I am a computational biologist interested in understanding the molecular mechanisms behind tumour development. Biological questions are my main passion and computational approaches my way of life!
Currently, I am working on the mechanisms of centrosome amplification and their therapeutic value in cancer, in collaboration with Mónica Bettencourt-Dias’ Lab at Instituto Gulbenkian de Ciência and Gonçalo Bernardes at iMM. Using computational methods, I am integrating data from a screen for centrosome number, done in Mónica’s lab on the NCI-60 panel of human cancer cell lines, with publicly available molecular (genomic, transcriptomic and proteomic) and drug-sensitivity data for that panel, to identify novel diagnostic, prognostic and therapeutic directions in cancer. I am also interested in the role of the non-coding genome in cancer and in the impact of cancer-associated DNA variants on oncogenic splicing dysregulation.
I got my undergraduate degree in Biomedical Sciences at the University of Algarve, in 2015. After graduating, I started a Master’s degree in Oncobiology at the same University and did my Master’s thesis project with Nuno Morais, at iMM. Before joining iMM, I have spent a month with Daniel Gaffney’s group, at the Sanger Institute, working on a map of histone Quantitative Trait Loci in human induced Pluripotent Stem Cells, with data from the HipSci project. Earlier still, I trained with Ana Teresa Maia at the Centre for Biomedical Research (CBMR) in Algarve, where I worked on the identification of new genetic risk markers and on cis-regulation of somatic mutations, both in breast cancer.
My Master's thesis in one minute:
Marteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA, Bettencourt-Dias M. "Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation". Nat Commun, 2018 Mar 28;9(1):1258. [PUBMED]
. "Finding the Achilles heel of cancer"
. "Cancers of Many Kinds Give Centriole Amplification Starring Role"
. "Identificadas características das células cancerosas que podem ser o seu calcanhar de Aquiles"
. "Identificadas características das células cancerígenas que podem ajudar médicos"
. "Equipa liderada por portuguesa dá mais um passo no combate ao cancro"
. "Cientistas portugueses descobrem “calcanhar de Aquiles“ das células cancerígenas"
. "Portuguesa lidera equipa que descobriu novos traços das células do cancro"
de Almeida BP, , Marteil G, Bettencourt-Dias M, Barbosa-Morais NL. "Discovery of novel mechanisms of centrosome amplification and their therapeutic value in cancer." Porto Biomedical Journal, 2017 Sep-Oct; 2(5):182. doi: 10.1016/j.pbj.2017.07.019