Bio

I am a computational biologist interested in understanding the molecular mechanisms behind tumour development. Biological questions are my main passion and computational approaches my way of life!

Currently, I am working on the mechanisms of centrosome amplification and their therapeutic value in cancer, in collaboration with Mónica Bettencourt-Dias’ Lab at Instituto Gulbenkian de Ciência and Gonçalo Bernardes at iMM. Using computational methods, I am integrating data from a screen for centrosome number, done in Mónica’s lab on the NCI-60 panel of human cancer cell lines, with publicly available molecular (genomic, transcriptomic and proteomic) and drug-sensitivity data for that panel, to identify novel diagnostic, prognostic and therapeutic directions in cancer. I am also interested in the role of the non-coding genome in cancer and in the impact of cancer-associated DNA variants on oncogenic splicing dysregulation.

I got my undergraduate degree in Biomedical Sciences at the University of Algarve, in 2015. After graduating, I started a Master’s degree in Oncobiology at the same University and did my Master’s thesis project with Nuno Morais, at iMM. Before joining iMM, I have spent a month with Daniel Gaffney’s group, at the Sanger Institute, working on a map of histone Quantitative Trait Loci in human induced Pluripotent Stem Cells, with data from the HipSci project. Earlier still, I trained with Ana Teresa Maia at the Centre for Biomedical Research (CBMR) in Algarve, where I worked on the identification of new genetic risk markers and on cis-regulation of somatic mutations, both in breast cancer.

My Master's thesis in one minute:

Publications

Marteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA, Bettencourt-Dias M. "Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation". Nat Commun, 2018 Mar 28;9(1):1258. [PUBMED]
. "Finding the Achilles heel of cancer"
. "Cancers of Many Kinds Give Centriole Amplification Starring Role"
. "Identificadas características das células cancerosas que podem ser o seu calcanhar de Aquiles"
. "Identificadas características das células cancerígenas que podem ajudar médicos"
. "Equipa liderada por portuguesa dá mais um passo no combate ao cancro"
. "Cientistas portugueses descobrem “calcanhar de Aquiles“ das células cancerígenas"
. "Portuguesa lidera equipa que descobriu novos traços das células do cancro"

Abstracts

de Almeida BP, , Marteil G, Bettencourt-Dias M, Barbosa-Morais NL. "Discovery of novel mechanisms of centrosome amplification and their therapeutic value in cancer." Porto Biomedical Journal, 2017 Sep-Oct; 2(5):182. doi: 10.1016/j.pbj.2017.07.019