T. V., Wang, P., Wang, Z., Marsh, R., & Peterson, B. S. (2011). Adaptation to conflict via context-driven anticipatory signals in the dorsomedial prefrontal cortex. Journal of Neuroscience, Vol. 31, No. 45, pp. 16208 –16216.
      • Posner, J., Nagel, B. J., Maia, T. V., Mechling, A., Oh, M., Wang, Z., & Peterson, B. S. (2011). Abnormal amygdalar activation and connectivity in adolescents with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 50, No. 8, pp. 828-837.
      • Maia, T. V., & Frank, M. J. (2011). From reinforcement learning models to psychiatric and neurological disorders. Nature Neuroscience, Vol. 14, No. 2, pp. 154-162.
      • Postolache O, Girão SPM, Postolache G. Seismocardiogram and Ballistocardiogram Sensing. International Journal of Measurement Technologies and Instrumentations Engineering (IJMTIE), vol. 1, no.3, pp.367-388, 2011
      • Postolache O, Girão SPM, Perreira DM, Postolache G. FMCW Radar Sensors for Vital Signs and Motor Activity Monitoring. ICST Transaction on Ambient System, vol. 11, no. 10-12, pp. 1-10, 2011

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