Bio
Hi, my name is Marie and I am currently
doing my PhD at Nuno Morais' Lab! I have a
life-long / permanent / ever-growing interest
in the best organ in the human body - the
brain - and specifically in neurodegenerative diseases such as Parkinson’s disease. In fact, I did my Master's thesis in Parkinson’s disease, in a wet lab context.
Nuno Morais's Lab allowed me to continue studying the diseased human
brain through a different prism that is using
bioinformatics. In summary, my PhD project
consists of assessing transcriptomic
variations and alterations in the expression
of splicing factors in idiopathic Parkinson’s
brains, based on bioinformatics analyses of
already existing data. Once those alterations are identified, we will validate them in an independent set of clinical brain samples of idiopathic Parkinson’s brains and functionally explore their consequences in vitro.
Publications
Leznicki P, Natarajan J, Bader G,
Spevak W, Schlattl A, Rehman SAA, Pathak D,
Weidlich S, Zoephel A, Bordone MC,
Barbosa-Morais NL, Boehmelt G, Kulathu
Y. "Expansion of DUB functionality by
alternative isoforms: USP35, a case
study.". J Cell Sci. 2018 Apr 23. pii:
jcs.212753. doi: 10.1242/jcs.212753.
[PUBMED]
Gallego-Paez LM, Bordone MC, Leote AC, Saraiva-Agostinho N, Ascensao-Ferreira M, Barbosa-Morais NL. "Alternative
splicing: the pledge, the turn, and the
prestige - The key role of alternative
splicing in human biological systems."
Hum Genet., 2017
Sep;136(9):1015-1042. [PUBMED]