====== Psichomics ======

**Graphical application for alternative splicing quantification and analysis** \\
//by// Nuno Agostinho [[nunoagostinho@medicina.ulisboa.pt|nunoagostinho@medicina.ulisboa.pt]]\\

**Interactive R package** with an intuitive **Shiny-based graphical interface** for alternative splicing quantification and integrative analyses of alternative splicing and gene expression based on The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression (GTEx) project, Sequence Read Archive (SRA), and user-provided data.

//psichomics// interactively perform survival, dimensionality reduction and median- and variance-based differential splicing and gene expression analyses that benefit from the incorporation of clinical and molecular sample-associated features (such as tumour stage or survival). Interactive visual access to genomic mapping and functional annotation of selected alternative splicing events is also included.

**Tutorial:** [[https://link.springer.com/protocol/10.1007%2F978-1-0716-0301-7_10|Interactive Alternative Splicing Analysis of Human Stem Cells Using psichomics]]

**Saraiva-Agostinho N**, Barbosa-Morais NL (2019). “psichomics: graphical application for alternative splicing quantification and analysis.” Nucleic Acids Research, 47(2), e7. [[https://doi.org/10.1093/nar/gky888|DOI: 10.1093/nar/gky888]].

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