I am Biologist with emphasis on Genetics
del Valle in Cali, Colombia. I carried out
my Master's and PhD studies at the Laboratory
of Genome Structure and Function at the Tokyo
Institute of Technology, working during
this period as Research Assistant at the University
of Tokyo and later on at the Japanese Foundation for Cancer Research (Laboratory of Experimental Pathology).
For my postdoctoral research, I decided to jump from the chromatin structure field into the world of alternative splicing and transcriptional regulation by joining the NMorais Lab in 2015. Since then, I've been focused on the characterisation of alterations in the alternative splicing program in colorectal cancer and how these perturbations contribute to disease progression and prognosis, using publicly available molecular and clinical data from The Cancer Genome Atlas (TCGA) project.
Gallego-Paez LM, Bordone MC, Leote AC, Saraiva-Agostinho N, Ascensao-Ferreira M, Barbosa-Morais NL. "Alternative splicing: the pledge, the turn, and the prestige - The key role of alternative splicing in human biological systems." Hum Genet., 2017 Apr 3. doi: 10.1007/s00439-017-1790-y. [PUBMED]
Sridhara SC, Carvalho S, Grosso AR, Gallego-Paez LM, Carmo-Fonseca M, de Almeida SF. "Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation." Cell Rep., 2017 Jan 10;18(2):334-343. [PUBMED]
Gallego-Paez LM, Tanaka H, Bando M, Takahashi M, Nozaki N, Nakato R, Shirahige K, Hirota T. "Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells." Mol Biol Cell., 2014 Jan;25(2):302-17. [PUBMED]